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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1136/adc.2003.036590" target="_blank" rel="noreferrer">http://doi.org/10.1136/adc.2003.036590</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonate treatment of bone disease
Publisher
An entity responsible for making the resource available
Archives Of Disease In Childhood
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Child; Humans; Male; Treatment Outcome; Time Factors; adolescent; Preschool; Administration; Oral; Injections; Intravenous; Calcinosis/drug therapy; Bone Diseases/drug therapy; Hypercalcemia/drug therapy; Bone Resorption/drug therapy; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Osteogenesis Imperfecta/drug therapy
Creator
An entity primarily responsible for making the resource
Shaw NJ; Bishop NJ
Description
An account of the resource
In 1997 a review article on bisphosphonates in this journal identified 24 published articles relating to children at that time. Since then there has been a considerable increase in their use in clinical paediatric practice and research with there being nearly a further one hundred articles published at the time of writing.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/adc.2003.036590" target="_blank" rel="noreferrer">10.1136/adc.2003.036590</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Administration
Adolescent
Archives of Disease in Childhood
Backlog
Bishop NJ
Bone Diseases/drug therapy
Bone Resorption/drug therapy
Calcinosis/drug therapy
Child
Diphosphonates/administration & dosage/adverse effects/therapeutic use
Humans
Hypercalcemia/drug therapy
Injections
Intravenous
Journal Article
Male
Oral
Osteogenesis Imperfecta/drug therapy
Preschool
Shaw NJ
Time Factors
Treatment Outcome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/nejm199810013391402" target="_blank" rel="noreferrer">http://doi.org/10.1056/nejm199810013391402</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cyclic administration of pamidronate in children with severe osteogenesis imperfecta
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Child; Female; Humans; Male; Drug Administration Schedule; adolescent; Preschool; Non-U.S. Gov't; Research Support; Pain/drug therapy; Clodronate; Bone Density/drug effects; Periodicity; Diphosphonates/administration & dosage; Alkaline Phosphatase/blood; Bone Development/drug effects; Bone Resorption/drug therapy; Bone/prevention & control; Calcium/urine; Fractures; Lumbar Vertebrae/physiopathology/radiography; Osteogenesis Imperfecta/drug therapy/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Glorieux FH; Bishop NJ; Plotkin H; Chabot G; Lanoue G; Travers R
Description
An account of the resource
BACKGROUND: Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We assessed the effects of treatment with a bisphosphonate on bone resorption. METHODS: In an uncontrolled observational study involving 30 children who were 3 to 16 years old and had severe osteogenesis imperfecta, we administered pamidronate intravenously (mean [+/-SD] dose, 6.8+/-1.1 mg per kilogram of body weight per year) at 4-to-6-month intervals for 1.3 to 5.0 years. Clinical status, biochemical characteristics reflecting bone turnover, the bone mineral density of the lumbar spine, and radiologic changes were assessed regularly during treatment. RESULTS: Administration of pamidronate resulted in sustained reductions in serum alkaline phosphatase concentrations and in the urinary excretion of calcium and type I collagen N-telopeptide. There was a mean annualized increase of 41.9+/-29.0 percent in bone mineral density, and the deviation of bone mineral density from normal, as indicated by the z score, improved from -5.3+/-1.2 to -3.4+/-1.5. The cortical width of the metacarpals increased by 27+/-20.2 percent per year. The increases in the size of the vertebral bodies suggested that new bone had formed. The mean incidence of radiologically confirmed fractures decreased by 1.7 per year (P<0.001). Treatment with pamidronate did not alter the rate of fracture healing, the growth rate, or the appearance of the growth plates. Mobility and ambulation improved in 16 children and remained unchanged in the other 14. All the children reported substantial relief of chronic pain and fatigue. CONCLUSIONS: In children with severe osteogenesis imperfecta, cyclic administration of intravenous pamidronate improved clinical outcomes, reduced bone resorption, and increased bone density.
1998
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/nejm199810013391402" target="_blank" rel="noreferrer">10.1056/nejm199810013391402</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1998
Adolescent
Alkaline Phosphatase/blood
Backlog
Bishop NJ
Bone Density/drug effects
Bone Development/drug effects
Bone Resorption/drug therapy
Bone/prevention & control
Calcium/urine
Chabot G
Child
Clodronate
Diphosphonates/administration & dosage
Drug Administration Schedule
Female
Fractures
Glorieux FH
Humans
Journal Article
Lanoue G
Lumbar Vertebrae/physiopathology/radiography
Male
Non-U.S. Gov't
Osteogenesis Imperfecta/drug therapy/metabolism/physiopathology
Pain/drug Therapy
Periodicity
Plotkin H
Preschool
Research Support
The New England Journal Of Medicine
Travers R