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Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1080/j354v16n04_02" target="_blank" rel="noreferrer">http://doi.org/10.1080/j354v16n04_02</a>
Dublin Core
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Title
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Clinical pharmacokinetics of morphine
Publisher
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Journal of Pain and Palliative Care Pharmacotherapy
Date
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2002
Subject
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Child; Humans; infant; Adult; Aged; Drug Interactions; Biotransformation; Half-Life; Tissue Distribution; infant; Administration; Newborn; Oral; Injections; Intravenous; Delayed-Action Preparations; Aging/metabolism; Metabolic Clearance Rate; Dosage Forms; Intestinal Absorption; Morphine/administration & dosage/metabolism/pharmacokinetics; Neoplasms/metabolism
Creator
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Lugo RA; Kern SE
Description
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Morphine, the most widely used mu-opioid analgesic for acute and chronic pain, is the standard against which new analgesics are measured. A thorough understanding of the pharmacokinetics of morphine is required in order to safely and effectively use this analgesic in a wide variety of patients with different levels of organ function. A MEDLINE search was conducted to identify literature published between 1966 and January 2002 relevant to the pharmacokinetics of morphine. These publications were reviewed and the literature summarized regarding unique and clinically important elements of morphine disposition relative to its parenteral administration (including intravenous, intramuscular, subcutaneous, epidural and intrathecal administration), absorption profile (immediate release, controlled release, and sublingual/buccal, and rectal administration), distribution, and its metabolism/excretion. Special populations, including infants, elderly, and those with renal/liver failure, have a unique morphine pharmacokinetic profile that must be taken into account in order to maximize analgesic efficacy and reduce the risk of adverse events.
2002
Identifier
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<a href="http://doi.org/10.1080/j354v16n04_02" target="_blank" rel="noreferrer">10.1080/j354v16n04_02</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Administration
Adult
Aged
Aging/metabolism
Backlog
Biotransformation
Child
Delayed-Action Preparations
Dosage Forms
Drug Interactions
Half-Life
Humans
Infant
Injections
Intestinal Absorption
Intravenous
Journal Article
Journal of Pain and Palliative Care Pharmacotherapy
Kern SE
Lugo RA
Metabolic Clearance Rate
Morphine/administration & dosage/metabolism/pharmacokinetics
Neoplasms/metabolism
Newborn
Oral
Tissue Distribution