Beta-endorphin levels of children in acute stress
Child; Humans; infant; Prognosis; Follow-Up Studies; Acute Disease; Preschool; infant; beta-Endorphin/blood; Biomarkers of Pain; Newborn; Biomarkers Reference List; Blood Glucose/analysis; Hyperglycemia/blood/epidemiology/pathology; Insulin/blood; Stress/blood/epidemiology
In this study aiming to clarify the relationships between beta-endorphin and glucose levels, beta-endorphin levels were determined in children in acute stress. The study was carried out on 32 critically ill children between 5 days and 12 years presenting with clinical symptoms of acute infectious conditions. 11 healthy children were taken as controls. The results showed that although beta-endorphin levels were elevated in all critically ill patients, these levels were significantly higher than control values in hyperglycaemic cases. The insulin levels were also elevated. A follow-up of nine of the hyperglycaemic cases showed a significant decline in beta-endorphin and insulin levels with recovery. Glucose tolerance was also normal. These results confirm the reports of many other studies on the role of beta-endorphin as a stress hormone.
1990
Dindar A; Gunoz H; Neyzi O
Diabetes Research And Clinical Practice
1990
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/0168-8227(90)90052-u" target="_blank" rel="noreferrer">10.1016/0168-8227(90)90052-u</a>
Brain metabolism during short-term starvation in humans
Female; Humans; Male; Adult; Time Factors; Tissue Distribution; Non-U.S. Gov't; Research Support; Emission-Computed; Tomography; Brain/metabolism; Starvation/metabolism; Blood Glucose/analysis; Ketone Bodies/metabolism; Arteries; Deoxyglucose/analogs & derivatives/metabolism; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose/metabolism; Osmolar Concentration
During prolonged starvation, brain energy requirements are covered in part by the metabolism of ketone bodies. It is unknown whether short-term starvation of a few days' duration may lead to reduced brain glucose metabolism due to the change toward ketone body consumption. In the present study we measured the cerebral metabolism of glucose and ketone bodies in nine healthy volunteers before and after 3.5 days of starvation. Regional glucose metabolism was measured by dynamic positron emission tomography using [18F]2-fluoro-2-deoxy-D-glucose. The mean value of K1* in gray and white matter increased by 12% (p < 0.05), whereas k2* and k3* were unchanged compared with control values. Regional glucose metabolism in cortical gray matter was reduced by 26% from 0.294 +/- 0.054 to 0.217 +/- 0.040 mumol g-1 min-1 (p < 0.001). White matter glucose metabolism decreased by 27% (p < 0.02). The decrease was uniform in gray and white matter with regional decreases ranging from 24 to 30%. A determination using Fick's principle confirmed the reduction in glucose metabolism yielding a decrease of 24% from 0.307 +/- 0.050 to 0.233 +/- 0.073 mumol g-1 min-1 (p < 0.05), whereas CBF did not change (0.57 +/- 0.07 vs. 0.57 +/- 0.06 ml g-1 min-1). The global net uptake of beta-hydroxybutyrate increased 13-fold from 0.012 +/- 0.024 to 0.155 +/- 0.140 mumol g-1 min-1 (p < 0.05). Net uptake of acetoacetate and net efflux of lactate and pyruvate did not change significantly during starvation. The present study shows that the human brain adapts to the changes in energy supply as early as 3 days following initiation of starvation, at which time ketone bodies account for approximately one-fourth of the cerebral energy requirements.
1994
Hasselbalch SG; Knudsen GM; Jakobsen J; Hageman LP; Holm S; Paulson OB
Journal Of Cerebral Blood Flow And Metabolism
1994
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1038/jcbfm.1994.17" target="_blank" rel="noreferrer">10.1038/jcbfm.1994.17</a>