1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1152/jappl.2000.89.4.1561" target="_blank" rel="noreferrer">http://doi.org/10.1152/jappl.2000.89.4.1561</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Systemic hypoxia increases leukocyte emigration and vascular permeability in conscious rats.
Publisher
An entity responsible for making the resource available
Journal Of Applied Physiology (bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Male; Animals; Rats; Sprague-Dawley; Endothelium; Vascular/ph [Physiology]; Anoxia/pp [Physiopathology]; Capillary Permeability/ph [Physiology]; Endothelium; Leukocytes/ph [Physiology]; Venules/ph [Physiology]; Antioxidants/pd [Pharmacology]; Capillary Permeability/de [Drug Effects]; Catalase/pd [Pharmacology]; Cell Adhesion; Consciousness; Leukocytes/de [Drug Effects]; Nitric Oxide Donors/pd [Pharmacology]; Nitrogen Oxides; Reactive Oxygen Species/ph [Physiology]; Spermine/aa [Analogs & Derivatives]; Spermine/pd [Pharmacology]; Splanchnic Circulation/ph [Physiology]; Superoxide Dismutase/pd [Pharmacology]; Vascular/pp [Physiopathology]; Venules/pp [Physiopathology]
Creator
An entity primarily responsible for making the resource
Wood JG; Johnson JS; Mattioli LF; Gonzalez NC
Description
An account of the resource
We recently observed that acute systemic hypoxia produces rapid increases in leukocyte adherence in the mesenteric microcirculation of the anesthetized rat Wood JG, Johnson JS, Mattioli LF, and Gonzalez NC. J Appl Physiol 87: 1734-1740, 1999; Wood JG, Mattioli LF, and Gonzalez NC. J Appl Physiol 87: 873-881, 1999. Hypoxia-induced leukocyte adherence is associated with an increase in reactive oxygen species (ROS) generation and is attenuated by antioxidants or interventions that increase tissue levels of nitric oxide (NO). These results suggest that the acute effects of hypoxia on leukocyte-endothelial interactions are caused by a change in the ROS-NO balance. The present experiments were designed to extend our observations of the initial microcirculatory response to hypoxia; specifically, we wanted to determine whether the response to systemic hypoxia involves increased microvascular permeability and leukocyte emigration and whether ROS generation and decreased NO levels contribute to these responses. At this time, there is conflicting evidence, from in vitro studies, regarding the effect of hypoxia on these indexes of vascular function. Our studies were carried out in the physiological setting of the conscious animal, in which a prolonged hypoxic exposure is possible without the adverse effects that may develop under anesthesia. The central observation of these studies is that conscious animals exposed for 4 h to environmental hypoxia show increased microvascular permeability and emigration of leukocytes into the extravascular space of the mesenteric circulation. Furthermore, these events are dependent on increased ROS generation and, possibly, a subsequent decrease in tissue NO levels during systemic hypoxia. Our results show that systemic hypoxia profoundly affects vascular endothelial function through changes in the ROS-NO balance in the conscious animal.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.2000.89.4.1561" target="_blank" rel="noreferrer">10.1152/jappl.2000.89.4.1561</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Animals
Anoxia/pp [Physiopathology]
Antioxidants/pd [Pharmacology]
Backlog
Capillary Permeability/de [Drug Effects]
Capillary Permeability/ph [Physiology]
Catalase/pd [Pharmacology]
Cell Adhesion
Consciousness
Endothelium
Gonzalez NC
Johnson JS
Journal Article
Journal Of Applied Physiology (bethesda, Md. : 1985)
Leukocytes/de [Drug Effects]
Leukocytes/ph [Physiology]
Male
Mattioli LF
Nitric Oxide Donors/pd [Pharmacology]
Nitrogen Oxides
Rats
Reactive Oxygen Species/ph [Physiology]
Spermine/aa [Analogs & Derivatives]
Spermine/pd [Pharmacology]
Splanchnic Circulation/ph [Physiology]
Sprague-Dawley
Superoxide Dismutase/pd [Pharmacology]
Vascular/ph [Physiology]
Vascular/pp [Physiopathology]
Venules/ph [Physiology]
Venules/pp [Physiopathology]
Wood JG