Bisphosphonate treatment of bone disease
Child; Humans; Male; Treatment Outcome; Time Factors; adolescent; Preschool; Administration; Oral; Injections; Intravenous; Calcinosis/drug therapy; Bone Diseases/drug therapy; Hypercalcemia/drug therapy; Bone Resorption/drug therapy; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Osteogenesis Imperfecta/drug therapy
In 1997 a review article on bisphosphonates in this journal identified 24 published articles relating to children at that time. Since then there has been a considerable increase in their use in clinical paediatric practice and research with there being nearly a further one hundred articles published at the time of writing.
2005
Shaw NJ; Bishop NJ
Archives Of Disease In Childhood
2005
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1136/adc.2003.036590" target="_blank" rel="noreferrer">10.1136/adc.2003.036590</a>
Expanding role of bisphosphonate therapy in children
Child; Humans; Clodronate; Calcinosis/drug therapy; Bone Diseases/drug therapy; Diphosphonates/pharmacokinetics/pharmacology/therapeutic use; Hypercalcemia/drug therapy
1999
Shoemaker LR
The Journal Of Pediatrics
1999
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/s0022-3476(99)70447-6" target="_blank" rel="noreferrer">10.1016/s0022-3476(99)70447-6</a>
Biphosphonates
Child; Female; Humans; Adult; adolescent; Preschool; Osteoporosis/drug therapy; Calcinosis/drug therapy; Bone Diseases/drug therapy; Hypercalcemia/drug therapy; Diphosphonates/adverse effects/pharmacology/therapeutic use
1997
Allgrove J
Archives Of Disease In Childhood
1997
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1136/adc.76.1.73" target="_blank" rel="noreferrer">10.1136/adc.76.1.73</a>
Bisphosphonates: from grandparents to grandchildren
Child; Female; Humans; Male; Adult; Aged; Middle Aged; Age Factors; adolescent; Preschool; Non-U.S. Gov't; Research Support; Administration; Oral; Clodronate; Bone Diseases/drug therapy; Hypercalcemia/drug therapy; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Osteogenesis Imperfecta/drug therapy; Osteoporosis; Postmenopausal/drug therapy
Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. Bisphosphonates have been extensively used in the elderly with primary and secondary osteoporosis, Paget's disease, and hypercalcemia of malignancy. In recent years, bisphosphonates have been used to treat children acutely for resistant hypercalcemia and chronically for various metabolic bone diseases. The theoretical concerns of possible adverse effects of these drugs on the growing skeleton have not been proven to be true. In the present review, we have critically analyzed the available literature on bisphosphonate therapy in both adult and pediatric clinical trials. Although not yet approved by the FDA for use in children, bisphosphonates, from published experience, demonstrate benefit to the child with no serious adverse effects. Based on the literature analysis the review furnishes detailed recommendations and practical guidelines regarding the use of oral and intravenous bisphosphonates in children. Bisphosphonates might be the first agents to provide the pediatrician with an opportunity to treat mineral and bone disorders of childhood, which until recently did not have satisfactory therapy.
1999
Srivastava T; Alon US
Clinical Pediatrics
1999
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1177/000992289903801201" target="_blank" rel="noreferrer">10.1177/000992289903801201</a>