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Text
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URL Address
<a href="http://doi.org/10.1016/j.ejpain.2004.05.009" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.ejpain.2004.05.009</a>
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Title
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Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia
Publisher
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European Journal Of Pain
Date
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2005
Subject
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Humans; Analgesia; Biomarkers of Pain; Receptors; Pain/physiopathology; Cytokines/physiology; Opioid/physiology; Chemokines/physiology; Opioid Peptides/physiology; Pain Threshold/physiology
Creator
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Rittner HL; Stein C
Description
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Tissue destruction is accompanied by an inflammatory reaction. The inflammatory reaction leads to activation of nociceptors and the sensation of pain. Several mediators are responsible for pain and hyperalgesia in inflammation including cytokines, chemokines, nerve growth factor as well as bradykinin, prostaglandins and ATP. Simulatenously however, analgesic mediators are secreted: opioid peptides, somatostatin, endocannabinoids and certain cytokines. Opioid peptides secreted from immune cells are so far the best studied peptides in peripheral inflammatory pain control. This system is hampered for example by anti-adhesion molecule treatment. Novel immunosuppressive drugs for treatment of autoimmune disease targetting cytokines, chemokines or adhesion molecules should therefore be evaluated for potential harmful effects on pain.
2005
Identifier
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<a href="http://doi.org/10.1016/j.ejpain.2004.05.009" target="_blank" rel="noreferrer">10.1016/j.ejpain.2004.05.009</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2005
Analgesia
Backlog
Biomarkers of Pain
Chemokines/physiology
Cytokines/physiology
European Journal Of Pain
Humans
Journal Article
Opioid Peptides/physiology
Opioid/physiology
Pain Threshold/physiology
Pain/physiopathology
Receptors
Rittner HL
Stein C