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Text
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URL Address
<a href="http://doi.org/10.1186/ar3306" target="_blank" rel="noreferrer">http://doi.org/10.1186/ar3306</a>
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Title
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The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia
Publisher
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Arthritis Research & Therapy
Date
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2011
Subject
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Humans; Animals; Arthritis; Central Nervous System/physiopathology; Chronic Pain/complications/physiopathology; Fibromyalgia/complications/physiopathology; Osteoarthritis/complications/physiopathology; Rheumatoid/complications/physiopathology
Creator
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Lee YC; Nassikas NJ; Clauw DJ
Description
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Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, alpha2delta ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids).
Identifier
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<a href="http://doi.org/10.1186/ar3306" target="_blank" rel="noreferrer">10.1186/ar3306</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2011
Animals
Arthritis
Arthritis Research & Therapy
Backlog
Central Nervous System/physiopathology
Chronic Pain/complications/physiopathology
Clauw DJ
Fibromyalgia/complications/physiopathology
Humans
Journal Article
Lee YC
Nassikas NJ
Osteoarthritis/complications/physiopathology
Rheumatoid/complications/physiopathology