1
40
16
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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2022 Special Edition 3 - Oncology List
Text
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Citation List Month
2022 Special Edition 3 - Oncology List
URL Address
<a href="http://doi.org/10.3390/children9020274" target="_blank" rel="noreferrer noopener"> http://doi.org/10.3390/children9020274</a>
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Title
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Bereaved Parent Perspectives on End-of-Life Conversations in Pediatric Oncology
Publisher
An entity responsible for making the resource available
Children (Basel)
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Creator
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Robert R; Razvi S; Triche LL; Bruera E; Moody KM
Description
An account of the resource
BACKGROUND: Professional education pertaining to end-of-life care with pediatric oncology patients is limited. Pediatric trainees learn about end-of-life conversations largely from the provider's perspective. Bereaved parents can inform the education of oncologists and the interdisciplinary team by sharing their perceptions and preferences through personal narratives. METHODS: The aim of this project was to enhance the healthcare teams' understanding of bereaved parents' end-of-life care preferences through narratives. Bereaved parents were recruited from our institution's Pediatric Supportive Care Committee membership. Parents were tasked with identifying elements of care that were of the greatest importance to them, based upon their personal experiences during their child's end-of-life care. Narratives were analyzed using standard qualitative methods. RESULTS: Parents of five patients participated, including four mothers and three fathers. Ten themes summarizing essential elements of end-of-life care were identified, including early ongoing and stepwise prognostic disclosure, honoring the child's voice, support of hope and realism, anticipatory guidance on dying, and continued contact with the bereaved. CONCLUSION: Bereaved parents emphasize the need for providers to have ongoing honest conversations that support realism and hope that can help them to best prepare for their child's end of life and to remain in contact with them after death.
Identifier
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<a href="http://doi.org/10.3390/children9020274" target="_blank" rel="noreferrer noopener">10.3390/children9020274</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2022
2022 Special Edition 3 - Oncology List
Bruera E
Cancer
Caregiver experience
Child
Children (Basel)
End Of Life
Moody KM
Palliative Care
Patient experience
Pediatrics
Razvi S
Robert R
Triche LL
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/cncr.25045" target="_blank" rel="noreferrer">http://doi.org/10.1002/cncr.25045</a>
Dublin Core
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Title
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Characteristics of patients who refuse do-not-resuscitate orders upon admission to an acute palliative care unit in a comprehensive cancer center.
Publisher
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Cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Female; Humans; Male; Palliative Care; Adult; Middle Aged; Patient Acceptance of Health Care; Survival Analysis; Case-Control Studies; African Americans; retrospective studies; DNAR; Cancer Care Facilities; Neoplasms/di [Diagnosis]; Neoplasms/mo [Mortality]; Resuscitation Orders; Nausea/co [Complications]; Pain/co [Complications]
Creator
An entity primarily responsible for making the resource
Parsons HA; de la Cruz MJ; Zhukovsky DS; Hui D; Delgado-Guay MO; Akitoye AE; El Osta B; Palmer JL; Palla SL; Bruera E
Description
An account of the resource
BACKGROUND: Refusal of appropriately indicated do-not-resuscitate (DNR) orders may cause harm and distress for patients, families, and the medical team. We conducted a retrospective study to determine the frequency and predictors of refusals of DNR in advanced cancer patients admitted to an acute palliative care unit., METHODS: A total of 2538 consecutive admissions were reviewed. Demographic and clinical characteristics from 200 consecutive patients with DNR orders and 100 consecutive patients who refused DNR were collected, and differences between the groups were determined by multivariate regression and recursive partitioning analysis., RESULTS: Of 2538 admissions, 2530 (99%) were appropriate for DNR discussion. Of the 2530 admissions, 2374 were unique patients, and 100 (4%) of 2374 refused DNR. Refusers had median (interquartile range, IQR) pain of 7 (4-9) versus 5 (3-8, P = .0005), nausea of 2 (0-7) versus 1 (0-4, P = .05), and dyspnea of 1 (0-5) versus 4 (0-7, P = .002) as compared with DNR nonrefusers, respectively. Patients with hematological malignancies and advance directives had a lower DNR refusal risk (odds ratio [OR], 0.38; P = .02, and OR, 0.36; P < .0001, respectively). Multivariate regression analysis revealed that patients with moderate-severe pain (OR, 3.19; P = .002) and with no advance directives (OR, 2.94; P < or = .001) had higher DNR refusal risk. There were more inpatient deaths among DNR nonrefusers (87 of 200 vs 1 of 100, P < .0001). Median (IQR) time from discharge to death was 18 (8-35) days for those with DNR orders and 85 (25-206) days for DNR refusers (P < or = .0001)., CONCLUSIONS: DNR refusal in patients admitted to the acute palliative care unit is low, more frequent in patients with more pain and nausea and no advance directives, and associated with longer survival. This study demonstrates possible predictors of complicated DNR discussions.
2010
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/cncr.25045" target="_blank" rel="noreferrer">10.1002/cncr.25045</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2010
Adult
African Americans
Akitoye AE
Backlog
Bruera E
Cancer
Cancer Care Facilities
Case-Control Studies
de la Cruz MJ
Delgado-Guay MO
DNAR
El Osta B
Female
Hui D
Humans
Journal Article
Male
Middle Aged
Nausea/co [Complications]
Neoplasms/di [Diagnosis]
Neoplasms/mo [mortality]
Pain/co [Complications]
Palla SL
Palliative Care
Palmer JL
Parsons HA
Patient Acceptance of Health Care
Resuscitation Orders
Retrospective Studies
Survival Analysis
Zhukovsky DS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1089/jpm.2008.0152" target="_blank" rel="noreferrer">http://doi.org/10.1089/jpm.2008.0152</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The impact of palliative care consultation on symptom assessment, communication needs, and palliative interventions in pediatric patients with cancer
Publisher
An entity responsible for making the resource available
Journal Of Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
Creator
An entity primarily responsible for making the resource
Zhukovsky DS; Herzog CE; Kaur G; Palmer JL; Bruera E
Identifier
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<a href="http://doi.org/10.1089/jpm.2008.0152" target="_blank" rel="noreferrer">10.1089/jpm.2008.0152</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2009
2009
Backlog
Bruera E
Herzog CE
Journal Article
Journal of Palliative Medicine
Kaur G
Palmer JL
Zhukovsky DS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1089/jpm.2009.0376" target="_blank" rel="noreferrer">http://doi.org/10.1089/jpm.2009.0376</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Advance directives and do-not-resuscitate orders in patients with cancer with metastatic spinal cord compression: advanced care planning implications.
Publisher
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Journal Of Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Female; Humans; Male; United States; Young Adult; Physician-Patient Relations; Adult; Aged; Middle Aged; Communication; 80 and over; DNAR; Palliative Care/lj [Legislation & Jurisprudence]; Advance Directives/lj [Legislation & Jurisprudence]; Health Planning/lj [Legislation & Jurisprudence]; Neoplasms/pa [Pathology]; Resuscitation Orders/lj [Legislation & Jurisprudence]; Spinal Cord Compression/et [Etiology]; Spinal Cord Compression/pa [Pathology]; Spinal Neoplasms/co [Complications]; Spinal Neoplasms/sc [Secondary]; Palliative Care/ut [Utilization]
Creator
An entity primarily responsible for making the resource
Guo Y; Palmer JL; Bianty J; Konzen B; Shin Ki; Bruera E
Description
An account of the resource
OBJECTIVES: Communication about end-of-life decisions is crucial. Although patients with metastatic spinal cord compression (MSCC) have a median survival time of 3 to 6 months, few data are available concerning the presence of advance directives and do-not-resuscitate (DNR) orders in this population. The objective of this study was to determine presence of advance directives and DNR order among patients with MSCC., METHODS: We retrospectively reviewed data concerning advance directives for 88 consecutive patients with cancer who had MSCC and required rehabilitation consultation at The University of Texas M. D. Anderson Cancer Center from September 20, 2005 to August 29, 2008. We characterized the data using univariate descriptive statistics and used the Fisher exact test to find correlations., RESULTS: The mean age of this patient population was 55 years (range, 24-81). Thirty patients (33%) were female. Twenty patients (23%) had a living will, 27 patients (31%) had health care proxies, and 10 patients (11%) had either out-of-hospital DNR order and/or dictated DNR note. The median survival time for these patients was 4.3 months., CONCLUSION: Despite strong evidence showing short survival times for MSCC patients, it seems many of these patients are not aware of the urgency to have an advance directive. This may be an indicator of delayed end-of-life palliative care and suboptimal doctor-patient communication. Using the catastrophic event of a diagnosis of MSCC to trigger communication and initiate palliative care may be beneficial to patients and their families.
2010
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/jpm.2009.0376" target="_blank" rel="noreferrer">10.1089/jpm.2009.0376</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2010
80 And Over
Adult
Advance Directives/lj [Legislation & Jurisprudence]
Aged
Backlog
Bianty J
Bruera E
Communication
DNAR
Female
Guo Y
Health Planning/lj [Legislation & Jurisprudence]
Humans
Journal Article
Journal of Palliative Medicine
Konzen B
Male
Middle Aged
Neoplasms/pa [Pathology]
Palliative Care/lj [Legislation & Jurisprudence]
Palliative Care/ut [Utilization]
Palmer JL
Physician-patient Relations
Resuscitation Orders/lj [Legislation & Jurisprudence]
Shin Ki
Spinal Cord Compression/et [Etiology]
Spinal Cord Compression/pa [Pathology]
Spinal Neoplasms/co [Complications]
Spinal Neoplasms/sc [Secondary]
United States
Young Adult
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1089/10966210252785097" target="_blank" rel="noreferrer">http://doi.org/10.1089/10966210252785097</a>
Dublin Core
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Title
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Methadone use in cancer patients with pain: a review
Publisher
An entity responsible for making the resource available
Journal Of Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Analgesics; Drug Interactions; Pain/drug therapy/etiology; Neoplasms/complications; Methadone/pharmacokinetics/therapeutic use; Opioid/pharmacokinetics/therapeutic use
Creator
An entity primarily responsible for making the resource
Bruera E; Sweeney C
Description
An account of the resource
In recent years a better understanding of the pharmacologic and pharmacokinetic properties of methadone, including equianalgesic ratios has led to its increased use as a second line opioid for the treatment of pain in patients with cancer. Methadone may be an important alternative for those who have side effects related to the use of other opioids because it has no known active metabolites, is well absorbed by oral and rectal routes, and also has the advantage of very low cost. However, it has a long, unpredictable half-life, which can result in accumulation and toxicity in some patients. In addition, rotation to methadone as a second line agent is more complex than with other opioids because of its increased potency in those patients who are opioid tolerant, particularly those who have been on higher doses of other opioids. Future research should address the use of methadone as a first-line agent in the management of cancer pain, its use in patients with neuropathic pain, and in those who develop rapid tolerance to other opioids. In some patients with cancer the long half-life of methadone offers the advantage of extended dosing intervals to 12 and even 24 hours, further research is also needed in this area.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/10966210252785097" target="_blank" rel="noreferrer">10.1089/10966210252785097</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Analgesics
Backlog
Bruera E
Drug Interactions
Humans
Journal Article
Journal of Palliative Medicine
Methadone/pharmacokinetics/therapeutic use
Neoplasms/complications
Opioid/pharmacokinetics/therapeutic use
Pain/drug therapy/etiology
Sweeney C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/(SICI)1097-0142(19960815)78:4%3C852::AID-CNCR23%3E3.0.CO" target="_blank" rel="noreferrer">http://doi.org/10.1002/(SICI)1097-0142(19960815)78:4%3C852::AID-CNCR23%3E3.0.CO</a>
Dublin Core
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Title
A name given to the resource
Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine
Publisher
An entity responsible for making the resource available
Cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
Subject
The topic of the resource
Female; Humans; Male; Cohort Studies; Analgesics; Aged; Middle Aged; Drug Administration Schedule; 80 and over; Comparative Study; Administration; Oral; Pain/drug therapy/etiology; retrospective studies; Injections; Dose-Response Relationship; Drug; Hydromorphone/adverse effects/therapeutic use; Methadone/adverse effects/therapeutic use; Morphine/adverse effects/therapeutic use; Neoplasms/complications; Opioid/adverse effects/therapeutic use; Subcutaneous
Creator
An entity primarily responsible for making the resource
Bruera E; Pereira J; Watanabe S; Belzile M; Kuehn N; Hanson J
Identifier
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<a href="http://doi.org/10.1002/(SICI)1097-0142(19960815)78:4%3C852::AID-CNCR23%3E3.0.CO" target="_blank" rel="noreferrer">10.1002/(SICI)1097-0142(19960815)78:4%3C852::AID-CNCR23%3E3.0.CO</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
BACKGROUND. When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:1 between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose ratios ranging from 1:6 to 1:10 are proposed. The purpose of this study was to review the analgesic dose ratios for methadone compared with hydromorphone. METHODS. In a retrospective study, 48 cases of medication changes from morphine to hydromorphone, and 65 changes between hydromorphone and methadone were identified. the reason for the change, the analgesic dose, and pain intensity were obtained. RESULTS. The dose ratios between morphine and hydromorphone and vice versa were found to be 5.33 and 0.28, respectively (similar to expected results). However, the hydromorphone/methadone ratio was found to be 1.14:1 (5 to 10 times higher than expected). Although the dose ratios of hydromorphone/morphine and vice versa did not change according to a previous opioid dose, the hydromorphone/methadone ratio correlated with total opioid dose (correlation coefficient = 0.41 P < 0.001) and was 1.6 (range, 0.3-14.4) in patients receiving more than 330 mg of hydromorphone per day prior to the change, versus 0.95 (range, 0.2-12.3) in patients receiving ae330 mg of hydromorphone per day (P = 0.023). CONCLUSIONS. These results suggest that only partial tolerance develops between methadone and hydromorphone. Methadone is much more potent than previously described and any change should start at a lower equivalent dose.
1996
80 And Over
Administration
Aged
Analgesics
Backlog
Belzile M
Bruera E
Cancer
Cohort Studies
Comparative Study
Dose-Response Relationship
Drug
Drug Administration Schedule
Female
Hanson J
Humans
Hydromorphone/adverse effects/therapeutic use
Injections
Journal Article
Kuehn N
Male
Methadone/adverse effects/therapeutic use
Middle Aged
Morphine/adverse effects/therapeutic use
Neoplasms/complications
Opioid/adverse effects/therapeutic use
Oral
Pain/drug therapy/etiology
Pereira J
Retrospective Studies
Subcutaneous
Watanabe S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0885-3924(92)90101-m" target="_blank" rel="noreferrer">http://doi.org/10.1016/0885-3924(92)90101-m</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A double-blind, crossover trial of intravenous clodronate in metastatic bone pain
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
The topic of the resource
Female; Humans; Male; Pain Measurement; Adult; Aged; Middle Aged; Double-Blind Method; 80 and over; Infusions; Intravenous; Clodronate; Clodronic Acid/administration & dosage/therapeutic use; Bone Neoplasms/physiopathology/secondary; Pain/diagnosis/drug therapy/etiology
Creator
An entity primarily responsible for making the resource
Ernst DS; MacDonald RN; Paterson AH; Jensen J; Brasher P; Bruera E
Description
An account of the resource
After a baseline symptom and laboratory assessment, 24 patients with metastatic bone disease and pain were randomized to receive either a 4-hr intravenous infusion of 2-dichloromethylene bisphosphonate (Cl2MDP), 600 mg in 500 mL of normal saline, or a 4-hr placebo infusion, 500 mL of normal saline. The administration was double blind. After 1 wk, the assessment was repeated and the patients were crossed over to the alternate treatment. After 1 more wk, a final assessment and blinded choice by the patient and investigator took place. Of the 21 evaluable patients, 12 (57%) chose the Cl2MDP and 4 (19%) chose the placebo; 5 (24%) patients did not have a specific preference (p = NS). The investigator chose the Cl2MDP in 14 (67%) cases, placebo in 6 (29%) cases and was unable to discern a difference in 1 (5%) case (p less than 0.05). The patients and investigator made similar selections in 16 (76%) instances. On the visual analogue scale assessments, a significant decrease in pain scores was observed following the Cl2MDP infusion (p less than 0.01) and an increase in activity scores was also demonstrated (p less than 0.01). No significant difference in the daily oral morphine equivalent analgesic requirement was demonstrated for either arm. No difference in clinical and laboratory parameters of toxicity was evident between the placebo and Cl2MDP arms of the trial. Our preliminary findings suggest that Cl2MDP is safe, and has analgesic properties that may prove to be useful in the management of metastatic bone pain.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0885-3924(92)90101-m" target="_blank" rel="noreferrer">10.1016/0885-3924(92)90101-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
80 And Over
Adult
Aged
Backlog
Bone Neoplasms/physiopathology/secondary
Brasher P
Bruera E
Clodronate
Clodronic Acid/administration & dosage/therapeutic use
Double-Blind Method
Ernst DS
Female
Humans
Infusions
Intravenous
Jensen J
Journal Article
Journal of Pain and Symptom Management
MacDonald RN
Male
Middle Aged
Pain Measurement
Pain/diagnosis/drug therapy/etiology
Paterson AH
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0140-6736(05)64524-2" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0140-6736(05)64524-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Subcutaneous clodronate
Publisher
An entity responsible for making the resource available
Lancet
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
Subject
The topic of the resource
Humans; Male; Analgesics; Aged; Middle Aged; Infusions; Parenteral; Hypercalcemia/drug therapy; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage
Creator
An entity primarily responsible for making the resource
Walker P; Watanabe S; Lawlor P; Bruera E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0140-6736(05)64524-2" target="_blank" rel="noreferrer">10.1016/s0140-6736(05)64524-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1996
1996
Aged
Analgesics
Backlog
Bruera E
Clodronic Acid/administration & dosage
Humans
Hypercalcemia/drug therapy
Infusions
Journal Article
Lancet
Lawlor P
Male
Middle Aged
Non-Narcotic/administration & dosage
Parenteral
Walker P
Watanabe S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0304-3959(96)03286-1" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0304-3959(96)03286-1</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An update on the clinical use of methadone for cancer pain
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Humans; Analgesics; Non-U.S. Gov't; Research Support; Evaluation Studies; Administration; Oral; Neoplasms/drug therapy; Methadone/administration & dosage/adverse effects/therapeutic use; Opioid/administration & dosage/adverse effects/therapeutic use; Rectal; Palliative Care/trends
Creator
An entity primarily responsible for making the resource
Ripamonti C; Zecca E; Bruera E
Description
An account of the resource
Methadone is a synthetic opioid agonist considered a second choice drug in the management of cancer pain. Methadone has a number of unique characteristics including excellent oral and rectal absorption, no known active metabolites, high potency, low cost, and longer administration intervals, as well as an incomplete cross-tolerance with respect to other mu-opioid receptor agonist drugs. For these reasons, methadone has the potential of playing a major role in the treatment of cancer pain. However, its use is limited by the remarkably long and unpredictable half-life, large inter-individual variations in pharmacokinetics, the potential for delayed toxicity, and above all by the limited knowledge of correct administration intervals and the equianalgesic ratio with other opioids when administered chronically. Recent findings suggest that standard equianalgesic tables are unreliable for methadone titration in patients tolerant to high doses of opioid agonists and that switchovers should take place slowly and should be personalized. Future research has to better define the variation in both bioavailability and elimination of methadone in different patient populations, the interaction between methadone and the most commonly used drugs in cancer patients, the type and activity of potential methadone metabolites, and the equianalgesic doses between methadone and the most commonly used opioids.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3959(96)03286-1" target="_blank" rel="noreferrer">10.1016/s0304-3959(96)03286-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
Administration
Analgesics
Backlog
Bruera E
Evaluation Studies
Humans
Journal Article
Methadone/administration & dosage/adverse effects/therapeutic use
Neoplasms/drug therapy
Non-U.S. Gov't
Opioid/administration & dosage/adverse effects/therapeutic use
Oral
Pain
Palliative Care/trends
Rectal
Research Support
Ripamonti C
Zecca E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(00)00212-8" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(00)00212-8</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
How children die in hospital.
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Child; Humans; Death; Palliative Care; symptoms; Euthanasia; Communication; Death; Resuscitation Orders; Longitudinal Studies; Critical Care; Children; Children; Preschool; infant; DNAR; Human; Pediatric intensive care unit; Passive; Hospital Mortality; Infant Mortality; Canuck Place 15 year chart review; dying; Infants; Pediatric intensive care unit
Creator
An entity primarily responsible for making the resource
McCallum DE; Byrne P; Bruera E
Description
An account of the resource
A retrospective analysis was performed to describe the course of terminal care provided to dying hospitalized children in terms of symptom assessment and management, and communication and decision-making, at the end of life. Seventy-seven of 236 infants and children who died after hospital admission in Edmonton, Canada between January 1996 and June 1998 met entry criteria. Only children who died after a minimum hospitalization of 24 hours in the case of chronic illness or after a minimum hospitalization of 7 days following an acute event were included. Unanticipated deaths were excluded. Eighty-three percent of children died in intensive care settings (64/77), and 78 % (60/77) were intubated prior to their death. Symptoms were recorded in narrative progress notes. Five of 77 (6%) charts contained specific pain assessment and treatment records. Opioid analgesia was provided in 84 % of all cases (65/77). Six (8 %) patients had do not resuscitate (DNNR) orders preceding final hospital admission and 56/71 (79%) remaining patients had documented discussion resulting in DNR decision during final hospital admission. Median time from DNR to death was < 1 day. Mode of death was withdrawal of therapy in 33/77 (43 %), no cardiopulmonary resuscitation (CPR) in 26/77 (34 %), andfailed CPR in 13/77 (17%). Five children were declared brain dead. In only one case was there evidence in the medical record of the possibility of death being discussed explicitly with the patient. Decision-making regarding end-of-life issues in this pediatric population was deferred very close to the time of death, and only after no remaining curative therapy was available. Acuity of care was very high prior to death. Children are rarely told that they are dying.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(00)00212-8" target="_blank" rel="noreferrer">10.1016/s0885-3924(00)00212-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Backlog
Bruera E
Byrne P
Canuck Place 15 year chart review
Child
Children
Communication
Critical Care
Death
DNAR
Dying
Euthanasia
Hospital Mortality
Human
Humans
Infant
Infant Mortality
Infants
Journal Article
Journal of Pain and Symptom Management
Longitudinal Studies
McCallum DE
Palliative Care
Passive
Pediatric Intensive Care Unit
Preschool
Resuscitation Orders
Symptoms
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(97)00075-4" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(97)00075-4</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Female; Humans; Male; Pain; Adult; Analgesics; Aged; Middle Aged; Treatment Outcome; Analysis of Variance; Chi-Square Distribution; Cross-Over Studies; 80 and over; Comparative Study; Injections; Intravenous; Dose-Response Relationship; Drug; Clodronate; Pain Measurement/drug effects; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage; Intractable/drug therapy/etiology; Bone Neoplasms/complications/secondary
Creator
An entity primarily responsible for making the resource
Ernst DS; Brasher P; Hagen N; Paterson AH; MacDonald RN; Bruera E
Description
An account of the resource
To evaluate the effectiveness of intravenous clodronate in ameliorating refractory bone pain in patients with metastatic bone disease, 60 patients with established osseous metastases and persistent bone pain were randomized to receive either clodronate (600 mg or 1500 mg in 500 mL of normal saline) or 500 mL of saline as placebo. After 2 weeks, the patients were crossed over to receive the alternate treatment. After another 2 weeks, each patient and investigator made a blinded choice. Daily visual analogue scales (VAS) and analgesic diaries were recorded throughout the study period. Forty-six patients were evaluable (77%). A treatment x period interaction was identified in the VAS and daily morphine equivalent dose (DMED) scores. First period analysis of the VAS scores for general pain, pain at rest, and pain upon movement demonstrated an average reduction of 13, 14, and 24 mm, respectively, from baseline, but were not significantly different from changes following placebo. The average change in DMED was -6.4 (SE = 2.9) following clodronate and was +24.6 (SE = 14.9) following placebo (p = 0.03). In the blinded choice of which agent resulted in improvement in pain, 26 (57%) patients chose clodronate, 12 (26%) chose placebo, and eight (17%) had no preference (p = 0.0021). For the investigators who also made a blinded selection, clodronate was chosen in 30 (65%) patients, placebo in ten (22%) patients, and no difference was apparent in six (13%) (p < 0.0001). Intravenous clodronate appeared to have analgesic effect in patients with refractory bone pain due to metastatic bone disease. The optimal dose and duration of effect require further evaluation, particularly in patients with stable disease and persistent bone pain.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(97)00075-4" target="_blank" rel="noreferrer">10.1016/s0885-3924(97)00075-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
80 And Over
Adult
Aged
Analgesics
Analysis of Variance
Backlog
Bone Neoplasms/complications/secondary
Brasher P
Bruera E
Chi-Square Distribution
Clodronate
Clodronic Acid/administration & dosage
Comparative Study
Cross-Over Studies
Dose-Response Relationship
Drug
Ernst DS
Female
Hagen N
Humans
Injections
Intractable/drug therapy/etiology
Intravenous
Journal Article
Journal of Pain and Symptom Management
MacDonald RN
Male
Middle Aged
Non-Narcotic/administration & dosage
Pain
Pain Measurement/drug effects
Paterson AH
Treatment Outcome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1023/a:1008274608267" target="_blank" rel="noreferrer">http://doi.org/10.1023/a:1008274608267</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Subcutaneous clodronate: a study evaluating efficacy in hypercalcemia of malignancy and local toxicity
Publisher
An entity responsible for making the resource available
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Female; Humans; Male; Aged; Middle Aged; 80 and over; Injections; Neoplasms/complications; Subcutaneous; Clodronate; Hypercalcemia/drug therapy; Clodronic Acid/administration & dosage/adverse effects
Creator
An entity primarily responsible for making the resource
Walker P; Watanabe S; Lawlor P; Hanson J; Pereira J; Bruera E
Description
An account of the resource
The logistics of administering intravenous bisphosphonates may be problematic in the care of advanced cancer patients, especially in the home setting. Hypodermoclysis is a convenient method of administering fluid via subcutaneous infusion, presently used in the domiciliary setting. Results of the administration of clodronate via this route are reported.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1023/a:1008274608267" target="_blank" rel="noreferrer">10.1023/a:1008274608267</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
80 And Over
Aged
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo
Backlog
Bruera E
Clodronate
Clodronic Acid/administration & dosage/adverse effects
Female
Hanson J
Humans
Hypercalcemia/drug therapy
Injections
Journal Article
Lawlor P
Male
Middle Aged
Neoplasms/complications
Pereira J
Subcutaneous
Walker P
Watanabe S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1177/026921639701100102" target="_blank" rel="noreferrer">http://doi.org/10.1177/026921639701100102</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Validity of the McGill Quality of Life Questionnaire in the palliative care setting: a multi-centre Canadian study demonstrating the importance of the existential domain
Publisher
An entity responsible for making the resource available
Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Humans; Palliative Care; Questionnaires; Longitudinal Studies; Mental Health; Sensitivity and Specificity; Reproducibility of Results; quality of life; Neoplasms/psychology; Mental Status Schedule; Multicenter Studies as Topic
Creator
An entity primarily responsible for making the resource
Cohen SR; Mount BM; Bruera E; Provost M; Rowe J; Tong K
Description
An account of the resource
This study was carried out in eight palliative care services in four Canadian cities. A revised version of The McGill Quality of Life Questionnaire (MQOL) is compared to a single-item scale measuring overall quality of life (SIS), and the self-administered version of the Spitzer Quality of Life Index (SA-QLI), to obtain evidence of validity. MQOL total score predicts SIS better than does SA-QLI, although much of the variance remains to be explained. The results of principal components analysis of data using this revised version of MQOL are similar to those from previous MQOL studies with different patient populations. The MQOL subscales, constructed on the basis of principal components analysis, demonstrate acceptable internal consistency reliability. The MQOL measures reflecting physical well-being and existential well-being are important for predicting SIS.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/026921639701100102" target="_blank" rel="noreferrer">10.1177/026921639701100102</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
Backlog
Bruera E
Cohen SR
Humans
Journal Article
Longitudinal Studies
Mental Health
Mental Status Schedule
Mount BM
Multicenter Studies as Topic
Neoplasms/psychology
Palliative Care
Palliative Medicine
Provost M
Quality Of Life
Questionnaires
Reproducibility of Results
Rowe J
Sensitivity and Specificity
Tong K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1191/026921600674582192" target="_blank" rel="noreferrer">http://doi.org/10.1191/026921600674582192</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Attitudes and beliefs of palliative care physicians regarding communication with terminally ill cancer patients.
Publisher
An entity responsible for making the resource available
Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Female; Humans; Male; Canada; Prognosis; Prospective Studies; Patient-Centered Care; Resuscitation Orders; Cross-Cultural Comparison; Europe; DNAR; Truth Disclosure; Palliative Care/px [Psychology]; Family/px [Psychology]; Physician-Patient Relations; Terminally Ill/px [Psychology]; Attitude of Health Personnel; Neoplasms/px [Psychology]; South America
Creator
An entity primarily responsible for making the resource
Bruera E; Neumann CM; Mazzocato C; Stiefel F; Sala R
Description
An account of the resource
The subject of communication between palliative care physicians and their patients regarding their diagnosis and prognosis has not been extensively researched. The purpose of this survey was to compare the attitudes and beliefs of palliative care specialists regarding communication with the terminally ill in Europe, South America, and Canada. A sample of palliative care physicians from South America (Argentina and Brazil), French-speaking Europe, and Canada were identified, and posted a questionnaire. Physicians who stated that they practised palliative care at least 30% of their time were considered evaluable as palliative care specialists. Of a total of 272 questionnaires, 228 were returned (84%); and 182/228 (81%) respondents were considered to be palliative care specialists. Palliative care physicians in all three regions believed that cancer patients should be informed of their diagnosis and the terminal nature of their illness. Physicians reported that at least 60% of their patients knew their diagnosis and the terminal stage of their illness in 52% and 24% of cases in South America, and 69% and 38% of cases in Europe, respectively. All physicians agreed that 'do not resuscitate' orders should be present, and should be discussed with the patient in all cases. While 93% of Canadian physicians stated that at least 60% of their patients wanted to know about the terminal stage of their illness, only 18% of South American, and 26% of European physicians said this (P < 0.001). Similar results were found when the physicians were asked the percentage of families who want patients to know the terminal stage of their illness. However, almost all of the physicians agreed that if they had terminal cancer they would like to know. There was a significant association between patient based decision-making and female sex (P = 0.007), older age (P = 0.04), and physicians from Canada and South America (P < 0.001). Finally, in their daily decision making, South American physicians were significantly more likely to support beneficence and justice as compared with autonomy. Canadian physicians were more likely to support autonomy as compared with beneficence. In summary, our findings suggest that there are major regional differences in the attitudes and beliefs of physicians regarding communication at the end of life. More research is badly needed on the attitudes and beliefs of patients, families, and health care professionals in different regions of the world.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1191/026921600674582192" target="_blank" rel="noreferrer">10.1191/026921600674582192</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Attitude Of Health Personnel
Backlog
Bruera E
Canada
Cross-cultural Comparison
DNAR
Europe
Family/px [psychology]
Female
Humans
Journal Article
Male
Mazzocato C
Neoplasms/px [psychology]
Neumann CM
Palliative Care/px [psychology]
Palliative Medicine
Patient-centered Care
Physician-patient Relations
Prognosis
Prospective Studies
Resuscitation Orders
Sala R
South America
Stiefel F
Terminally Ill/px [Psychology]
Truth Disclosure
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1191/026921601668441770" target="_blank" rel="noreferrer">http://doi.org/10.1191/026921601668441770</a>
<a href="http://pmj.sagepub.com/cgi/doi/10.1191/026921601668441770" target="_blank" rel="noreferrer">http://pmj.sagepub.com/cgi/doi/10.1191/026921601668441770</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Clinical research in palliative care: patient populations, symptoms, interventions and endpoints
Publisher
An entity responsible for making the resource available
Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Creator
An entity primarily responsible for making the resource
Mazzocato C; Sweeney C; Bruera E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1191/026921601668441770" target="_blank" rel="noreferrer">10.1191/026921601668441770</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2001-03
2001
Backlog
Bruera E
Journal Article
Mazzocato C
Palliative Medicine
Sweeney C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11324184" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11324184</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Palliative care on the net: an online survey of health care professionals
Publisher
An entity responsible for making the resource available
Journal Of Palliative Care
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Female; Male; Adult; Questionnaires; Aged; Middle Aged; Computer Communication Networks; Practice; Attitudes; Health Knowledge; Human; Databases; Periodicals; Attitude of Health Personnel; Attitude to Computers; Factual/utilization; Health Personnel/psychology/statistics & numerical data; Information Services/utilization; Internet/utilization; Nurses/psychology/statistics & numerical data; Online Systems/utilization; Pharmacists/psychology/statistics & numerical data; Physicians/psychology/statistics & numerical data; Terminal Care/statistics & numerical data
Creator
An entity primarily responsible for making the resource
Pereira J; Bruera E; Quan H
Description
An account of the resource
A survey was conducted to explore Internet use by palliative care health professionals (HCP). The survey was placed on the World Wide Web with an underlying database, and palliative care HCP were invited to participate via a palliative-care-related website, listserv, and newsletter. A total of 417 evaluable responses were received over a four-month period. Of these, 36% indicated they were from physicians and 30% from nurses, a third of respondents were practicing palliative care full time. Although 63% of respondents were from North America, regions from all over the world were represented. Eighty-eight percent of respondents were searching the Internet for clinical information, 80% were using email, 69% were accessing online medical journals, and 59% were subscribers to a palliative-care-related listserv or newsgroup. This survey illustrates the global outreach of the Internet and draws attention to the growing interest in the use of the Internet for education, research, and clinical use. Further development of online resources should address the needs of users. Evaluation of these resources is called for.
2001
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
Adult
Aged
Attitude Of Health Personnel
Attitude to Computers
Attitudes
Backlog
Bruera E
Computer Communication Networks
Databases
Factual/utilization
Female
Health Knowledge
Health Personnel/psychology/statistics & numerical data
Human
Information Services/utilization
Internet/utilization
Journal Article
Journal Of Palliative Care
Male
Middle Aged
Nurses/psychology/statistics & numerical data
Online Systems/utilization
Pereira J
Periodicals
Pharmacists/psychology/statistics & numerical data
Physicians/psychology/statistics & numerical data
Practice
Quan H
Questionnaires
Terminal Care/statistics & Numerical Data