1
40
32
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Text
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URL Address
<a href="http://doi.org/10.1007/s00431-004-1541-7" target="_blank" rel="noreferrer">http://doi.org/10.1007/s00431-004-1541-7</a>
Dublin Core
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Title
A name given to the resource
Effective parenteral clodronate treatment of a child with severe juvenile idiopathic osteoporosis
Publisher
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European Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Child; Humans; Male; Age Factors; Infusions; Clodronate; Recurrence; Antimetabolites/administration & dosage/therapeutic use; Bone Density/drug effects; Clodronic Acid/administration & dosage/therapeutic use; Osteoporosis/drug therapy; Parenteral; Puberty
Creator
An entity primarily responsible for making the resource
Melchior R; Zabel B; Spranger J; Schumacher R
Description
An account of the resource
We report on an 8 years and 3 months old boy with severe idiopathic juvenile osteoporosis (IJO). Clinical features included multiple fractures, especially of the vertebrae, and neurological symptoms. Biological studies showed non-parathyroid hormone-mediated excessive bone resorption and massive urinary calcium loss. Although IJO is usually a self-limiting condition after puberty, the severity of our patient's manifestations required therapeutic intervention. Clodronate (dichloromethylene-bisphosphonate) was administered parenterally every 3 months for a period of 2 years. Dramatic clinical and biochemical improvement was noted within 2 weeks. All parameters of bone resorption normalised and no new fractures occurred. After 6 months of treatment, radiological improvement with healing of fractures and rebuilding of the vertebral plates was documented. Bone mineral density increased to normal within 1 year and growth velocity was accelerated. After 2 years, treatment was stopped at the age of 10 years and 3 months. One year later, back pain and increasing pain in the knee region recurred. A tibial fracture was evident and, again, bone mineral density was far below normal. Bisphosphonate medication was reinstituted leading to rapid improvement. No side-effects were observed. CONCLUSION: Parenteral clodronate therapy is effective in managing severe idiopathic juvenile osteoporosis.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00431-004-1541-7" target="_blank" rel="noreferrer">10.1007/s00431-004-1541-7</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Age Factors
Antimetabolites/administration & dosage/therapeutic use
Backlog
Bone Density/drug effects
Child
Clodronate
Clodronic Acid/administration & dosage/therapeutic use
European Journal of Pediatrics
Humans
Infusions
Journal Article
Male
Melchior R
Osteoporosis/drug therapy
Parenteral
Puberty
Recurrence
Schumacher R
Spranger J
Zabel B
-
Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/s00431-005-1698-8" target="_blank" rel="noreferrer">http://doi.org/10.1007/s00431-005-1698-8</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A literature review on off-label drug use in children
Publisher
An entity responsible for making the resource available
European Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Child; Humans; infant; Adult; Age Factors; Hospitals; Prescriptions; adolescent; Preschool; infant; Newborn; Clodronate; Community Health Services/statistics & numerical data; Drug Labeling/statistics & numerical data; Drug/statistics & numerical data; Legislation; Pediatric/statistics & numerical data
Creator
An entity primarily responsible for making the resource
Pandolfini C; Bonati M
Description
An account of the resource
The aim was to compare results of studies performed in different settings worldwide and identify common therapeutic areas to allow for focused interventions, because off-label drug use can be a measure of the lack of knowledge concerning paediatric treatments. A secondary objective was to provide a brief review of efforts to date. A literature review of articles on off-label and unlicensed drug use in children involving general prescription samples was performed using Medline and Embase. In all, 30 studies from 1985-2004 were included. Eleven involved paediatric hospital wards, seven neonatal hospital wards, and 12 the community setting. The off-label and unlicensed classification methods varied, making results difficult to compare. In general, off-label/unlicensed prescription rates ranged from 11%-80%, and higher rates were found in younger versus older patients and in the hospital versus community settings. On the paediatric hospital wards, off-label/unlicensed prescriptions ranged from 16%-62% and most often concerned acetaminophen, cisapride, chloral hydrate, and salbutamol. In the neonatal wards, rates ranged from 55%-80% and often involved caffeine. In the community setting, rates ranged from 11%-37% and the most commonly implicated drugs were salbutamol and amoxicillin. Conclusion:A lack of harmonization between the evidence, the information available to doctors, and its use in clinical practice exists and this is part of the reason off-label therapies are so common. Attempts have been made to improve knowledge concerning paediatric treatments, but more focused interventions are needed, also taking into consideration this lack of harmonization.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00431-005-1698-8" target="_blank" rel="noreferrer">10.1007/s00431-005-1698-8</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Adolescent
Adult
Age Factors
Backlog
Bonati M
Child
Clodronate
Community Health Services/statistics & numerical data
Drug Labeling/statistics & numerical data
Drug/statistics & numerical data
European Journal of Pediatrics
Hospitals
Humans
Infant
Journal Article
Legislation
Newborn
Pandolfini C
Pediatric/statistics & Numerical Data
Preschool
Prescriptions
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1080/08880010500198285" target="_blank" rel="noreferrer">http://doi.org/10.1080/08880010500198285</a>
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Title
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Osteoporosis at presentation of childhood ALL: management with pamidronate
Publisher
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Pediatric Hematology And Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Child; Female; Humans; Male; Leukemia; Preschool; Clodronate; Acute; Lymphocytic; Bone Density/drug effects; Diphosphonates/administration & dosage; Fractures; Bone Density Conservation Agents/administration & dosage; L1/complications/radiography/therapy; Osteoporosis/drug therapy/etiology/radiography; Spinal Fractures/drug therapy/etiology/radiography; Spontaneous/drug therapy/etiology/radiography
Creator
An entity primarily responsible for making the resource
Goldbloom EB; Cummings EA; Yhap M
Description
An account of the resource
Vertebral fractures at diagnosis of childhood acute lymphoblastic leukemia (ALL) are an uncommon but recognized problem. Clinical issues associated with pathological fractures in these children include pain control and the potential for further treatment-associated fractures and long-term bony morbidity. The authors report the successful use of pamidronate in two children who presented with vertebral compression fractures at diagnosis of ALL. Both patients had pain and low bone mineral density at baseline. In addition to standard chemotherapy, pamidronate (1 mg/kg, IV) was given bimonthly. Initial rapid symptom relief and gradual improvement of bone mineral density was demonstrated in both patients.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/08880010500198285" target="_blank" rel="noreferrer">10.1080/08880010500198285</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Acute
Backlog
Bone Density Conservation Agents/administration & dosage
Bone Density/drug effects
Child
Clodronate
Cummings EA
Diphosphonates/administration & dosage
Female
Fractures
Goldbloom EB
Humans
Journal Article
L1/complications/radiography/therapy
Leukemia
Lymphocytic
Male
Osteoporosis/drug therapy/etiology/radiography
Pediatric Hematology And Oncology
Preschool
Spinal Fractures/drug therapy/etiology/radiography
Spontaneous/drug therapy/etiology/radiography
Yhap M
-
Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1186/1471-2431-5-38" target="_blank" rel="noreferrer">http://doi.org/10.1186/1471-2431-5-38</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Children in reviews: methodological issues in child-relevant evidence syntheses
Publisher
An entity responsible for making the resource available
Bmc Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
PedPal Lit; Clodronate
Creator
An entity primarily responsible for making the resource
Cramer K; Wiebe N; Moyer V; Hartling L; Williams K; Swingler G; Klassen TP
Description
An account of the resource
BACKGROUND: The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews (CDSR); and ii) determine when effect sizes for the same drug interventions differ between children and adults. METHODS: We systematically identified all of the reviews relevant to child health in the CDSR 2002, Issue 4. Reviews were included if they investigated the efficacy or effectiveness of a drug intervention for a condition that occurs in both children and adults. Information was extracted on review characteristics including study methods, results, and conclusions. RESULTS: From 1496 systematic reviews, 408 (27%) were identified as relevant to both adult and child health; 52% (213) of these included data from children. No significant differences were found in effect sizes between adults and children for a ny of the drug interventions or conditions investigated. However, all of the comparisons lacked the power to detect a clinically significant difference and wide confidence intervals suggest important differences cannot be excluded. A large amount of data was unavailable due to inadequate reporting at the trial and systematic review level. CONCLUSION: Overall, the findings of this study indicate there is a paucity of child-relevant and specific evidence generated from evidence syntheses of drug interventions. The results indicate a need for a higher standard of reporting for participant populations in studies of drug interventions.;
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/1471-2431-5-38" target="_blank" rel="noreferrer">10.1186/1471-2431-5-38</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Backlog
Bmc Pediatrics
Clodronate
Cramer K
Hartling L
Journal Article
Klassen TP
Moyer V
PedPal Lit
Swingler G
Wiebe N
Williams K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/14651858.cd002068" target="_blank" rel="noreferrer">http://doi.org/10.1002/14651858.cd002068</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Bisphosphonates for the relief of pain secondary to bone metastases
Publisher
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Cochrane Database Of Systematic Reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Analgesics; Pain/drug therapy; Non-Narcotic/therapeutic use; Antineoplastic Agents/therapeutic use; Bone Neoplasms/complications/drug therapy/secondary; Clodronate; Clodronic Acid/therapeutic use; Diphosphonates/therapeutic use; Etidronic Acid/therapeutic use; Randomized Controlled Trials
Creator
An entity primarily responsible for making the resource
Wong R; Wiffen PJ
Description
An account of the resource
BACKGROUND: Bisphosphonates form part of standard therapy for hypercalcemia and the prevention of skeletal events in some cancers. However, the role of bisphosphonates in pain relief for bony metastases remains uncertain. OBJECTIVES: To determine the effectiveness of bisphosphonates for the relief of pain from bone metastases. SEARCH STRATEGY: MEDLINE (1966-1999), EMBASE (1980-1999), CancerLit (1966-1999), the Cochrane library (Issue 1, 2000) and the Oxford Pain Database were searched using the strategy devised by the Cochrane Pain, Palliative and Supportive Care Group with additional terms 'diphosphonate', 'bisphosphonate', 'multiple myeloma' and 'bone neoplasms'. (Last search: January 2000). SELECTION CRITERIA: Randomized trials of bisphosphonates compared with open, blinded, or different doses/types of bisphosphonates in cancer patients were included where pain and/or analgesic consumption were outcome measures. Studies where pain was reported only by observers were excluded. DATA COLLECTION AND ANALYSIS: Article eligibility, quality assessment and data extraction were undertaken by both reviewers. The proportions of patients with pain relief at 4, 8 and 12 weeks were assessed. The proportion of patients with analgesic reduction, the mean pain score, mean analgesic consumption, adverse drug reactions, and quality of life data were compared as secondary outcomes. MAIN RESULTS: Thirty randomized controlled studies (21 blinded, four open and five active control) with a total of 3682 subjects were included. For each outcome, there were few studies with available data. For the proportion of patients with pain relief (eight studies) pooled data showed benefits for the treatment group, with an NNT at 4 weeks of 11[95% CI 6-36] and at 12 weeks of 7 [95% CI 5-12]. In terms of adverse drug reactions, the NNH was 16 [95% CI 12-27] for discontinuation of therapy. Nausea and vomiting were reported in 24 studies with a non-significant trend for greater risk in the treatment group. One study showed a small improvement in quality of life for the treatment group at 4 weeks. The small number of studies in each subgroup with relevant data limited our ability to explore the most effective bisphosphonates and their relative effectiveness for different primary neoplasms. REVIEWER'S CONCLUSIONS: There is evidence to support the effectiveness of bisphosphonates in providing some pain relief for bone metastases. There is insufficient evidence to recommend bisphosphonates for immediate effect; as first line therapy; to define the most effective bisphosphonates or their relative effectiveness for different primary neoplasms. Bisphosphonates should be considered where analgesics and/or radiotherapy are inadequate for the management of painful bone metastases.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/14651858.cd002068" target="_blank" rel="noreferrer">10.1002/14651858.cd002068</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Analgesics
Antineoplastic Agents/therapeutic use
Backlog
Bone Neoplasms/complications/drug therapy/secondary
Clodronate
Clodronic Acid/therapeutic use
Cochrane Database of Systematic Reviews
Diphosphonates/therapeutic use
Etidronic Acid/therapeutic use
Humans
Journal Article
Non-Narcotic/therapeutic use
Pain/drug Therapy
Randomized Controlled Trials
Wiffen PJ
Wong R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/mpo.10057" target="_blank" rel="noreferrer">http://doi.org/10.1002/mpo.10057</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Osteopenia in children with acute lymphoblastic leukemia: a pilot study of amelioration with Pamidronate
Publisher
An entity responsible for making the resource available
Medical & Pediatric Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Pilot Projects; Leukemia; Drug Administration Schedule; Bone Diseases; adolescent; Preschool; P.H.S.; Research Support; U.S. Gov't; Clodronate; Acute; Anti-Inflammatory Agents/administration & dosage/therapeutic use; Antineoplastic Agents/administration & dosage/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Asparaginase/therapeutic use; Dexamethasone/therapeutic use; Diphosphonates/administration & dosage/therapeutic use; Doxorubicin/therapeutic use; L1/complications/drug therapy; Lymphocytic; Metabolic/drug therapy/etiology
Creator
An entity primarily responsible for making the resource
Barr RD; Guo CY; Wiernikowski J; Webber C; Wright M; Atkinson S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/mpo.10057" target="_blank" rel="noreferrer">10.1002/mpo.10057</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Acute
Adolescent
Anti-Inflammatory Agents/administration & dosage/therapeutic use
Antineoplastic Agents/administration & dosage/therapeutic use
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Asparaginase/therapeutic use
Atkinson S
Backlog
Barr RD
Bone Diseases
Child
Clodronate
Dexamethasone/therapeutic use
Diphosphonates/administration & dosage/therapeutic use
Doxorubicin/therapeutic use
Drug Administration Schedule
Female
Guo CY
Humans
Journal Article
L1/complications/drug therapy
Leukemia
Lymphocytic
Male
Medical & Pediatric Oncology
Metabolic/drug therapy/etiology
P.H.S.
Pilot Projects
Preschool
Research Support
U.S. Gov't
Webber C
Wiernikowski J
Wright M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/s11926-003-0085-6" target="_blank" rel="noreferrer">http://doi.org/10.1007/s11926-003-0085-6</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonate mechanism of action
Publisher
An entity responsible for making the resource available
Current Rheumatology Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Clodronate; Apoptosis; Bone Resorption/metabolism; Diphosphonates/chemistry/metabolism/pharmacology; Mevalonic Acid/antagonists & inhibitors; Osteoclasts/drug effects/metabolism/physiology; Osteoporosis/metabolism
Creator
An entity primarily responsible for making the resource
Reszka AA; Rodan GA
Description
An account of the resource
The nitrogen-containing bisphosphonates (N-BPs), alendronate and risedronate, are the only pharmacologic agents shown to prevent spine and nonvertebral fractures associated with postmenopausal and glucocorticoid-induced osteoporosis. At the tissue level, this is achieved through osteoclast inhibition, which leads to reduced bone turnover, increased bone mass, and improved mineralization. The molecular targets of bisphosphonates (BPs) have recently been identified. This review will discuss the mechanism of action of BPs, focusing on alendronate and risedronate, which are the two agents most widely studied. They act on the cholesterol biosynthesis pathway enzyme, farnesyl diphosphate synthase. By inhibiting this enzyme in the osteoclast, they interfere with geranylgeranylation (attachment of the lipid to regulatory proteins), which causes osteoclast inactivation. This mechanism is responsible for N-BP suppression of osteoclastic bone resorption and reduction of bone turnover, which leads to fracture prevention.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11926-003-0085-6" target="_blank" rel="noreferrer">10.1007/s11926-003-0085-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Apoptosis
Backlog
Bone Resorption/metabolism
Clodronate
Current Rheumatology Reports
Diphosphonates/chemistry/metabolism/pharmacology
Humans
Journal Article
Mevalonic Acid/antagonists & inhibitors
Osteoclasts/drug effects/metabolism/physiology
Osteoporosis/metabolism
Reszka AA
Rodan GA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.jpeds.2004.06.066" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jpeds.2004.06.066</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Short-term safety assessment in the use of intravenous zoledronic acid in children
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Humans; Male; Follow-Up Studies; Time Factors; adolescent; Preschool; retrospective studies; Infusions; Intravenous; Fever/chemically induced; Nausea/chemically induced; Clodronate; Calcium/blood; Bone Resorption/metabolism/prevention & control; Creatinine/blood; Diphosphonates/administration & dosage/adverse effects; Imidazoles/administration & dosage/adverse effects; Pain/chemically induced; Phosphorus/blood; Urea/blood; Vomiting/chemically induced
Creator
An entity primarily responsible for making the resource
Hogler W; Yap F; Little D; Ambler G; McQuade M; Cowell CT
Description
An account of the resource
The clinical side effects of the potent new bisphosphonate zoledronic acid in children are unknown. In this study of 34 children with various bone disorders, the frequency of postinfusion flu-like illness, hypocalcemia, and hypophosphatemia was 85%, 74%, and 82%, respectively. No renal side effects were detected after up to 3 consecutive infusions.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jpeds.2004.06.066" target="_blank" rel="noreferrer">10.1016/j.jpeds.2004.06.066</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adolescent
Ambler G
Backlog
Bone Resorption/metabolism/prevention & control
Calcium/blood
Child
Clodronate
Cowell CT
Creatinine/blood
Diphosphonates/administration & dosage/adverse effects
Female
Fever/chemically induced
Follow-up Studies
Hogler W
Humans
Imidazoles/administration & dosage/adverse effects
Infusions
Intravenous
Journal Article
Little D
Male
McQuade M
Nausea/chemically induced
Pain/chemically induced
Phosphorus/blood
Preschool
Retrospective Studies
The Journal Of Pediatrics
Time Factors
Urea/blood
Vomiting/chemically induced
Yap F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(03)00225-2" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(03)00225-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The use of subcutaneous pamidronate
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Injections; Subcutaneous; Clodronate; Hypercalcemia/drug therapy; Anti-Inflammatory Agents/administration & dosage; Diphosphonates/administration & dosage
Creator
An entity primarily responsible for making the resource
Duncan AR
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(03)00225-2" target="_blank" rel="noreferrer">10.1016/s0885-3924(03)00225-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2003
2003
Anti-Inflammatory Agents/administration & dosage
Backlog
Clodronate
Diphosphonates/administration & dosage
Duncan AR
Humans
Hypercalcemia/drug therapy
Injections
Journal Article
Journal of Pain and Symptom Management
Subcutaneous
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(03)00252-5" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(03)00252-5</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Safety of subcutaneous clodronate and efficacy in hypercalcemia of malignancy: a novel route of administration
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; Male; Cohort Studies; Analgesics; Treatment Outcome; Non-U.S. Gov't; Research Support; retrospective studies; Injections; Neoplasms/complications; Subcutaneous; Clodronate; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage; Hypercalcemia/drug therapy/etiology
Creator
An entity primarily responsible for making the resource
Roemer-Becuwe C; Vigano A; Romano F; Neumann C; Hanson J; Quan HK; Walker P
Description
An account of the resource
Bisphosphonates have become standard treatment in management of malignancy-induced hypercalcemia and malignant bone pain. One obstacle to the routine use of bisphosphonates in palliative patients is that oral bisphosphonates have low bioavailability and a degree of gastrointestinal toxicity that may explain poor compliance. Intravenous administration can be cumbersome in patients admitted to long-term care settings or at home. We have developed and tested a new way of administering clodronate via subcutaneous infusion. This retrospective cohort study evaluated 150 patients admitted to a tertiary palliative care unit from May 1996 to May 2000 who received 254 subcutaneous infusions of clodronate for hypercalcemia or bony complications. Data were collected by chart review and specifically evaluated site toxicity and biochemistry. There was minimal local toxicity and only 2 infusions needed to be discontinued because of pain at the subcutaneous site. Clodronate showed efficacy in normalizing the serum calcium within 5 days post-infusion in 32 of 43 infusions given for hypercalcemia. This study shows that subcutaneous clodronate is safe and can lower serum calcium levels in malignant hypercalcemia.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(03)00252-5" target="_blank" rel="noreferrer">10.1016/s0885-3924(03)00252-5</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Analgesics
Backlog
Clodronate
Clodronic Acid/administration & dosage
Cohort Studies
Female
Hanson J
Humans
Hypercalcemia/drug therapy/etiology
Injections
Journal Article
Journal of Pain and Symptom Management
Male
Neoplasms/complications
Neumann C
Non-Narcotic/administration & dosage
Non-U.S. Gov't
Quan HK
Research Support
Retrospective Studies
Roemer-Becuwe C
Romano F
Subcutaneous
Treatment Outcome
Vigano A
Walker P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s1471-4892(02)00218-7" target="_blank" rel="noreferrer">http://doi.org/10.1016/s1471-4892(02)00218-7</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
New uses of bisphosphonates: osteogenesis imperfecta
Publisher
An entity responsible for making the resource available
Current Opinion in Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Clodronate; Bone Density/drug effects; Diphosphonates/pharmacology/therapeutic use; Osteogenesis Imperfecta/classification/diagnosis/drug therapy
Creator
An entity primarily responsible for making the resource
Devogelaer JP
Description
An account of the resource
Osteogenesis imperfecta is a heterogeneous group of inherited disorders chiefly affecting type I collagen, resulting in bone fragility responsible for a host of recurrent fractures. Limb and spine deformities, growth failure and restricted mobility are the end-result in severe cases. Cyclical intermittent intravenous infusions of pamidronate, a potent inhibitor of bone resorption, have yielded substantial improvement in chronic pain, bone mineral density, fracture rate and mobility without significant side effects. The role of growth hormone and bone marrow transplantation in the treatment of osteogenesis imperfecta is still unresolved. Newer, theoretically more potent bisphosphonates are currently being tested in this potentially crippling condition.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s1471-4892(02)00218-7" target="_blank" rel="noreferrer">10.1016/s1471-4892(02)00218-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Backlog
Bone Density/drug effects
Clodronate
Current Opinion in Pharmacology
Devogelaer JP
Diphosphonates/pharmacology/therapeutic use
Humans
Journal Article
Osteogenesis Imperfecta/classification/diagnosis/drug therapy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1046/j.1440-1754.2003.00083.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1440-1754.2003.00083.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Use of bisphosphonate therapy for osteoporosis in childhood and adolescence
Publisher
An entity responsible for making the resource available
Journal Of Paediatrics And Child Health
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; Male; Follow-Up Studies; Treatment Outcome; Severity of Illness Index; Risk Assessment; Drug Administration Schedule; adolescent; Preschool; Dose-Response Relationship; Drug; Clodronate; Bone Density; Densitometry; Diphosphonates/adverse effects/therapeutic use; Osteoporosis/diagnosis/drug therapy; X-Ray
Creator
An entity primarily responsible for making the resource
Batch JA; Couper JJ; Rodda C; Cowell CT; Zacharin M
Description
An account of the resource
Congenital and acquired forms of osteoporosis in childhood and adolescence can result in morbidity from fracture and pain in childhood, and place an individual at significant risk for problems in adult life. A range of therapies exist for the prevention and treatment of osteoporosis, including optimization of daily calcium intake, adequate vitamin D status, weight-bearing exercise, treatment with sex steroids where delayed puberty is a problem and, more recently, use of bisphosphonate therapy. Intravenous pamidronate therapy (a bisphosphonate) has been shown to reduce fractures and improve bone density in children with osteogenesis imperfecta, and might prove to be of benefit in other osteoporotic conditions in childhood. However, a number of issues regarding the optimal use of bisphosphonate therapy in children and adolescents remain to be resolved, including total annual dose and frequency and duration of administration. Bisphosphonate therapy should, therefore, be used only in the context of a well-run clinical programme with specialist knowledge in the management of osteopenic disorders in childhood.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1440-1754.2003.00083.x" target="_blank" rel="noreferrer">10.1046/j.1440-1754.2003.00083.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adolescent
Backlog
Batch JA
Bone Density
Child
Clodronate
Couper JJ
Cowell CT
Densitometry
Diphosphonates/adverse effects/therapeutic use
Dose-Response Relationship
Drug
Drug Administration Schedule
Female
Follow-up Studies
Humans
Journal Article
Journal of Paediatrics and Child Health
Male
Osteoporosis/diagnosis/drug therapy
Preschool
Risk Assessment
Rodda C
Severity Of Illness Index
Treatment Outcome
X-Ray
Zacharin M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/01.bpb.0000049567.52224.fa" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.bpb.0000049567.52224.fa</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modern approach to children with osteogenesis imperfecta
Publisher
An entity responsible for making the resource available
Journal Of Pediatric Orthopaedics. Part B / European Paediatric Orthopaedic Society, Pediatric Orthopaedic Society Of North America
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; Male; Prognosis; Treatment Outcome; Severity of Illness Index; Risk Assessment; Biopsy; Combined Modality Therapy; Preschool; infant; Needle; Clodronate; Diphosphonates/therapeutic use; Immunohistochemistry; Bone Density/physiology; Physical Therapy Modalities; Orthopedic Fixation Devices; Orthopedic Procedures/instrumentation/methods; Osteogenesis Imperfecta/pathology/therapy
Creator
An entity primarily responsible for making the resource
Zeitlin L; Fassier F; Glorieux FH
Description
An account of the resource
Osteogenesis Imperfecta (OI) is characterized by bone fragility. At least seven discrete types have been described ranging from mild disease to a lethal form. In a large number of cases, mutations in one of the two genes encoding type I collagen have been found. In forms recently described (types V, VI, VII), such mutations have been excluded. In two other forms, (Bruck, and osteoporosis - pseudoglioma syndromes) defects in other proteins have been characterized. In OI, bone fragility stems from: decreased bone mass, disturbed organization of bone tissue, and altered bone geometry (size and shape). Histologic studies have shown that increased bone turnover is the rule in OI bone. This justifies using bisphosphonates in order to reduce osteoclast mediated bone resorption. Initial results are encouraging. Cyclical intravenous pamidronate administration reduces bone pain and fracture incidence, and increases bone density and level of ambulation, with minimal side effects. Effects on bone include increase in size of vertebral bodies and thickening of cortical bone. These results allow for more efficacious corrective surgery using intramedullary rodding of the long bones and paravertegral instrumentation. Specific occupational and physiotherapy programs are integral parts of the treatment protocol. This multidisciplinary approach will prevail until strategies aiming at the correction of the basic defect(s) will have come to fruition.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.bpb.0000049567.52224.fa" target="_blank" rel="noreferrer">10.1097/01.bpb.0000049567.52224.fa</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Backlog
Biopsy
Bone Density/physiology
Child
Clodronate
Combined Modality Therapy
Diphosphonates/therapeutic use
Fassier F
Female
Glorieux FH
Humans
Immunohistochemistry
Infant
Journal Article
Journal Of Pediatric Orthopaedics. Part B / European Paediatric Orthopaedic Society, Pediatric Orthopaedic Society Of North America
Male
Needle
Orthopedic Fixation Devices
Orthopedic Procedures/instrumentation/methods
Osteogenesis Imperfecta/pathology/therapy
Physical Therapy Modalities
Preschool
Prognosis
Risk Assessment
Severity Of Illness Index
Treatment Outcome
Zeitlin L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1542/peds.110.1.181" target="_blank" rel="noreferrer">http://doi.org/10.1542/peds.110.1.181</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Uses of drugs not described in the package insert (off-label uses)
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Humans; United States; United States Food and Drug Administration; Prescriptions; Organizational Policy; Drug; Clodronate; Drug Approval; Societies; Adverse Drug Reaction Reporting Systems/legislation & jurisprudence; Drug Labeling/legislation & jurisprudence; Internet/legislation & jurisprudence; Medical/standards; Pediatrics/legislation & jurisprudence/standards; Physician's Practice Patterns/legislation & jurisprudence
Creator
An entity primarily responsible for making the resource
Committee on Drugs - American Academy of Pediatrics
Description
An account of the resource
New regulatory initiatives have been designed to ensure that new drugs and biologicals include adequate pediatric labeling for the claimed indications at the time of, or soon after, approval. However, because such labeling may not immediately be available, off-label use (or use that is not included in the approved label) of therapeutic agents is likely to remain common in the practice of pediatrics. This policy statement was written to address questions practitioners have regarding off-label use. The purpose of off-label use is to benefit the individual patient. Practitioners may use their professional judgment to determine these uses. Practitioners should understand that the Food and Drug Administration does not regulate off-label use.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1542/peds.110.1.181" target="_blank" rel="noreferrer">10.1542/peds.110.1.181</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adverse Drug Reaction Reporting Systems/legislation & jurisprudence
Backlog
Child
Clodronate
Committee on Drugs - American Academy of Pediatrics
Drug
Drug Approval
Drug Labeling/legislation & jurisprudence
Humans
Internet/legislation & jurisprudence
Journal Article
Medical/standards
Organizational Policy
Pediatrics
Pediatrics/legislation & jurisprudence/standards
Physician's Practice Patterns/legislation & jurisprudence
Prescriptions
Societies
United States
United States Food and Drug Administration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.2165/00024677-200201040-00006" target="_blank" rel="noreferrer">http://doi.org/10.2165/00024677-200201040-00006</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modern therapy for Paget's disease of bone: focus on bisphosphonates
Publisher
An entity responsible for making the resource available
Treatments In Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Animals; Clodronate; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Antimetabolites/administration & dosage/adverse effects/therapeutic use; Osteitis Deformans/drug therapy
Creator
An entity primarily responsible for making the resource
Devogelaer JP
Description
An account of the resource
There has been a dramatic change in the therapeutic approach to patients with Paget's disease of bone over the last 40 years. In the 1960s, only symptomatic therapy could be given, with control of pain the main objective. Analgesics and nonsteroidal anti-inflammatory drugs were the most commonly used agents. From 1968 onwards, antiosteoclastic agents became available, including calcitonin, plicamycin (mithramycin) and etidronate (etidronic acid), a first-generation bisphosphonate. Limitations with these agents, including potentially deleterious effects on bone mineralization with etidronate (etidronic acid), has cleared the way for increasingly potent second- and third-generation bisphosphonates, including clodronate (clodronic acid), pamidronate (pamidronic acid), alendronate (alendronic acid) and risedronate (risedronic acid). Even more potent bisphosphonates will become available in the near future. With the newer bisphosphonates, there is some hope for long-term remission (if not definitive healing) of pagetic lesions, as well as prevention of long-term complications in both symptomatic and asymptomatic patients. Thus, indications for therapy have been extended to include younger patients to prevent bone deformity of the limbs and skull, leading to secondary osteoarthritis, facial deformities and potentially to sarcoma transformation; as well as to elderly patients to prevent bone fragility, leading to fracture, and pagetic vascular steal syndromes. The increased potency and longer duration of action of newer bisphosphonates more than compensates for their marginally increased cost compared with older bisphosphonates.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2165/00024677-200201040-00006" target="_blank" rel="noreferrer">10.2165/00024677-200201040-00006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Animals
Antimetabolites/administration & dosage/adverse effects/therapeutic use
Backlog
Clodronate
Devogelaer JP
Diphosphonates/administration & dosage/adverse effects/therapeutic use
Humans
Journal Article
Osteitis Deformans/drug therapy
Treatments In Endocrinology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/bf00350961" target="_blank" rel="noreferrer">http://doi.org/10.1007/bf00350961</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta
Publisher
An entity responsible for making the resource available
Skeletal Radiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
Subject
The topic of the resource
Child; Female; Humans; Follow-Up Studies; Clodronate; Diphosphonates/therapeutic use; Osteogenesis Imperfecta/drug therapy/radiography
Creator
An entity primarily responsible for making the resource
Devogelaer JP; Malghem J; Maldague B; Nagant de Deuxchaisnes C
Description
An account of the resource
A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.
1987
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00350961" target="_blank" rel="noreferrer">10.1007/bf00350961</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1987
Backlog
Child
Clodronate
Devogelaer JP
Diphosphonates/therapeutic use
Female
Follow-up Studies
Humans
Journal Article
Maldague B
Malghem J
Nagant de Deuxchaisnes C
Osteogenesis Imperfecta/drug therapy/radiography
Skeletal Radiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0221-8747(81)90044-8" target="_blank" rel="noreferrer">http://doi.org/10.1016/0221-8747(81)90044-8</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Diphosphonates: history and mechanisms of action
Publisher
An entity responsible for making the resource available
Metabolic Bone Disease & Related Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1981
Subject
The topic of the resource
Humans; Animals; Non-U.S. Gov't; Research Support; Clodronate; Bone Resorption/drug effects; Calcification; Calcinosis/drug therapy; Calcium Phosphates/metabolism; Clodronic Acid; Diphosphates/pharmacology; Diphosphonates/metabolism/pharmacology/therapeutic use; Etidronic Acid/pharmacology; Methylene Chloride; Physiologic/drug effects; Polyphosphates/pharmacology
Creator
An entity primarily responsible for making the resource
Fleisch H
Description
An account of the resource
The history of diphosphonates began with studies of inorganic pyrophosphate. This compound was found to occur in many biological fluids and inhibited the precipitation of calcium phosphates. It also slowed the transformation of amorphous calcium phosphate to its crystalline form, and inhibited crystal aggregation and dissolution. These observations suggested that it might be a compound of physiological or pathophysiological significance, perhaps in hypophosphatasia and in renal lithiasis. Diphosphonates are compounds where the P-O-P bond of pyrophosphate is replaced by a P-C-P bond. Many diphosphonates have been synthesized and tested and some relationship of their structure to the spectrum of biological effects has been observed. These analogues have similar properties to pyrophosphate, but unlike pyrophosphate they are resistant to enzymic degradation. Their experimental properties have led to their clinical development as bone scanning agents and in the treatment of disorders of ectopic mineralization and increased bone resorption.
1981
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0221-8747(81)90044-8" target="_blank" rel="noreferrer">10.1016/0221-8747(81)90044-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1981
Animals
Backlog
Bone Resorption/drug effects
Calcification
Calcinosis/drug therapy
Calcium Phosphates/metabolism
Clodronate
Clodronic Acid
Diphosphates/pharmacology
Diphosphonates/metabolism/pharmacology/therapeutic use
Etidronic Acid/pharmacology
Fleisch H
Humans
Journal Article
Metabolic Bone Disease & Related Research
Methylene Chloride
Non-U.S. Gov't
Physiologic/drug effects
Polyphosphates/pharmacology
Research Support
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0140-6736(69)92293-4" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0140-6736(69)92293-4</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Diphosphonates in the treatment of myositis ossificans
Publisher
An entity responsible for making the resource available
Lancet
Date
A point or period of time associated with an event in the lifecycle of the resource
1969
Subject
The topic of the resource
Child; Humans; Male; Depression; adolescent; Preschool; infant; Clodronate; Calcium/metabolism; Chemical; Myositis Ossificans/drug therapy/metabolism; Phosphonic Acids/therapeutic use
Creator
An entity primarily responsible for making the resource
Bassett CA; Donath A; Macagno F; Preisig R; Fleisch H; Francis MD
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0140-6736(69)92293-4" target="_blank" rel="noreferrer">10.1016/s0140-6736(69)92293-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1969
1969
Adolescent
Backlog
Bassett CA
Calcium/metabolism
Chemical
Child
Clodronate
Depression
Donath A
Fleisch H
Francis MD
Humans
Infant
Journal Article
Lancet
Macagno F
Male
Myositis Ossificans/drug therapy/metabolism
Phosphonic Acids/therapeutic use
Preisig R
Preschool
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/00003086-197610000-00018" target="_blank" rel="noreferrer">http://doi.org/10.1097/00003086-197610000-00018</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Diphosphonate treatment of Paget's disease
Publisher
An entity responsible for making the resource available
Clinical Orthopaedics and Related Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1976
Subject
The topic of the resource
Female; Humans; Male; Aged; Middle Aged; Clodronate; Alkaline Phosphatase/blood; Fractures; Bone/etiology; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Osteitis Deformans/drug therapy/metabolism/radiography; Osteomalacia/etiology; Proline/urine
Creator
An entity primarily responsible for making the resource
Finerman GA; Gonick HC; Smith RK; Mayfield JM
Description
An account of the resource
Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered in a dose of 20 mg/kg/d to 21 patients with symptomatic Paget's disease. All patients were treated for 6 months and then followed for an additional 6 months. There was a striking decline in serum alkaline phosphatase and urinary hydroxy-proline excretion observed after 3 months of therapy which was not significantly improved in the succeeding 3 months. Concomitantly there was marked improvement in clinical symptoms and bone scans. Following cessation of therapy, continued biochemical and clinical evidence of remission persisted. Several patients on repeat treatment with EHDP appeared to respond promptly. Side effects were minimal except for a possibly related osteomalacia and increased incidence of pathologic fractures.
1976
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003086-197610000-00018" target="_blank" rel="noreferrer">10.1097/00003086-197610000-00018</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1976
Aged
Alkaline Phosphatase/blood
Backlog
Bone/etiology
Clinical Orthopaedics and Related Research
Clodronate
Diphosphonates/administration & dosage/adverse effects/therapeutic use
Female
Finerman GA
Fractures
Gonick HC
Humans
Journal Article
Male
Mayfield JM
Middle Aged
Osteitis Deformans/drug therapy/metabolism/radiography
Osteomalacia/etiology
Proline/urine
Smith RK
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.7326/0003-4819-112-4-293" target="_blank" rel="noreferrer">http://doi.org/10.7326/0003-4819-112-4-293</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience
Publisher
An entity responsible for making the resource available
Annals Of Internal Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
Subject
The topic of the resource
Female; Humans; Adult; Physician's Role; Research Design; Double-Blind Method; Patient Compliance; Clodronate; Randomized Controlled Trials/methods; Amitriptyline/therapeutic use; Propranolol/therapeutic use; Syncope/drug therapy
Creator
An entity primarily responsible for making the resource
Guyatt GH; Keller JL; Jaeschke R; Rosenbloom D; Adachi JD; Newhouse MT
Description
An account of the resource
OBJECTIVE: To review the feasibility and effectiveness of n-of-1 randomized controlled trials (n-of-1 trials) in clinical practice. DESIGN: Individual trials were double-blind, randomized, multiple crossover trials. The impact of n-of-1 trials was determined by eliciting physicians' plans of management and confidence in those plans before and after each trial. SETTING: Referral service doing n-of-1 trials at the requests of community and academic physicians. OBJECT of ANALYSIS: All trials were planned, started, and completed by the n-of-1 service. MEASURES of OUTCOME: The proportion of planned n-of-1 trials that were completed and the proportion that provided a definite clinical or statistical answer. A definite clinical answer was achieved if an n-of-1 trial resulted in a high level of physician's confidence in the management plan. Specific criteria were developed for classifying an n-of-1 trial as providing a definite statistical answer. MAIN RESULTS: Seventy-three n-of-1 trials were planned in various clinical situations. Of 70 n-of-1 trials begun, 57 were completed. The reasons for not completing n-of-1 trials were patients' or physicians' noncompliance or patients' concurrent illness. Of 57 n-of-1 trials completed, 50 provided a definite clinical or statistical answer. In 15 trials (39% of trials in which appropriate data were available), the results prompted physicians to change their "prior to the trial" plan of management (in 11 trials, the physicians stopped the drug therapy that they had planned to continue indefinitely). CONCLUSION: We interpret the results as supporting the feasibility and usefulness of n-of-1 trials in clinical practice.
1990
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.7326/0003-4819-112-4-293" target="_blank" rel="noreferrer">10.7326/0003-4819-112-4-293</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1990
Adachi JD
Adult
Amitriptyline/therapeutic use
Annals Of Internal Medicine
Backlog
Clodronate
Double-Blind Method
Female
Guyatt GH
Humans
Jaeschke R
Journal Article
Keller JL
Newhouse MT
Patient Compliance
Physician's Role
Propranolol/therapeutic use
Randomized Controlled Trials/methods
Research Design
Rosenbloom D
Syncope/drug therapy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0885-3924(92)90101-m" target="_blank" rel="noreferrer">http://doi.org/10.1016/0885-3924(92)90101-m</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A double-blind, crossover trial of intravenous clodronate in metastatic bone pain
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
The topic of the resource
Female; Humans; Male; Pain Measurement; Adult; Aged; Middle Aged; Double-Blind Method; 80 and over; Infusions; Intravenous; Clodronate; Clodronic Acid/administration & dosage/therapeutic use; Bone Neoplasms/physiopathology/secondary; Pain/diagnosis/drug therapy/etiology
Creator
An entity primarily responsible for making the resource
Ernst DS; MacDonald RN; Paterson AH; Jensen J; Brasher P; Bruera E
Description
An account of the resource
After a baseline symptom and laboratory assessment, 24 patients with metastatic bone disease and pain were randomized to receive either a 4-hr intravenous infusion of 2-dichloromethylene bisphosphonate (Cl2MDP), 600 mg in 500 mL of normal saline, or a 4-hr placebo infusion, 500 mL of normal saline. The administration was double blind. After 1 wk, the assessment was repeated and the patients were crossed over to the alternate treatment. After 1 more wk, a final assessment and blinded choice by the patient and investigator took place. Of the 21 evaluable patients, 12 (57%) chose the Cl2MDP and 4 (19%) chose the placebo; 5 (24%) patients did not have a specific preference (p = NS). The investigator chose the Cl2MDP in 14 (67%) cases, placebo in 6 (29%) cases and was unable to discern a difference in 1 (5%) case (p less than 0.05). The patients and investigator made similar selections in 16 (76%) instances. On the visual analogue scale assessments, a significant decrease in pain scores was observed following the Cl2MDP infusion (p less than 0.01) and an increase in activity scores was also demonstrated (p less than 0.01). No significant difference in the daily oral morphine equivalent analgesic requirement was demonstrated for either arm. No difference in clinical and laboratory parameters of toxicity was evident between the placebo and Cl2MDP arms of the trial. Our preliminary findings suggest that Cl2MDP is safe, and has analgesic properties that may prove to be useful in the management of metastatic bone pain.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0885-3924(92)90101-m" target="_blank" rel="noreferrer">10.1016/0885-3924(92)90101-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
80 And Over
Adult
Aged
Backlog
Bone Neoplasms/physiopathology/secondary
Brasher P
Bruera E
Clodronate
Clodronic Acid/administration & dosage/therapeutic use
Double-Blind Method
Ernst DS
Female
Humans
Infusions
Intravenous
Jensen J
Journal Article
Journal of Pain and Symptom Management
MacDonald RN
Male
Middle Aged
Pain Measurement
Pain/diagnosis/drug therapy/etiology
Paterson AH
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/8756-3282(95)00445-9" target="_blank" rel="noreferrer">http://doi.org/10.1016/8756-3282(95)00445-9</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonates: a review of their pharmacokinetic properties
Publisher
An entity responsible for making the resource available
Bone
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
Subject
The topic of the resource
Humans; Animals; Protein Binding; Dose-Response Relationship; Drug; Clodronate; Structure-Activity Relationship; Biological Availability; Blood Proteins/metabolism; Diphosphonates/pharmacokinetics/urine; Intestinal Absorption/physiology; Tissue Distribution/physiology
Creator
An entity primarily responsible for making the resource
Lin JH
Description
An account of the resource
Bisphosphonates are a unique class of drugs. As a family, they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution, and elimination. Although all bisphosphonates have similar physicochemical properties, their antiresorbing activities differ substantially. Activity is dramatically increased when the amino group is contained in the aliphatic carbon chain. For example, alendronate, an aminobisphosphonate, is approximately 700-fold more potent than etidronate, both in vitro and in vivo. In general, bisphosphonates are poorly absorbed from the gastrointestinal tract as a result of their poor lipophilicity. In vitro and in vivo studies have shown that bisphosphonates are absorbed from the gastrointestinal tract via paracellular transport. Systemically available bisphosphonates disappear very rapidly from plasma, and are partly taken up by the bone and partly excreted by the kidney. The relative contribution of these two processes to overall plasma elimination differs significantly among bisphosphonates. To date, all bisphosphonates studied show no evidence of metabolism. Renal excretion is the only route of elimination. Studies with alendronate in rats indicate that the drug is actively secreted by an uncharacterized renal transport system, and not by the anionic or cationic renal transport systems. Bisphosphonates bind preferentially to bones which have high turnover rates, and their distribution in bone is not homogeneous. After bone uptake, the bisphosphonates are liberated again only when the bone in which they are deposited is resorbed. Thus, the half-life of bisphosphonates in bone is very long, ranging among different species from 1 to 10 years, depending largely on the rate of bone turnover.
1996
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/8756-3282(95)00445-9" target="_blank" rel="noreferrer">10.1016/8756-3282(95)00445-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1996
Animals
Backlog
Biological Availability
Blood Proteins/metabolism
Bone
Clodronate
Diphosphonates/pharmacokinetics/urine
Dose-Response Relationship
Drug
Humans
Intestinal Absorption/physiology
Journal Article
Lin JH
Protein Binding
Structure-Activity Relationship
Tissue Distribution/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0022-3476(99)70447-6" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0022-3476(99)70447-6</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Expanding role of bisphosphonate therapy in children
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Child; Humans; Clodronate; Calcinosis/drug therapy; Bone Diseases/drug therapy; Diphosphonates/pharmacokinetics/pharmacology/therapeutic use; Hypercalcemia/drug therapy
Creator
An entity primarily responsible for making the resource
Shoemaker LR
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0022-3476(99)70447-6" target="_blank" rel="noreferrer">10.1016/s0022-3476(99)70447-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1999
1999
Backlog
Bone Diseases/drug therapy
Calcinosis/drug therapy
Child
Clodronate
Diphosphonates/pharmacokinetics/pharmacology/therapeutic use
Humans
Hypercalcemia/drug therapy
Journal Article
Shoemaker LR
The Journal Of Pediatrics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(97)00075-4" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(97)00075-4</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Female; Humans; Male; Pain; Adult; Analgesics; Aged; Middle Aged; Treatment Outcome; Analysis of Variance; Chi-Square Distribution; Cross-Over Studies; 80 and over; Comparative Study; Injections; Intravenous; Dose-Response Relationship; Drug; Clodronate; Pain Measurement/drug effects; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage; Intractable/drug therapy/etiology; Bone Neoplasms/complications/secondary
Creator
An entity primarily responsible for making the resource
Ernst DS; Brasher P; Hagen N; Paterson AH; MacDonald RN; Bruera E
Description
An account of the resource
To evaluate the effectiveness of intravenous clodronate in ameliorating refractory bone pain in patients with metastatic bone disease, 60 patients with established osseous metastases and persistent bone pain were randomized to receive either clodronate (600 mg or 1500 mg in 500 mL of normal saline) or 500 mL of saline as placebo. After 2 weeks, the patients were crossed over to receive the alternate treatment. After another 2 weeks, each patient and investigator made a blinded choice. Daily visual analogue scales (VAS) and analgesic diaries were recorded throughout the study period. Forty-six patients were evaluable (77%). A treatment x period interaction was identified in the VAS and daily morphine equivalent dose (DMED) scores. First period analysis of the VAS scores for general pain, pain at rest, and pain upon movement demonstrated an average reduction of 13, 14, and 24 mm, respectively, from baseline, but were not significantly different from changes following placebo. The average change in DMED was -6.4 (SE = 2.9) following clodronate and was +24.6 (SE = 14.9) following placebo (p = 0.03). In the blinded choice of which agent resulted in improvement in pain, 26 (57%) patients chose clodronate, 12 (26%) chose placebo, and eight (17%) had no preference (p = 0.0021). For the investigators who also made a blinded selection, clodronate was chosen in 30 (65%) patients, placebo in ten (22%) patients, and no difference was apparent in six (13%) (p < 0.0001). Intravenous clodronate appeared to have analgesic effect in patients with refractory bone pain due to metastatic bone disease. The optimal dose and duration of effect require further evaluation, particularly in patients with stable disease and persistent bone pain.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(97)00075-4" target="_blank" rel="noreferrer">10.1016/s0885-3924(97)00075-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
80 And Over
Adult
Aged
Analgesics
Analysis of Variance
Backlog
Bone Neoplasms/complications/secondary
Brasher P
Bruera E
Chi-Square Distribution
Clodronate
Clodronic Acid/administration & dosage
Comparative Study
Cross-Over Studies
Dose-Response Relationship
Drug
Ernst DS
Female
Hagen N
Humans
Injections
Intractable/drug therapy/etiology
Intravenous
Journal Article
Journal of Pain and Symptom Management
MacDonald RN
Male
Middle Aged
Non-Narcotic/administration & dosage
Pain
Pain Measurement/drug effects
Paterson AH
Treatment Outcome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1023/a:1008274608267" target="_blank" rel="noreferrer">http://doi.org/10.1023/a:1008274608267</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Subcutaneous clodronate: a study evaluating efficacy in hypercalcemia of malignancy and local toxicity
Publisher
An entity responsible for making the resource available
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Female; Humans; Male; Aged; Middle Aged; 80 and over; Injections; Neoplasms/complications; Subcutaneous; Clodronate; Hypercalcemia/drug therapy; Clodronic Acid/administration & dosage/adverse effects
Creator
An entity primarily responsible for making the resource
Walker P; Watanabe S; Lawlor P; Hanson J; Pereira J; Bruera E
Description
An account of the resource
The logistics of administering intravenous bisphosphonates may be problematic in the care of advanced cancer patients, especially in the home setting. Hypodermoclysis is a convenient method of administering fluid via subcutaneous infusion, presently used in the domiciliary setting. Results of the administration of clodronate via this route are reported.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1023/a:1008274608267" target="_blank" rel="noreferrer">10.1023/a:1008274608267</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
80 And Over
Aged
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo
Backlog
Bruera E
Clodronate
Clodronic Acid/administration & dosage/adverse effects
Female
Hanson J
Humans
Hypercalcemia/drug therapy
Injections
Journal Article
Lawlor P
Male
Middle Aged
Neoplasms/complications
Pereira J
Subcutaneous
Walker P
Watanabe S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/nejm199810013391402" target="_blank" rel="noreferrer">http://doi.org/10.1056/nejm199810013391402</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cyclic administration of pamidronate in children with severe osteogenesis imperfecta
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Child; Female; Humans; Male; Drug Administration Schedule; adolescent; Preschool; Non-U.S. Gov't; Research Support; Pain/drug therapy; Clodronate; Bone Density/drug effects; Periodicity; Diphosphonates/administration & dosage; Alkaline Phosphatase/blood; Bone Development/drug effects; Bone Resorption/drug therapy; Bone/prevention & control; Calcium/urine; Fractures; Lumbar Vertebrae/physiopathology/radiography; Osteogenesis Imperfecta/drug therapy/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Glorieux FH; Bishop NJ; Plotkin H; Chabot G; Lanoue G; Travers R
Description
An account of the resource
BACKGROUND: Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We assessed the effects of treatment with a bisphosphonate on bone resorption. METHODS: In an uncontrolled observational study involving 30 children who were 3 to 16 years old and had severe osteogenesis imperfecta, we administered pamidronate intravenously (mean [+/-SD] dose, 6.8+/-1.1 mg per kilogram of body weight per year) at 4-to-6-month intervals for 1.3 to 5.0 years. Clinical status, biochemical characteristics reflecting bone turnover, the bone mineral density of the lumbar spine, and radiologic changes were assessed regularly during treatment. RESULTS: Administration of pamidronate resulted in sustained reductions in serum alkaline phosphatase concentrations and in the urinary excretion of calcium and type I collagen N-telopeptide. There was a mean annualized increase of 41.9+/-29.0 percent in bone mineral density, and the deviation of bone mineral density from normal, as indicated by the z score, improved from -5.3+/-1.2 to -3.4+/-1.5. The cortical width of the metacarpals increased by 27+/-20.2 percent per year. The increases in the size of the vertebral bodies suggested that new bone had formed. The mean incidence of radiologically confirmed fractures decreased by 1.7 per year (P<0.001). Treatment with pamidronate did not alter the rate of fracture healing, the growth rate, or the appearance of the growth plates. Mobility and ambulation improved in 16 children and remained unchanged in the other 14. All the children reported substantial relief of chronic pain and fatigue. CONCLUSIONS: In children with severe osteogenesis imperfecta, cyclic administration of intravenous pamidronate improved clinical outcomes, reduced bone resorption, and increased bone density.
1998
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/nejm199810013391402" target="_blank" rel="noreferrer">10.1056/nejm199810013391402</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1998
Adolescent
Alkaline Phosphatase/blood
Backlog
Bishop NJ
Bone Density/drug effects
Bone Development/drug effects
Bone Resorption/drug therapy
Bone/prevention & control
Calcium/urine
Chabot G
Child
Clodronate
Diphosphonates/administration & dosage
Drug Administration Schedule
Female
Fractures
Glorieux FH
Humans
Journal Article
Lanoue G
Lumbar Vertebrae/physiopathology/radiography
Male
Non-U.S. Gov't
Osteogenesis Imperfecta/drug therapy/metabolism/physiopathology
Pain/drug Therapy
Periodicity
Plotkin H
Preschool
Research Support
The New England Journal Of Medicine
Travers R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1067/mpd.2000.107838" target="_blank" rel="noreferrer">http://doi.org/10.1067/mpd.2000.107838</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Osteoporosis pseudoglioma syndrome: treatment of spinal osteoporosis with intravenous bisphosphonates
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Child; Female; Humans; Male; Analgesics; Growth; Non-U.S. Gov't; Research Support; Syndrome; Infusions; Intravenous; Clodronate; Pain/prevention & control; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage; Diphosphonates/administration & dosage; Fractures; Bone Density/physiology; Bone/complications/physiopathology; Osteoporosis/complications/drug therapy/physiopathology; Spine/physiopathology; Vision Disorders/complications
Creator
An entity primarily responsible for making the resource
Zacharin M; Cundy T
Description
An account of the resource
OBJECTIVES: To determine whether intravenous bisphosphonate treatment is helpful for children with osteoporosis pseudoglioma syndrome who have severe osteoporosis. METHODS: Three children (ages 9 to 11 years) with osteoporosis pseudoglioma syndrome who had multiple vertebral collapse were treated over a 2-year period with intermittent intravenous bisphosphonate infusions (pamidronate in 2, clodronate in 1). The responses to therapy were assessed with clinical and radiographic evaluation and bone densitometry of the spine. RESULTS: All 3 subjects reported early reductions in bone pain and improved mobility. Radiographs showed dense new bone in the vertebral end plates and remodeling of the vertebral bodies. Areal bone mineral density at the lumbar spine (age-appropriate SD score) improved from a mean of -4.5 before treatment to -2.8 after 2 years (P <.05). No new fractures occurred, and side effects were minimal. Growth and pubertal development proceeded normally. CONCLUSIONS: Intravenous bisphosphonate therapy appears safe and beneficial in patients with this condition and may prevent progressive vertebral deformity.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1067/mpd.2000.107838" target="_blank" rel="noreferrer">10.1067/mpd.2000.107838</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Analgesics
Backlog
Bone Density/physiology
Bone/complications/physiopathology
Child
Clodronate
Clodronic Acid/administration & dosage
Cundy T
Diphosphonates/administration & dosage
Female
Fractures
Growth
Humans
Infusions
Intravenous
Journal Article
Male
Non-Narcotic/administration & dosage
Non-U.S. Gov't
Osteoporosis/complications/drug therapy/physiopathology
Pain/prevention & control
Research Support
Spine/physiopathology
Syndrome
The Journal Of Pediatrics
Vision Disorders/complications
Zacharin M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1177/000992289903801201" target="_blank" rel="noreferrer">http://doi.org/10.1177/000992289903801201</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonates: from grandparents to grandchildren
Publisher
An entity responsible for making the resource available
Clinical Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Child; Female; Humans; Male; Adult; Aged; Middle Aged; Age Factors; adolescent; Preschool; Non-U.S. Gov't; Research Support; Administration; Oral; Clodronate; Bone Diseases/drug therapy; Hypercalcemia/drug therapy; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Osteogenesis Imperfecta/drug therapy; Osteoporosis; Postmenopausal/drug therapy
Creator
An entity primarily responsible for making the resource
Srivastava T; Alon US
Description
An account of the resource
Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. Bisphosphonates have been extensively used in the elderly with primary and secondary osteoporosis, Paget's disease, and hypercalcemia of malignancy. In recent years, bisphosphonates have been used to treat children acutely for resistant hypercalcemia and chronically for various metabolic bone diseases. The theoretical concerns of possible adverse effects of these drugs on the growing skeleton have not been proven to be true. In the present review, we have critically analyzed the available literature on bisphosphonate therapy in both adult and pediatric clinical trials. Although not yet approved by the FDA for use in children, bisphosphonates, from published experience, demonstrate benefit to the child with no serious adverse effects. Based on the literature analysis the review furnishes detailed recommendations and practical guidelines regarding the use of oral and intravenous bisphosphonates in children. Bisphosphonates might be the first agents to provide the pediatrician with an opportunity to treat mineral and bone disorders of childhood, which until recently did not have satisfactory therapy.
1999
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/000992289903801201" target="_blank" rel="noreferrer">10.1177/000992289903801201</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Administration
Adolescent
Adult
Age Factors
Aged
Alon US
Backlog
Bone Diseases/drug therapy
Child
Clinical Pediatrics
Clodronate
Diphosphonates/administration & dosage/adverse effects/therapeutic use
Female
Humans
Hypercalcemia/drug therapy
Journal Article
Male
Middle Aged
Non-U.S. Gov't
Oral
Osteogenesis Imperfecta/drug therapy
Osteoporosis
Postmenopausal/drug therapy
Preschool
Research Support
Srivastava T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1191/026921600701536372" target="_blank" rel="noreferrer">http://doi.org/10.1191/026921600701536372</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care
Publisher
An entity responsible for making the resource available
Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Female; Humans; Male; Evidence-Based Medicine; Practice Guidelines; Palliative Care/standards; Clodronate; Diphosphonates/therapeutic use; Pain/prevention & control; Prostatic Neoplasms; Bone Neoplasms/secondary; Breast Neoplasms; Multiple Myeloma
Creator
An entity primarily responsible for making the resource
Mannix K; Ahmedzai SH; Anderson H; Bennett M; Lloyd-Williams M; Wilcock A
Description
An account of the resource
This work was undertaken by the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland (APM) as a demonstration project in developing clinical guidelines relevant to palliative care from a pragmatic approach to literature review and grading of clinical evidence. CANCERLIT and Embase were searched for relevant papers written in English, published since 1980. Each study identified was rated against agreed criteria for levels of evidence. Most studies were not specifically designed to define speed of response, and were not undertaken in palliative care patients. Thus, careful reading and grading of each study was necessary. Sufficient evidence was identified to make recommendations for clinical practice in a palliative care population of patients, and areas for future research have been identified. Bisphosphonates appear to have a role in managing pain from metastases which has been refractory to conventional analgesic management and where oncological or orthopaedic intervention is delayed or inappropriate.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1191/026921600701536372" target="_blank" rel="noreferrer">10.1191/026921600701536372</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Ahmedzai SH
Anderson H
Backlog
Bennett M
Bone Neoplasms/secondary
Breast Neoplasms
Clodronate
Diphosphonates/therapeutic use
Evidence-based Medicine
Female
Humans
Journal Article
Lloyd-Williams M
Male
Mannix K
Multiple Myeloma
Pain/prevention & control
Palliative Care/standards
Palliative Medicine
Practice Guidelines
Prostatic Neoplasms
Wilcock A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1203/00006450-199804001-00475" target="_blank" rel="noreferrer">http://doi.org/10.1203/00006450-199804001-00475</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonates for treatment of childhood hypercalcemia
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Child; Female; Humans; Leukemia; adolescent; Preschool; Clodronate; Diphosphonates/therapeutic use; Acute; Lymphocytic; Calcium/blood; Hypercalcemia/drug therapy/etiology; Immobilization/adverse effects; L1/complications
Creator
An entity primarily responsible for making the resource
Lteif AN; Zimmerman D
Description
An account of the resource
Most clinicians only have a limited experience in treating childhood hypercalcemia with bisphosphonates. We report our experience in the use of intravenous and oral bisphosphonates in a 5-year-old with hypercalcemia secondary to acute lymphocytic leukemia, a 16-year-old with immobilization hypercalcemia, and a 14-year-old with chronic hypercalcemia of unknown cause. Single infusions of 0.5 mg/kg and 1 mg/kg of intravenous pamidronate were administered over 4 hours. No adverse reactions were observed except for hypocalcemia. A dose between 10 and 20 mg of oral alendronate was successfully used to maintain normocalcemia in the patient with chronic hypercalcemia. In our experience, the administration of bisphosphonates has enabled us to achieve normocalcemia in all cases, and in all cases there were no significant side effects. Long-term potential side effects from their use in children during the active phase of growth remain unknown.
1998
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1203/00006450-199804001-00475" target="_blank" rel="noreferrer">10.1203/00006450-199804001-00475</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1998
Acute
Adolescent
Backlog
Calcium/blood
Child
Clodronate
Diphosphonates/therapeutic use
Female
Humans
Hypercalcemia/drug therapy/etiology
Immobilization/adverse effects
Journal Article
L1/complications
Leukemia
Lteif AN
Lymphocytic
Pediatrics
Preschool
Zimmerman D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1210/er.19.1.80" target="_blank" rel="noreferrer">http://doi.org/10.1210/er.19.1.80</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonates: mechanisms of action
Publisher
An entity responsible for making the resource available
Endocrine Reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Humans; Animals; Clodronate; Diphosphonates/chemistry/metabolism/pharmacology; Bone Development/drug effects; Bone Resorption/physiopathology
Creator
An entity primarily responsible for making the resource
Fleisch H
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/er.19.1.80" target="_blank" rel="noreferrer">10.1210/er.19.1.80</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1998
1998
Animals
Backlog
Bone Development/drug effects
Bone Resorption/physiopathology
Clodronate
Diphosphonates/chemistry/metabolism/pharmacology
Endocrine Reviews
Fleisch H
Humans
Journal Article
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/NEJM200002033420506" target="_blank" rel="noreferrer">http://doi.org/10.1056/NEJM200002033420506</a>
<a href="http://dx.doi.org/10.1056/NEJM200002033420506" target="_blank" rel="noreferrer">http://dx.doi.org/10.1056/NEJM200002033420506</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Symptoms and Suffering at the End of Life in Children with Cancer
Publisher
An entity responsible for making the resource available
New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Child; Humans; Terminal Care; Health Care Surveys; Parents; Withholding Treatment; Logistic Models; Questionnaires; Physicians; Boston; Longitudinal Studies; Quality of Health Care; quality of life; Empirical Approach; Non-U.S. Gov't; P.H.S.; Professional Patient Relationship; Research Support; U.S. Gov't; Death and Euthanasia; Psychological; Stress; Clodronate; Neoplasms/complications/therapy; Oncology at EOL; Pain/etiology/therapy; Anorexia/etiology/therapy; home care services; Children's Hospital (Boston); Constipation/etiology/therapy; Dana-Farber Cancer Institute (Boston); Diarrhea/etiology/therapy; Dyspnea/etiology/therapy; Fatigue/etiology/therapy; Palliative Care/standards/statistics & numerical data
Creator
An entity primarily responsible for making the resource
Wolfe J; Grier Holcombe E; Klar Neil; Levin SB; Ellenbogen JM; Salem-Schatz S; Emanuel EJ; Weeks Jane C
Description
An account of the resource
Cancer is the leading cause of nonaccidental death in childhood.1 There has, however, been little evaluation of the overall experience at the end of life of children who are dying of cancer or of their symptoms other than pain.2,3 A number of studies have demonstrated that among adults, the quality of care at the end of life is suboptimal.4–8 For example, one study of elderly patients found that there was considerable suffering at the end of life, with up to 25 percent of patients experiencing moderate-to-severe pain in the last three days of life.7 It is not known . . .
2000-02
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/NEJM200002033420506" target="_blank" rel="noreferrer">10.1056/NEJM200002033420506</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Anorexia/etiology/therapy
Backlog
Boston
Child
Children's Hospital (Boston)
Clodronate
Constipation/etiology/therapy
Dana-Farber Cancer Institute (Boston)
Death and Euthanasia
Diarrhea/etiology/therapy
Dyspnea/etiology/therapy
Ellenbogen JM
Emanuel EJ
Empirical Approach
Fatigue/etiology/therapy
Grier Holcombe E
Health Care Surveys
home care services
Humans
Journal Article
Klar Neil
Levin SB
Logistic Models
Longitudinal Studies
Neoplasms/complications/therapy
New England Journal Of Medicine
Non-U.S. Gov't
Oncology at EOL
P.H.S.
Pain/etiology/therapy
Palliative Care/standards/statistics & Numerical Data
Parents
Physicians
Professional Patient Relationship
Psychological
Quality Of Health Care
Quality Of Life
Questionnaires
Research Support
Salem-Schatz S
Stress
Terminal Care
U.S. Gov't
Weeks Jane C
Withholding Treatment
Wolfe J