1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1215/15228517-2007-038" target="_blank" rel="noreferrer">http://doi.org/10.1215/15228517-2007-038</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma
Publisher
An entity responsible for making the resource available
Neuro-oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
Subject
The topic of the resource
adolescent; Female; Humans; Male; Adult; Prognosis; Aged; Middle Aged; Treatment Outcome; Kaplan-Meier Estimate; Antineoplastic Agents; Combined Modality Therapy; 80 and over; Brain neoplasms; Disease-Free Survival; Local; Glioblastoma; Neoplasm Recurrence; Neurosurgical Procedures; Radiotherapy
Creator
An entity primarily responsible for making the resource
Filippini G; Falcone C; Boiardi A; Broggi G; Bruzzone MG; Caldiroli D; Farina R; Farinotti M; Fariselli L; Finocchiaro G; Giombini S; Pollo B; Savoiardo M; Solero CL; Valsecchi MG; Brain Cancer Register of the Fondazione IRCCS (Istituto Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo Besta
Description
An account of the resource
Reliable data on large cohorts of patients with glioblastoma are needed because such studies differ importantly from trials that have a strong bias toward the recruitment of younger patients with a higher performance status. We analyzed the outcome of 676 patients with histologically confirmed newly diagnosed glioblastoma who were treated consecutively at a single institution over a 7-year period (1997-2003) with follow-up to April 30, 2006. Survival probabilities were 57% at 1 year, 16% at 2 years, and 7% at 3 years. Progression-free survival was 15% at 1 year. Prolongation of survival was significantly associated with surgery in patients with a good performance status, whatever the patient's age, with an adjusted hazard ratio of 0.55 (p < 0.001) or a 45% relative decrease in the risk of death. Radiotherapy and chemotherapy improved survival, with adjusted hazard ratios of 0.61 (p = 0.001) and 0.89 (p = 0.04), respectively, regardless of age, performance status, or residual tumor volume. Recurrence occurred in 99% of patients throughout the follow-up. Reoperation was performed in one-fourth of these patients but was not effective, whether performed within 9 months (hazard ratio, 0.86; p = 0.256) or after 9 months (hazard ratio, 0.98; p = 0.860) of initial surgery, whereas second-line chemotherapy with procarbazine, lomustine, and vincristine (PCV) or with temozolomide improved survival (hazard ratio, 0.77; p = 0.008). Surgery followed by radiotherapy and chemotherapy should be considered in all patients with glioblastoma, and these treatments should not be withheld because of increasing age alone. The benefit of second surgery at recurrence is uncertain, and new trials are needed to assess its effectiveness. Chemotherapy with PCV or temozolomide seems to be a reasonable option at tumor recurrence.
2008-02
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1215/15228517-2007-038" target="_blank" rel="noreferrer">10.1215/15228517-2007-038</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2008
80 And Over
Adolescent
Adult
Aged
Antineoplastic Agents
Backlog
Boiardi A
Brain Cancer Register of the Fondazione IRCCS (Istituto Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo Besta
Brain Neoplasms
Broggi G
Bruzzone MG
Caldiroli D
Combined Modality Therapy
Disease-Free Survival
Falcone C
Farina R
Farinotti M
Fariselli L
Female
Filippini G
Finocchiaro G
Giombini S
Glioblastoma
Humans
Journal Article
Kaplan-Meier Estimate
Local
Male
Middle Aged
Neoplasm Recurrence
Neuro-oncology
Neurosurgical Procedures
Pollo B
Prognosis
Radiotherapy
Savoiardo M
Solero CL
Treatment Outcome
Valsecchi MG