1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1042/bse0390105" target="_blank" rel="noreferrer">http://doi.org/10.1042/bse0390105</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The final step in programmed cell death: phagocytes carry apoptotic cells to the grave.
Publisher
An entity responsible for making the resource available
Essays In Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Animals; Models; Receptors; Signal Transduction; Molecular; Inflammation/metabolism; Apoptosis; Phagocytosis; Biological; Caenorhabditis elegans/genetics; Cell Surface/me [Metabolism]; Drosophila melanogaster/genetics; Evolution; Mice/genetics; Phagocytes/physiology
Creator
An entity primarily responsible for making the resource
deCathelineau AM; Henson PM
Description
An account of the resource
As cells undergo apoptosis, they are recognized and removed from the body by phagocytes. This oft-overlooked yet critical final step in the cell-death programme protects tissues from exposure to the toxic contents of dying cells and also serves to prevent further tissue damage by stimulating production of anti-inflammatory cytokines and chemokines. The clearance of apoptotic-cell corpses occurs throughout the lifespan of multicellular organisms and is important for normal development during embryogenesis, the maintenance of normal tissue integrity and function, and the resolution of inflammation. Many of the signal-transduction molecules implicated in the phagocytosis of apoptotic cells appear to have a high degree of evolutionary conservation, and therefore the engulfment of apoptotic cells is likely to represent one of the most primitive forms of phagocytosis. With the realization that the signals that govern apoptotic-cell removal also serve to attenuate inflammation and the immune response, as well as initiate signals for tissue repair and remodelling in response to cell death, the study of apoptotic cell clearance is a field experiencing a dynamic increase in interest and momentum.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1042/bse0390105" target="_blank" rel="noreferrer">10.1042/bse0390105</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Animals
Apoptosis
Backlog
Biological
Caenorhabditis elegans/genetics
Cell Surface/me [Metabolism]
deCathelineau AM
Drosophila melanogaster/genetics
Essays In Biochemistry
Evolution
Henson PM
Inflammation/metabolism
Journal Article
Mice/genetics
Models
Molecular
Phagocytes/physiology
Phagocytosis
Receptors
Signal Transduction