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Text
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URL Address
<a href="http://doi.org/10.1046/j.1440-1681.2000.03287.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1440-1681.2000.03287.x</a>
Dublin Core
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Title
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Pain control by immune-derived opioids
Publisher
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Clinical And Experimental Pharmacology & Physiology
Date
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2000
Subject
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Humans; Analgesics; Biomarkers of Pain; Receptors; Opioid/therapeutic use; Neuropeptides/therapeutic use; Opioid/drug effects/immunology; Pain/drug therapy/immunology; Peripheral Nervous System/drug effects
Creator
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Machelska H; Stein C
Description
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1. The nervous and immune systems communicate with each other by use of cytokines and neuropeptides. 2. Interactions between immune cell-derived opioid peptides and opioid receptors located in peripheral inflamed tissue lead to endogenous analgesia. 3. In addition to their immunological functions, immunocytes are involved in intrinsic pain inhibition. This provides new insights into pain associated with a compromised immune system, as in AIDS or in cancer. 4. The activation of opioid production and release from immune cells may be a novel approach to the development of peripherally acting analgesics. Because such drugs would be targeted towards events in peripheral injured tissue, these analgesics should lack unwanted central side effects typically associated with opioids.
2000
Identifier
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<a href="http://doi.org/10.1046/j.1440-1681.2000.03287.x" target="_blank" rel="noreferrer">10.1046/j.1440-1681.2000.03287.x</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2000
Analgesics
Backlog
Biomarkers of Pain
Clinical And Experimental Pharmacology & Physiology
Humans
Journal Article
Machelska H
Neuropeptides/therapeutic use
Opioid/drug effects/immunology
Opioid/therapeutic use
Pain/drug therapy/immunology
Peripheral Nervous System/drug effects
Receptors
Stein C