1
40
4
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/mgme.1999.2815" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/mgme.1999.2815</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Melatonin ineffective in neuronal ceroid lipofuscinosis patients with fragmented or normal motor activity rhythms recorded by wrist actigraphy
Publisher
An entity responsible for making the resource available
Molecular Genetics and Metabolism
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Adolescent; Adult; Antioxidants/tu [Therapeutic Use]; Child; Circadian Rhythm; Dose-Response Relationship; Drug Electrophysiology; Female; Humans; Male; Melatonin/tu [Therapeutic Use]; Neuronal Ceroid-Lipofuscinoses/dt [Drug Therapy]; Sleep Wake Disorders/th [Therapy]; 0 (Antioxidants); JL5DK93RCL (Melatonin); sleep disturbance/disorders; NCL3; pharmacologic intervention; melatonin
Creator
An entity primarily responsible for making the resource
Hätönen T; Kirveskari E; Heiskala H; Sainio K; Laakso M L; Santavuori P
Description
An account of the resource
Melatonin was tested as a sleeping pill in five patients with neuronal ceroid lipofuscinoses. The single-blind, placebo-controlled study consisted of motor activity recordings, sleep logs, and administration of placebo or melatonin (2.5 or 5 mg). Daily motor activity rhythms were measured by wrist actigraphy during four 7-day periods (baseline, placebo, melatonin 2.5 mg, and melatonin 5 mg). The placebo or melatonin was administered in the evenings for 3 weeks, and the recordings were made during the last week of the 3-week treatment. Sleep logs were kept by the caregivers during the recordings. Based on period analyses, the activity recordings were evaluated to display a normal (24-h) or fragmented rhythm. Three patients had normal motor activity patterns during the baseline recordings, and administration of placebo or melatonin did not affect their rest/activity rhythms. Two patients had abnormally fragmented activity rhythms during the baseline periods, and administration of placebo or melatonin did not induce synchronization. According to the actigraphic data, there were no changes in activity rhythms resulting from administration of melatonin. However, based on the observations, three families reported that melatonin slightly improved the sleep quality of the patients. These controversial findings show the difficulties involved in specifying the role of melatonin in modulating sleep. Thus, we conclude that more evidence is required before the significance of melatonin as a sleeping pill is defined.Copyright 1999 Academic Press.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/mgme.1999.2815" target="_blank" rel="noreferrer noopener">10.1006/mgme.1999.2815</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
0 (Antioxidants)
1999
Adolescent
Adult
Antioxidants/tu [Therapeutic Use]
Child
Circadian Rhythm
Dose-Response Relationship
Drug Electrophysiology
Female
Hätönen T
Heiskala H
Humans
JL5DK93RCL (Melatonin)
Kirveskari E
Laakso M L
Male
melatonin
Melatonin/tu [Therapeutic Use]
Molecular Genetics and Metabolism
NCL3
Neuronal Ceroid-Lipofuscinoses/dt [Drug Therapy]
pharmacologic intervention
Sainio K
Santavuori P
sleep disturbance/disorders
Sleep Wake Disorders/th [Therapy]
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/08830738050200010301" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/08830738050200010301</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin
Publisher
An entity responsible for making the resource available
Journal of Child Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Circadian Rhythm; Male; Case-Control Studies; Child; Humans; Adolescent; Female; Child Preschool; Administration Oral; Reference Values; Tuberous Sclerosis; Antioxidants; Melatonin; Sleep Wake Disorders; Antioxidants/pk [Pharmacokinetics]; Circadian Rhythm; Melatonin/aa [Analogs & Derivatives]; Melatonin/pk [Pharmacokinetics]; Sleep Wake Disorders/co [Complications]; Tuberous Sclerosis/co [Complications]; 0 (Antioxidants); 2208-40-4 (6-sulfatoxymelatonin); Antioxidants/ad [Administration & Dosage]; JL5DK93RCL (Melatonin); Melatonin/ad [Administration & Dosage]; Melatonin/ur [Urine]; Sleep Wake Disorders/pp [Physiopathology]; Tuberous Sclerosis/pp [Physiopathology]; sleep disturbance/disorders; trajectory; characteristics; melatonin
Creator
An entity primarily responsible for making the resource
Hancock E; O'Callaghan F; English J; Osborne J P
Description
An account of the resource
To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time). Total excretion, cosinor percentage, and acrophase time of 6-sulfatoxymelatonin excretion were estimated. In normal children, total 6-sulfatoxymelatonin excretion was range 11.1 to 40.2 microg (mean 19.0 microg, SD 7.4 microg); cosinor percentage rhythm range was 52.9% to 100% (mean 87%, median 94%); and acrophase time range was 23 hours, 54 minutes to 10 hours, 42 minutes (mean 5 hours, 54 minutes; median 4 hours, 12 minutes). Fifth and 95th percentiles were 11.1 to 29.0 microg, 57.8% to 99.9%, and 2 hours, 1 minute to 10 hours, 4 minutes. In tuberous sclerosis, normal patterns of melatonin excretion were seen in responders. Circadian patterns of melatonin excretion were similar in children and adults. We propose that exogenous melatonin can act by a simple sedative action.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/08830738050200010301" target="_blank" rel="noreferrer noopener">10.1177/08830738050200010301</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
0 (Antioxidants)
2005
2208-40-4 (6-sulfatoxymelatonin)
Administration Oral
Adolescent
Antioxidants
Antioxidants/ad [Administration & Dosage]
Antioxidants/pk [Pharmacokinetics]
Case-Control Studies
characteristics
Child
Child Preschool
Circadian Rhythm
English J
Female
Hancock E
Humans
JL5DK93RCL (Melatonin)
Journal of Child Neurology
Male
melatonin
Melatonin/aa [Analogs & Derivatives]
Melatonin/ad [Administration & Dosage]
Melatonin/pk [Pharmacokinetics]
Melatonin/ur [Urine]
O'Callaghan F
Osborne J P
Reference Values
sleep disturbance/disorders
Sleep Wake Disorders
Sleep Wake Disorders/co [Complications]
Sleep Wake Disorders/pp [Physiopathology]
Trajectory
Tuberous Sclerosis
Tuberous Sclerosis/co [Complications]
Tuberous Sclerosis/pp [Physiopathology]
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0387-7604(94)00118-h" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0387-7604(94)00118-h</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sleep disorders in tuberous sclerosis: a polysomnographic study
Publisher
An entity responsible for making the resource available
Brain and Development
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
Subject
The topic of the resource
Circadian Rhythm; Male; Child; Humans; Adolescent; Female; Child Preschool; Epilepsy; Tuberous Sclerosis; Polysomnography; Sleep Wake Disorders; sleep disturbance/disorders; trajectory; characteristics
Creator
An entity primarily responsible for making the resource
Bruni O; Cortesi F; Giannotti F; Curatolo P
Description
An account of the resource
Overnight polysomnography was performed in 10 subjects with tuberous sclerosis (TS) and partial epilepsy in order to investigate the relationships between sleep organization, sleep disorders and epilepsy. Sleep architecture abnormalities were observed in 9 cases. Compared with ten healthy age-matched controls, the TS group showed a shorter total sleep time, a reduced sleep efficiency, a higher number of awakenings and stage transitions, an increased wake after sleep onset and stage 1 and a decreased REM sleep. Children with seizures showed a more disrupted sleep architecture compared with seizure-free children. Sleep disorders in TS were mainly due to sleep-related epileptic events and were more evident in children who showed large bifrontal or temporal tubers on MRI.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0387-7604(94)00118-h" target="_blank" rel="noreferrer noopener">10.1016/0387-7604(94)00118-h</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Adolescent
Brain and Development
Bruni O
characteristics
Child
Child Preschool
Circadian Rhythm
Cortesi F
Curatolo P
Epilepsy
Female
Giannotti F
Humans
Male
Polysomnography
sleep disturbance/disorders
Sleep Wake Disorders
Trajectory
Tuberous Sclerosis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0003-9969(92)90076-k" target="_blank" rel="noreferrer">http://doi.org/10.1016/0003-9969(92)90076-k</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methionine enkephalin-like, substance P-like, and beta-endorphin-like immunoreactivity in human parotid saliva
Publisher
An entity responsible for making the resource available
Archives Of Oral Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
The topic of the resource
Female; Humans; Male; Adult; Middle Aged; Biomarkers of Pain; beta-Endorphin/analysis; Circadian Rhythm; Enkephalin; Methionine/analysis; Parotid Gland/secretion; Radioimmunoassay; Saliva/chemistry; Salivary Proteins/analysis; Substance P/analysis
Creator
An entity primarily responsible for making the resource
Pikula DL; Harris EF; Desiderio DM; Fridland GH; Lovelace JL
Description
An account of the resource
These three neuropeptides were measured at daily baseline values by radioimmunoassay. Stimulated parotid saliva was collected from 31 subjects using a modified Carlson-Crittenden device affixed over Stenson's duct. Methionine enkephalin-like immunoreactivity ranged from 6.6 to 11.7 fmol/ml, with a mean of 9.3 fmol/ml. Substance P-like immunoreactivity ranged from 6.1 to 12.6 fmol/ml, with a mean of 9.3 fmol/ml. beta-Endorphin-like immunoreactivity ranged from 1.2 to 3.6 fmol/ml, with a mean of 2.6 fmol/ml. This is believed to be the first documentation of methionine enkephalin- and substance P-like activities in human parotid saliva and the first demonstration of beta-endorphin-like activity in any type of human saliva. Substance P-like activity was significantly higher in morning than evening samples; beta-endorphin-like activity also tended to be higher in the morning samples. Substance P and beta-endorphin-like immunoreactivities covaried in a significant positive manner, suggesting either common control mechanisms or similar responses to physiological variables.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0003-9969(92)90076-k" target="_blank" rel="noreferrer">10.1016/0003-9969(92)90076-k</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
Adult
Archives Of Oral Biology
Backlog
beta-Endorphin/analysis
Biomarkers of Pain
Circadian Rhythm
Desiderio DM
Enkephalin
Female
Fridland GH
Harris EF
Humans
Journal Article
Lovelace JL
Male
Methionine/analysis
Middle Aged
Parotid Gland/secretion
Pikula DL
Radioimmunoassay
Saliva/chemistry
Salivary Proteins/analysis
Substance P/analysis