1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1097/00003086-197610000-00018" target="_blank" rel="noreferrer">http://doi.org/10.1097/00003086-197610000-00018</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Diphosphonate treatment of Paget's disease Publisher An entity responsible for making the resource available Clinical Orthopaedics and Related Research Date A point or period of time associated with an event in the lifecycle of the resource 1976 Subject The topic of the resource Female; Humans; Male; Aged; Middle Aged; Clodronate; Alkaline Phosphatase/blood; Fractures; Bone/etiology; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Osteitis Deformans/drug therapy/metabolism/radiography; Osteomalacia/etiology; Proline/urine Creator An entity primarily responsible for making the resource Finerman GA; Gonick HC; Smith RK; Mayfield JM Description An account of the resource Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered in a dose of 20 mg/kg/d to 21 patients with symptomatic Paget's disease. All patients were treated for 6 months and then followed for an additional 6 months. There was a striking decline in serum alkaline phosphatase and urinary hydroxy-proline excretion observed after 3 months of therapy which was not significantly improved in the succeeding 3 months. Concomitantly there was marked improvement in clinical symptoms and bone scans. Following cessation of therapy, continued biochemical and clinical evidence of remission persisted. Several patients on repeat treatment with EHDP appeared to respond promptly. Side effects were minimal except for a possibly related osteomalacia and increased incidence of pathologic fractures. 1976 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/00003086-197610000-00018" target="_blank" rel="noreferrer">10.1097/00003086-197610000-00018</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 1976 Aged Alkaline Phosphatase/blood Backlog Bone/etiology Clinical Orthopaedics and Related Research Clodronate Diphosphonates/administration & dosage/adverse effects/therapeutic use Female Finerman GA Fractures Gonick HC Humans Journal Article Male Mayfield JM Middle Aged Osteitis Deformans/drug therapy/metabolism/radiography Osteomalacia/etiology Proline/urine Smith RK