1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1152/ajpregu.00087.2008" target="_blank" rel="noreferrer">http://doi.org/10.1152/ajpregu.00087.2008</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Endotoxin has acute and chronic effects on the cerebral circulation of fetal sheep. Publisher An entity responsible for making the resource available American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource Female; Fetal Death; Pregnancy; Animals; Statistical; Data Interpretation; Cerebrovascular Circulation/de [Drug Effects]; Endotoxins/pd [Pharmacology]; Fetus/bs [Blood Supply]; Lipopolysaccharides/pd [Pharmacology]; Blood Pressure/ph [Physiology]; Cerebrospinal Fluid/me [Metabolism]; Cytokines/bi [Biosynthesis]; Endothelial Cells/ph [Physiology]; Endotoxins/bl [Blood]; Lipopolysaccharides/bl [Blood]; Nitrates/bl [Blood]; Nitrites/bl [Blood]; Oxygen Consumption/ph [Physiology]; Sheep; Tumor Necrosis Factor-alpha/bl [Blood]; Vasodilation/de [Drug Effects] Creator An entity primarily responsible for making the resource Feng Susan YS; Phillips DJ; Stockx EM; Yu Victor YH; Walker AM Description An account of the resource We studied the impact of endotoxemia on cerebral blood flow (CBF), cerebral vascular resistance (CVR), and cerebral oxygen transport (O(2) transport) in fetal sheep. We hypothesized that endotoxemia impairs CBF regulation and O(2) transport, exposing the brain to hypoxic-ischemic injury. Responses to lipopolysaccharide (LPS; 1 microg/kg iv on 3 consecutive days, n = 9) or normal saline (n = 5) were studied. Of LPS-treated fetuses, five survived and four died; in surviving fetuses, transient cerebral vasoconstriction at 0.5 h (DeltaCVR approximately +50%) was followed by vasodilatation maximal at 5-6 h (DeltaCVR approximately -50%) when CBF had increased (approximately +60%) despite reduced ABP (approximately -20%). Decreased CVR and increased CBF persisted 24 h post-LPS and the two subsequent LPS infusions. Cerebral O(2) transport was sustained, although arterial O(2) saturation was reduced (P < 0.05). Histological evidence of neuronal injury was found in all surviving LPS-treated fetuses; one experienced grade IV intracranial hemorrhage. Bradykinin-induced cerebral vasodilatation (DeltaCVR approximately -20%, P < 0.05) was abolished after LPS. Fetuses that died post-LPS (n = 4) differed from survivors in three respects: CVR did not fall, CBF did not rise, and O(2) transport fell progressively. In conclusion, endotoxin disrupts the cerebral circulation in two phases: 1) acute vasoconstriction (1 h) and 2) prolonged vasodilatation despite impaired endothelial dilatation (24 h). In surviving fetuses, LPS causes brain injury despite cerebral O(2) transport being maintained by elevated cerebral perfusion; thus sustained O(2) transport does not prevent brain injury in endotoxemia. In contrast, cerebral hypoperfusion and reduced O(2) transport occur in fetuses destined to die, emphasizing the importance of sustaining O(2) transport for survival. 2009 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1152/ajpregu.00087.2008" target="_blank" rel="noreferrer">10.1152/ajpregu.00087.2008</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2009 American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology Animals Backlog Blood Pressure/ph [Physiology] Cerebrospinal Fluid/me [Metabolism] Cerebrovascular Circulation/de [Drug Effects] Cytokines/bi [Biosynthesis] Data Interpretation Endothelial Cells/ph [Physiology] Endotoxins/bl [Blood] Endotoxins/pd [Pharmacology] Female Feng Susan YS Fetal Death Fetus/bs [Blood Supply] Journal Article Lipopolysaccharides/bl [Blood] Lipopolysaccharides/pd [Pharmacology] Nitrates/bl [Blood] Nitrites/bl [Blood] Oxygen Consumption/ph [Physiology] Phillips DJ Pregnancy Sheep statistical Stockx EM Tumor Necrosis Factor-alpha/bl [Blood] Vasodilation/de [Drug Effects] Walker AM Yu Victor YH