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Text
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URL Address
<a href="http://doi.org/10.1191/0269216304pm906ra" target="_blank" rel="noreferrer">http://doi.org/10.1191/0269216304pm906ra</a>
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Title
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Research methodology: cancer cachexia syndrome
Publisher
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Palliative Medicine
Date
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2004
Subject
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Humans; Prognosis; Ambulatory Care; quality of life; Nutritional Status; Neoplasms/complications; Cachexia/etiology; Body Composition; Weight Gain; Placebo Effect; Biomedical Research/methods; Exercise/physiology
Creator
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Dahele M; Fearon KC
Description
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Cachexia is a syndrome and therefore does not have a specific definition. Patients are characterized by the presence of anorexia, early satiety, weight loss, weakness, anaemia and oedema. These features occur to a variable extent in different patients and may change in severity during the course of a patient's illness. The multifactorial origin of cachexia precludes a uniform pathophysiological definition. Taken together these factors have hindered clinical studies both at a fundamental level and in terms of the introduction of effective therapy. The advent of novel therapeutic targets (e.g., ubiquitin-proteasome pathway) and biological response modifiers has opened possibilities for new clinical trials in cachexia. Regulatory authorities feel it is important not only to demonstrate efficacy in terms of patients' nutritional status (e.g., lean body mass) but also functional status (e.g., performance status). This article reviews current methods to assess the latter. Methods focused on measuring physical activity level (e.g., doubly labelled water technique or physical activity meters) promise objective data which can be readily interpreted in terms of clinically meaningful benefit.
2004
Identifier
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<a href="http://doi.org/10.1191/0269216304pm906ra" target="_blank" rel="noreferrer">10.1191/0269216304pm906ra</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2004
Ambulatory Care
Backlog
Biomedical Research/methods
Body Composition
Cachexia/etiology
Dahele M
Exercise/physiology
Fearon KC
Humans
Journal Article
Neoplasms/complications
Nutritional Status
Palliative Medicine
Placebo Effect
Prognosis
Quality Of Life
Weight Gain