1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1097/01.ijg.0000212260.04488.60" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.ijg.0000212260.04488.60</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study Publisher An entity responsible for making the resource available Journal Of Glaucoma Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Humans; Male; Middle Aged; Pilot Projects; Double-Blind Method; Cross-Over Studies; Administration; Sublingual; Cannabidiol/administration & dosage; Glaucoma; Intraocular Pressure/drug effects; Ocular Hypertension/drug therapy; Open-Angle/drug therapy; Psychotropic Drugs/administration & dosage; Tetrahydrocannabinol/administration & dosage; Visual Acuity/drug effects Creator An entity primarily responsible for making the resource Tomida I; Azuara-Blanco A; House H; Flint M; Pertwee RG; Robson PJ Description An account of the resource PURPOSE: The purpose of this study was to assess the effect on intraocular pressure (IOP) and the safety and tolerability of oromucosal administration of a low dose of delta-9-tetrahydrocannabinol (Delta-9-THC) and cannabidiol (CBD). PATIENTS AND METHODS: A randomized, double-masked, placebo-controlled, 4 way crossover study was conducted at a single center, using cannabis-based medicinal extract of Delta-9-THC and CBD. Six patients with ocular hypertension or early primary open angle glaucoma received a single sublingual dose at 8 AM of 5 mg Delta-9-THC, 20 mg CBD, 40 mg CBD, or placebo. Main outcome measure was IOP. Secondary outcomes included visual acuity, vital signs, and psychotropic effects. RESULTS: Two hours after sublingual administration of 5 mg Delta-9-THC, the IOP was significantly lower than after placebo (23.5 mm Hg vs. 27.3 mm Hg, P=0.026). The IOP returned to baseline level after the 4-hour IOP measurement. CBD administration did not reduce the IOP at any time. However, the higher dose of CBD (40 mg) produced a transient elevation of IOP at 4 hours after administration, from 23.2 to 25.9 mm Hg (P=0.028). Vital signs and visual acuity were not significantly changed. One patient experienced a transient and mild paniclike reaction after Delta-9-THC administration. CONCLUSIONS: A single 5 mg sublingual dose of Delta-9-THC reduced the IOP temporarily and was well tolerated by most patients. Sublingual administration of 20 mg CBD did not reduce IOP, whereas 40 mg CBD produced a transient increase IOP rise. 2006 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/01.ijg.0000212260.04488.60" target="_blank" rel="noreferrer">10.1097/01.ijg.0000212260.04488.60</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Administration Azuara-Blanco A Backlog Cannabidiol/administration & dosage Cross-Over Studies Double-Blind Method Flint M Glaucoma House H Humans Intraocular Pressure/drug effects Journal Article Journal Of Glaucoma Male Middle Aged Ocular Hypertension/drug therapy Open-Angle/drug therapy Pertwee RG Pilot Projects Psychotropic Drugs/administration & dosage Robson PJ Sublingual Tetrahydrocannabinol/administration & dosage Tomida I Visual Acuity/drug effects