1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1212/01.wnl.0000324624.52935.46" target="_blank" rel="noreferrer">http://doi.org/10.1212/01.wnl.0000324624.52935.46</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery
Publisher
An entity responsible for making the resource available
Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
Subject
The topic of the resource
Female; Humans; Male; Adult; Follow-Up Studies; Aged; Middle Aged; Treatment Outcome; 80 and over; retrospective studies; Anticonvulsants/administration & dosage/adverse effects; Brain Injuries/complications/surgery; Brain/drug effects/physiopathology/surgery; Drug Tolerance/physiology; Drug Toxicity; Epilepsy/drug therapy/etiology/prevention & control; Neurosurgical Procedures/adverse effects; Phenytoin/administration & dosage/adverse effects; Piracetam/administration & dosage/adverse effects/analogs & derivatives; Postoperative Complications/drug therapy/prevention & control; Supratentorial Neoplasms/complications/surgery
Creator
An entity primarily responsible for making the resource
Milligan TA; Hurwitz S; Bromfield EB
Description
An account of the resource
BACKGROUND: Antiepileptic drugs are routinely given after craniotomy. Though phenytoin (PHT) is still the most commonly used agent, levetiracetam (LEV) is increasingly administered for this purpose. This retrospective study compared the use of LEV and PHT as monotherapy prophylaxis following supratentorial neurosurgery. METHODS: Patients receiving LEV monotherapy after supratentorial craniotomy were reviewed and compared to a control group of patients receiving PHT monotherapy. RESULTS: One of 105 patients taking LEV and 9/210 patients taking PHT had seizures within 7 days of surgery (p = 0.17). Adverse drug reactions requiring change in therapy during hospitalization occurred in 1/105 patients taking LEV and 38/210 patients taking PHT (p < 0.001). Among patients followed for at least 12 months, 11/42 (26%) treated with LEV vs 42/117 (36%) treated with PHT developed epilepsy (p = 0.34); 64% remained on LEV, while 26% remained on PHT (p = 0.03). CONCLUSIONS: Both levetiracetam (LEV) and phenytoin (PHT) were associated with a low risk of early postoperative seizures and a moderate risk of later epilepsy. LEV was associated with significantly fewer early adverse reactions than PHT and with a higher retention rate in patients who were followed for at least 1 year and developed epilepsy.
2008
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1212/01.wnl.0000324624.52935.46" target="_blank" rel="noreferrer">10.1212/01.wnl.0000324624.52935.46</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2008
80 And Over
Adult
Aged
Anticonvulsants/administration & dosage/adverse effects
Backlog
Brain Injuries/complications/surgery
Brain/drug effects/physiopathology/surgery
Bromfield EB
Drug Tolerance/physiology
Drug Toxicity
Epilepsy/drug therapy/etiology/prevention & control
Female
Follow-up Studies
Humans
Hurwitz S
Journal Article
Male
Middle Aged
Milligan TA
Neurology
Neurosurgical Procedures/adverse effects
Phenytoin/administration & dosage/adverse effects
Piracetam/administration & dosage/adverse effects/analogs & derivatives
Postoperative Complications/drug therapy/prevention & control
Retrospective Studies
Supratentorial Neoplasms/complications/surgery
Treatment Outcome