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Text
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<a href="http://doi.org/10.1001/archpsyc.61.1.34" target="_blank" rel="noreferrer">http://doi.org/10.1001/archpsyc.61.1.34</a>
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Title
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Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy
Publisher
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Archives Of General Psychiatry
Date
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2004
Subject
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Female; Humans; Male; Adult; Follow-Up Studies; Middle Aged; Sensitivity and Specificity; Personality Inventory; Antidepressive Agents; Depressive Disorder; Ambulatory Care; Outcome and Process Assessment (Health Care); Non-U.S. Gov't; Research Support; Comparative Study; Blood Glucose/metabolism; Brain Mapping; Cerebral Cortex/physiopathology/radionuclide imaging; Cognitive Therapy; Emission-Computed; Energy Metabolism/physiology; Fluorodeoxyglucose F18/diagnostic use; Frontal Lobe/physiopathology/radionuclide imaging; Limbic System/physiopathology/radionuclide imaging; Major/physiopathology/radionuclide imaging/therapy; Nerve Net/physiopathology/radionuclide imaging; Neural Pathways/physiopathology/radionuclide imaging; Paroxetine/therapeutic use; Prefrontal Cortex/physiopathology/radionuclide imaging; Second-Generation/therapeutic use; Tomography
Creator
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Goldapple K; Segal Z; Garson C; Lau M; Bieling P; Kennedy S; Mayberg H
Description
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BACKGROUND: Functional imaging studies of major depressive disorder demonstrate response-specific regional changes following various modes of antidepressant treatment. OBJECTIVE: To examine changes associated with cognitive behavior therapy (CBT). METHODS: Brain changes underlying response to CBT were examined using resting-state fluorine-18-labeled deoxyglucose positron emission tomography. Seventeen unmedicated, unipolar depressed outpatients (mean +/- SD age, 41 +/- 9 years; mean +/- SD initial 17-item Hamilton Depression Rating Scale score, 20 +/- 3) were scanned before and after a 15- to 20-session course of outpatient CBT. Whole-brain, voxel-based methods were used to assess response-specific CBT effects. A post hoc comparison to an independent group of 13 paroxetine-treated responders was also performed to interpret the specificity of identified CBT effects. RESULTS: A full course of CBT resulted in significant clinical improvement in the 14 study completers (mean +/- SD posttreatment Hamilton Depression Rating Scale score of 6.7 +/- 4). Treatment response was associated with significant metabolic changes: increases in hippocampus and dorsal cingulate (Brodmann area [BA] 24) and decreases in dorsal (BA 9/46), ventral (BA 47/11), and medial (BA 9/10/11) frontal cortex. This pattern is distinct from that seen with paroxetine-facilitated clinical recovery where prefrontal increases and hippocampal and subgenual cingulate decreases were seen. CONCLUSIONS: Like other antidepressant treatments, CBT seems to affect clinical recovery by modulating the functioning of specific sites in limbic and cortical regions. Unique directional changes in frontal cortex, cingulate, and hippocampus with CBT relative to paroxetine may reflect modality-specific effects with implications for understanding mechanisms underlying different treatment strategies.
2004
Identifier
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<a href="http://doi.org/10.1001/archpsyc.61.1.34" target="_blank" rel="noreferrer">10.1001/archpsyc.61.1.34</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2004
Adult
Ambulatory Care
Antidepressive Agents
Archives Of General Psychiatry
Backlog
Bieling P
Blood Glucose/metabolism
Brain Mapping
Cerebral Cortex/physiopathology/radionuclide imaging
Cognitive Therapy
Comparative Study
Depressive Disorder
Emission-Computed
Energy Metabolism/physiology
Female
Fluorodeoxyglucose F18/diagnostic use
Follow-up Studies
Frontal Lobe/physiopathology/radionuclide imaging
Garson C
Goldapple K
Humans
Journal Article
Kennedy S
Lau M
Limbic System/physiopathology/radionuclide imaging
Major/physiopathology/radionuclide imaging/therapy
Male
Mayberg H
Middle Aged
Nerve Net/physiopathology/radionuclide imaging
Neural Pathways/physiopathology/radionuclide imaging
Non-U.S. Gov't
Outcome And Process Assessment (health Care)
Paroxetine/therapeutic use
Personality Inventory
Prefrontal Cortex/physiopathology/radionuclide imaging
Research Support
Second-Generation/therapeutic use
Segal Z
Sensitivity and Specificity
Tomography