1
40
84
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Dublin Core
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Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
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URL Address
<a href="http://doi.org/10.1002/ana.410270112" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ana.410270112</a>
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Title
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Naltrexone therapy of apnea in children with elevated cerebrospinal fluid beta-endorphin
Publisher
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Annals of Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
Subject
The topic of the resource
beta-Endorphin/cerebrospinal fluid; Male; Sleep Apnea Syndromes/cerebrospinal fluid/drug therapy; Infant Newborn; Leigh Disease/cerebrospinal fluid; Child; Humans; Prospective Studies; Naltrexone/therapeutic use; Female; Child Preschool; Infant; Biomarkers of Pain; child; female; male; beta-Endorphin/cerebrospinal fluid; Naltrexone/therapeutic use; Sleep Apnea Syndromes/cerebrospinal fluid/drug therapy; breathing difficulties; Leigh syndrome; pharmacologic intervention; oral naltrexone; naltrexone; sleep apnea
Creator
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Myer E C; Morris D L; Brase D A; Dewey W L; Zimmerman A W
Description
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Previous studies have indicated increased immunoreactivity of the endogenous opioid peptide beta-endorphin in the cerebrospinal fluid (CSF) of infants under 2 years of age with apnea. To assess the role of endogenous opioids in the pathogenesis of apnea in children, the effect of oral treatment with the opioid antagonist naltrexone was studied in apneic infants, as well as in older apneic children, with demonstrated increases in CSF immunoreactive beta-endorphin (i-BE). In the 8 apneic infants with elevated i-BE in lumbar CSF (range, 55-155 pg/ml; normal, 17-52 pg/ml), no further apnea occurred during naltrexone therapy (1 mg/kg/day, by mouth). Five children (2-8 years old) with apnea of unknown cause had elevated CSF i-BE (range, 74-276 pg/ml) compared to 6 age-matched nonapneic children (range, 15-48 pg/ml). No apneic events occurred during naltrexone therapy, except in 1 child during stressful events, but apnea recurred in some patients after attempts to discontinue naltrexone treatment. Adverse effects of naltrexone included complaints of headaches in 2 children and symptoms of a narcotic withdrawal syndrome during the first 3 days of treatment in 1 child. Three children with Leigh's syndrome had elevated CSF i-BE (range, 104-291 pg/ml) and their apnea also responded to naltrexone. We conclude that elevated endogenous opioids contribute to the pathogenesis of apnea in children and may even result in physical dependence.
Identifier
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<a href="http://doi.org/10.1002/ana.410270112" target="_blank" rel="noreferrer noopener">10.1002/ana.410270112</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Annals Of Neurology
beta-Endorphin/cerebrospinal fluid
Biomarkers of Pain
Brase D A
breathing difficulties
Child
Child Preschool
Dewey W L
Female
Humans
Infant
Infant Newborn
Leigh Disease/cerebrospinal fluid
Leigh syndrome
Male
Morris D L
Myer E C
Naltrexone
Naltrexone/therapeutic use
oral naltrexone
pharmacologic intervention
Prospective Studies
Sleep apnea
Sleep Apnea Syndromes/cerebrospinal fluid/drug therapy
Zimmerman A W
-
Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/pme.12248" target="_blank" rel="noreferrer">http://doi.org/10.1111/pme.12248</a>
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Title
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Do Low Levels of Beta-Endorphin in the Cerebrospinal Fluid Indicate Defective Top-Down Inhibition in Patients with Chronic Neuropathic Pain? A Cross-Sectional, Comparative Study
Publisher
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Pain Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
Subject
The topic of the resource
Biomarkers of Pain
Creator
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Backryd E; Ghafouri B; Larsson B; Gerdle B
Description
An account of the resource
OBJECTIVE: Pain medicine still lacks mechanism-specific biomarkers to guide diagnosis and treatment, and defective top-down modulation is an important factor in the pathophysiology of chronic pain conditions. Using modern analytical tools and advanced multivariate statistical analysis, the aim of this study was to revisit two classical potential biomarkers of pro- and anti-nociception in humans (substance P and beta-endorphin), focusing particularly on the cerebrospinal fluid (CSF). DESIGN: Cross-sectional, comparative, observational study. SUBJECTS: Patients with chronic, post-traumatic and/or post-surgical, neuropathic pain refractory to conventional treatment (N = 15) and healthy controls (N = 19) were included. METHODS: Samples were taken from CSF and blood, and levels of substance P and beta-endorphin were investigated using a Luminex technology kit. RESULTS: We found low levels of beta-endorphin in the CSF of neuropathic pain patients (66 ± 11 pcg/mL) compared with healthy controls (115 ± 14 pcg/mL) (P = 0.017). Substance P levels in the CSF did not differ (20 ± 2 pcg/mL, 26 ± 2, P = 0.08). However, our multivariate data analysis showed that belonging to the patient group was associated with low levels of both substances in the CSF. A higher correlation between the levels of beta-endorphin and substance P in CSF was found in healthy controls than in patients (rs = 0.725, P < 0.001 vs. rs = 0.574, P = 0.032). CONCLUSIONS: Patients with chronic neuropathic pain due to trauma or surgery had low levels of beta-endorphin in the CSF. We speculate that this could indicate a defective top-down modulation of pain in chronic neuropathic pain. Our results also illustrate the importance of taking a system-wide, multivariate approach when searching for biomarkers.
2014-01
Identifier
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<a href="http://doi.org/10.1111/pme.12248" target="_blank" rel="noreferrer">10.1111/pme.12248</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2014
Backlog
Backryd E
Biomarkers of Pain
Gerdle B
Ghafouri B
Journal Article
Larsson B
Pain Medicine
-
Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/mas.20120" target="_blank" rel="noreferrer">http://doi.org/10.1002/mas.20120</a>
Dublin Core
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Title
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Mass spectrometry for the quantification of bioactive peptides in biological fluids
Publisher
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Mass Spectrometry Reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Biomarkers of Pain; Body Fluids/metabolism; Chemical Fractionation/methods; Mass Spectrometry/methods; Peptides/analysis/chemistry; Pharmaceutical Preparations/analysis/chemistry; Specimen Handling/methods
Creator
An entity primarily responsible for making the resource
Tamvakopoulos C
Description
An account of the resource
The study of pharmacologically active peptides is central to the understanding of disease and development of novel therapies. It would be advantageous to monitor the fate of bioactive peptides in biological fluids and tissues following their in vivo administration (exogenous administration) or the modulation of endogenous factors (e.g., peptide hormones) affected by the administration of a pharmacological agent. Measurement of administered compounds (small molecules) in plasma is a mature field. However, measurement of pharmacologically active peptides presents particular problems for quantitative mass spectrometry, including challenges from selectivity and sensitivity perspectives. Current approaches towards peptide quantification in biological fluids include immunoassays and mass spectrometric techniques. Immunoassays, although sensitive, lack the necessary selectivity for distinction between peptide and metabolites. Modified molecules induced by metabolic transformations (e.g., N- or C-terminal truncation of the peptide) might not be differentiated by the antibody used in the assay, leading to cross-reactivity. However, although it is generally accepted that mass spectrometry is an ideal technique for the quantification of trace levels of analytes in biological fluids, immunological techniques are still characterized by better limits of peptide detection. In this review article, novel mass spectrometric approaches and strategies on peptide quantification will be described. The current capabilities and prospects for advances in this critical area of research will be examined.
2007
Identifier
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<a href="http://doi.org/10.1002/mas.20120" target="_blank" rel="noreferrer">10.1002/mas.20120</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Backlog
Biomarkers of Pain
Body Fluids/metabolism
Chemical Fractionation/methods
Journal Article
Mass Spectrometry Reviews
Mass Spectrometry/methods
Peptides/analysis/chemistry
Pharmaceutical Preparations/analysis/chemistry
Specimen Handling/methods
Tamvakopoulos C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">http://doi.org/10.1007/978-3-540-33823-9_2</a>
Dublin Core
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Title
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Opioids
Publisher
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Handbook Of Experimental Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Humans; Analgesics; Animals; Molecular Sequence Data; Chronic disease; Biomarkers of Pain; Drug Tolerance; Receptors; Amino Acid Sequence; Ligands; Opioid/adverse effects/pharmacology/therapeutic use; Opioid/drug effects
Creator
An entity primarily responsible for making the resource
Zollner C; Stein C
Description
An account of the resource
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (mu, delta, kappa) have been identified. Multiple pathways ofopioid receptor signaling (e.g., G(i/o) coupling, cAMP inhibition, Ca++ channel inhibition) have been described. The differential regulation of effectors, preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter.
2007
Identifier
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<a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">10.1007/978-3-540-33823-9_2</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Amino Acid Sequence
Analgesics
Animals
Backlog
Biomarkers of Pain
Chronic Disease
Drug Tolerance
Handbook Of Experimental Pharmacology
Humans
Journal Article
Ligands
Molecular Sequence Data
Opioid/adverse effects/pharmacology/therapeutic use
Opioid/drug effects
Receptors
Stein C
Zollner C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.bbi.2006.10.014" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.bbi.2006.10.014</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Influence of pain treatment by epidural fentanyl and bupivacaine on homing of opioid-containing leukocytes to surgical wounds
Publisher
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Brain, Behavior, And Immunity
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Female; Humans; Male; Pain; Analgesics; Aged; Middle Aged; Longitudinal Studies; Analgesia; Anesthetics; Biomarkers of Pain; Anesthesia; Epidural; Enkephalin; Adjuvants; Anesthesia/immunology/pharmacology; beta-Endorphin/drug effects/immunology/metabolism; Bupivacaine/immunology/therapeutic use; Cell Movement/drug effects/immunology; Fentanyl/immunology/therapeutic use; Leukocytes/drug effects/immunology/metabolism; Local/immunology/therapeutic use; Methionine/drug effects/immunology/metabolism; Nociceptors/drug effects/immunology; Opioid/immunology/therapeutic use; Patient-Controlled; Pirinitramide/therapeutic use; Postganglionic/drug effects/immunology; Postoperative/immunology/prevention & control; Subcutaneous Tissue/immunology; Sympathetic Fibers; Wound Healing/drug effects/immunology
Creator
An entity primarily responsible for making the resource
Heurich M; Mousa SA; Lenzner M; Morciniec P; Kopf A; Welte M; Stein C
Description
An account of the resource
Endogenous opioids released from leukocytes extravasating into injured tissue can interact with peripheral opioid receptors to inhibit nociception. Animal studies have shown that the homing of opioid-producing leukocytes to the injured site is modulated by spinal blockade of noxious input. This study investigated whether epidural analgesia (EDA) influences the migration of beta-endorphin (END) and/or met-enkephalin (ENK)-containing leukocytes into the subcutaneous wound tissue of patients undergoing abdominal surgery. In part I patients received general anesthesia combined either with intra- and postoperative EDA (with bupivacaine and fentanyl) or with postoperative patient controlled intravenous analgesia (PCIA; with the opioid piritramide). In part II patients received general anesthesia combined with either epidural fentanyl or bupivacaine which was continued postoperatively. Samples of cutanous and subcutanous tissue were taken from the wound site at the beginning, at the end and at various times after surgery, and were examined by immunohistochemistry for the presence of END and ENK. We found that (i) epidural bupivacaine, fentanyl and PCIA provided similar and clinically acceptable postoperative pain relief; (ii) compared to PCIA, epidural bupivacaine or fentanyl did not change the gross inflammatory reaction within the surgical wound; (iii) opioid-containing leukocytes were almost absent in normal subcutaneous tissue but migrated to the inflamed wound tissue in ascending numbers within a few hours, reaching a peak at about 24 h after surgery; (iv) compared to PCIA, EDA resulted in significantly decreased homing of END-containing leukocytes to the injured site at 24 h after surgery; and (v) the magnitude of this decrease was similar regardless of the epidural medication. These findings suggest that nociceptive but not sympathetic neurons are primarily involved in the attraction of opioid-containing leukocytes during early stages of inflammation.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bbi.2006.10.014" target="_blank" rel="noreferrer">10.1016/j.bbi.2006.10.014</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Adjuvants
Aged
Analgesia
Analgesics
Anesthesia
Anesthesia/immunology/pharmacology
Anesthetics
Backlog
beta-Endorphin/drug effects/immunology/metabolism
Biomarkers of Pain
Brain, Behavior, And Immunity
Bupivacaine/immunology/therapeutic use
Cell Movement/drug effects/immunology
Enkephalin
Epidural
Female
Fentanyl/immunology/therapeutic use
Heurich M
Humans
Journal Article
Kopf A
Lenzner M
Leukocytes/drug effects/immunology/metabolism
Local/immunology/therapeutic use
Longitudinal Studies
Male
Methionine/drug effects/immunology/metabolism
Middle Aged
Morciniec P
Mousa SA
Nociceptors/drug effects/immunology
Opioid/immunology/therapeutic use
Pain
Patient-Controlled
Pirinitramide/therapeutic use
Postganglionic/drug effects/immunology
Postoperative/immunology/prevention & control
Stein C
Subcutaneous Tissue/immunology
Sympathetic Fibers
Welte M
Wound Healing/drug effects/immunology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.cell.2010.09.047" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.cell.2010.09.047</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Genome-wide Drosophila Screen for Heat Nociception Identifies alpha2delta3 as an Evolutionarily Conserved Pain Gene
Publisher
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Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Biomarkers of Pain
Creator
An entity primarily responsible for making the resource
Neely GG; Hess A; Costigan M; Keene AC; Goulas S; Langeslag M; Griffin RS; Belfer I; Dai F; Smith SB; Diatchenko L; Gupta V; Xia CP; Amann S; Kreitz S; Heindl-Erdmann C; Wolz S; Ly CV; Arora S; Sarangi R; Dan D; Novatchkova M; Rosenzweig M; Gibson DG; Truong D; Schramek D; Zoranovic T; Cronin SJ; Angjeli B; Brune K; Dietzl G; Maixner W; Meixner A; Thomas W; Pospisilik JA; Alenius M; Kress M; Subramaniam S; Garrity PA; Bellen HJ; Woolf CJ; Penninger JM
Description
An account of the resource
Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the alpha2delta family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (alpha2delta3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, alpha2delta3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in alpha2delta3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in alpha2delta3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.
2010
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cell.2010.09.047" target="_blank" rel="noreferrer">10.1016/j.cell.2010.09.047</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2010
Alenius M
Amann S
Angjeli B
Arora S
Backlog
Belfer I
Bellen HJ
Biomarkers of Pain
Brune K
Cell
Costigan M
Cronin SJ
Dai F
Dan D
Diatchenko L
Dietzl G
Garrity PA
Gibson DG
Goulas S
Griffin RS
Gupta V
Heindl-Erdmann C
Hess A
Journal Article
Keene AC
Kreitz S
Kress M
Langeslag M
Ly CV
Maixner W
Meixner A
Neely GG
Novatchkova M
Penninger JM
Pospisilik JA
Rosenzweig M
Sarangi R
Schramek D
Smith SB
Subramaniam S
Thomas W
Truong D
Wolz S
Woolf CJ
Xia CP
Zoranovic T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.cpem.2007.06.006" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.cpem.2007.06.006</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pediatric End-of-Life Issues and Palliative Care
Publisher
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Clinical Pediatric Emergency Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Biomarkers of Pain
Creator
An entity primarily responsible for making the resource
Michelson KN; Steinhorn DM
Description
An account of the resource
Optimizing the quality of medical care at the end of life has achieved national status as an important health care goal. Palliative care, a comprehensive approach to treating the physical, psychosocial and spiritual needs of patients and their families facing life-limiting illnesses, requires the coordinated efforts of a multidisciplinary group of caregivers. Understanding the basic principles of palliative care can aid emergency department staff in identifying patients who could benefit from palliative care services and in managing the challenging situations that arise when such patients present to the hospital for care.In this article we present the overall philosophy of pediatric palliative care, describe key elements of quality palliative care, and identify additional referral sources readers can access for more information.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cpem.2007.06.006" target="_blank" rel="noreferrer">10.1016/j.cpem.2007.06.006</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Backlog
Biomarkers of Pain
Clinical Pediatric Emergency Medicine
Journal Article
Michelson KN
Steinhorn DM
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2008.10.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2008.10.013</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta-Endorphin Response to an Acute Pain Stimulus
Publisher
An entity responsible for making the resource available
Journal Of Neuroscience Methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
Subject
The topic of the resource
Male; Pain Measurement; Time Factors; Reproducibility of Results; Animals; Mice; Acute Disease; Biomarkers of Pain; Physical Stimulation; Animal; beta-Endorphin/analysis/metabolism/secretion; Biological Markers/analysis/blood; Disease Models; Inbred DBA; Neurochemistry/methods; Pain/blood/physiopathology; Radioimmunoassay/methods; Up-Regulation/physiology
Creator
An entity primarily responsible for making the resource
Rasmussen NA; Farr LA
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jneumeth.2008.10.013" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2008.10.013</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
The timing of the measurement of biological samples (e.g. biomarkers) is not always standardized. Biomarkers are the focus of many recent studies and treatments. The purpose of this study was to determine the timing of the release of beta-endorphin (BE), a possible biomarker, after exposure to pain and/or handling stress in order to standardize measurements. Mouse plasma was collected for BE analysis following handling i.e. being picked up by the investigator, exposure to a painful (55 degrees C hot-plate), or exposure to a nonpainful stimulus (room temperature hot-plate). The groups exposed to either a painful or nonpainful stimulus released BE in response to the stimulus, but the duration of the response was longer in mice exposed to a painful stimulus than in mice exposed to a nonpainful stimulus. The BE in the mice exposed to a nonpainful stimulus peaked at 1 min and returned to baseline levels by 5 min while the BE response of the mice exposed to a painful stimulus peaked at 10 min and remained elevated for 25 min. The results of this study indicate that BE can be a biomarker for pain and handling stress, however, the timing of the measurement should differ.
2009
Acute Disease
Animal
Animals
Backlog
beta-Endorphin/analysis/metabolism/secretion
Biological Markers/analysis/blood
Biomarkers of Pain
Disease Models
Farr LA
Inbred DBA
Journal Article
Journal Of Neuroscience Methods
Male
Mice
Neurochemistry/methods
Pain Measurement
Pain/blood/physiopathology
Physical Stimulation
Radioimmunoassay/methods
Rasmussen NA
Reproducibility of Results
Time Factors
Up-Regulation/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.jneuroim.2006.11.033" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jneuroim.2006.11.033</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo
Publisher
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Journal Of Neuroimmunology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Biomarkers of Pain; RNA; beta-Endorphin/metabolism; Freund's Adjuvant; Wistar; Lymphocytes/metabolism; Flow Cytometry/methods; Gene Expression Regulation/drug effects/physiology; Inflammation/chemically induced/complications/pathology; Messenger/metabolism; Pain/etiology/pathology; Pro-Opiomelanocortin/genetics/metabolism; Protein Sorting Signals; Reverse Transcriptase Polymerase Chain Reaction/methods
Creator
An entity primarily responsible for making the resource
Sitte N; Busch M; Mousa SA; Labuz D; Rittner H; Gore C; Krause H; Stein C; Schafer M
Description
An account of the resource
Proopiomelanocortin (POMC)-derived beta-endorphin1-31 (END) released from immune cells inhibits inflammatory pain. We examined the expression of END and POMC mRNA encoding the signal sequence required for entry of the nascent polypeptide into the regulated secretory pathway in lymphocytes of rats with inflamed hindpaws. Within 12 h of inflammation, END increased in popliteal lymph nodes and at 96 h the intraplantar neutralization of END exacerbated pain. Lymphocytes expressed POMC, END, and full-length POMC mRNA. Semi-nested PCR revealed 8-fold increased exon 2-3 spanning POMC mRNA. Thus, painful inflammation enhances signal sequence-encoding lymphocytic POMC mRNA needed for regulated secretion of functionally active END.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jneuroim.2006.11.033" target="_blank" rel="noreferrer">10.1016/j.jneuroim.2006.11.033</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Animals
Backlog
beta-Endorphin/metabolism
Biomarkers of Pain
Busch M
Flow Cytometry/methods
Freund's Adjuvant
Gene Expression Regulation/drug effects/physiology
Gore C
Inflammation/chemically induced/complications/pathology
Journal Article
Journal Of Neuroimmunology
Krause H
Labuz D
Lymphocytes/metabolism
Male
Messenger/metabolism
Mousa SA
Pain/etiology/pathology
Pro-Opiomelanocortin/genetics/metabolism
Protein Sorting Signals
Rats
Reverse Transcriptase Polymerase Chain Reaction/methods
Rittner H
RNA
Schafer M
Sitte N
Stein C
Time Factors
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.jpainsymman.2006.08.011" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jpainsymman.2006.08.011</a>
Dublin Core
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Title
A name given to the resource
Development of the paediatric pain profile: role of video analysis and saliva cortisol in validating a tool to assess pain in children with severe neurological disability
Publisher
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Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Child; Female; Humans; Male; Reproducibility of Results; Child Behavior; adolescent; Preschool; Biomarkers of Pain; Hydrocortisone/metabolism; Nervous System Diseases/complications/metabolism/psychology; Pain Measurement/methods; Pain/etiology/metabolism/psychology; Saliva/metabolism; Videotape Recording
Creator
An entity primarily responsible for making the resource
Hunt A; Wisbeach A; Seers K; Goldman A; Crichton N; Perry L; Mastroyannopoulou K
Description
An account of the resource
The Paediatric Pain Profile (PPP) is a 20-item behavior-rating scale designed to assess pain in children with severe to profound neurological impairment. Three raters independently used the PPP to rate behavior of 29 children (mean age 9.6, SD 5.8) filmed during everyday morning activities. The validation process included assessment of interrater reliability and exploration of the relationship of PPP scores with saliva cortisol concentration. There was substantial agreement between raters. The PPP showed strong association with global pain assessments and differentiated between preselected high- and low-pain groups. PPP score showed moderate correlation with saliva cortisol concentration, but a single child explained the strength of the relationship and overall, saliva cortisol concentrations appeared low. The data provide additional evidence that the PPP is a reliable and valid instrument for pain assessment in neurologically impaired children. Cortisol levels are not a useful criterion for pain in this population and further study of cortisol response to stress/pain in children with severe neurological impairments is needed.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jpainsymman.2006.08.011" target="_blank" rel="noreferrer">10.1016/j.jpainsymman.2006.08.011</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Adolescent
Backlog
Biomarkers of Pain
Child
Child Behavior
Crichton N
Female
Goldman A
Humans
Hunt A
Hydrocortisone/metabolism
Journal Article
Journal of Pain and Symptom Management
Male
Mastroyannopoulou K
Nervous System Diseases/complications/metabolism/psychology
Pain Measurement/methods
Pain/etiology/metabolism/psychology
Perry L
Preschool
Reproducibility of Results
Saliva/metabolism
Seers K
Videotape Recording
Wisbeach A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.npep.2007.06.001" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.npep.2007.06.001</a>
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Title
A name given to the resource
Targeting of opioid-producing leukocytes for pain control
Publisher
An entity responsible for making the resource available
Neuropeptides
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Biomarkers of Pain
Creator
An entity primarily responsible for making the resource
Machelska H
Description
An account of the resource
It is accepted that inflammatory mediators released from leukocytes contribute to the generation of pain. However, it is less well known that immune cells also produce mediators that can effectively counteract pain. These include anti-inflammatory cytokines and opioid peptides. This article concentrates on recent evidence that interactions between leukocyte-derived opioid peptides and their receptors on peripheral sensory neurons can result in potent, clinically relevant inhibition of pathological pain. Inflammation of peripheral tissues leads to increased synthesis and axonal transport of opioid receptors in dorsal root ganglion neurons. This results in opioid receptor upregulation and enhanced G-protein coupling at peripheral sensory nerve terminals. These events are dependent on neuronal electrical activity, production of proinflammatory cytokines and nerve growth factor within the inflamed tissue. Together with the disruption of the perineurial barrier, all these changes lead to an enhanced peripheral analgesic efficacy of opioids. The major source of local endogenous opioid ligands (beta-endorphin, enkephalins, endomorphins and dynorphin) are leukocytes. These cells contain and upregulate signal-sequence encoding mRNA of the beta-endorphin precursor proopiomelanocortin and the entire enzymatic machinery necessary for its processing into the functionally active peptide. Opioid-containing immune cells extravasate using adhesion molecules and chemokines to accumulate in inflamed tissues. Upon stressful stimuli or in response to releasing agents such as corticotropin-releasing factor, cytokines, chemokines and catecholamines, leukocytes secrete opioids. Depending on the cell type, this release is contingent on extracellular Ca(2+) or on inositol triphosphate receptor-triggered release of Ca(2+) from endoplasmic reticulum. Once secreted opioid peptides activate peripheral opioid receptors and produce analgesia by inhibiting the excitability of sensory nerves and/or the release of excitatory neuropeptides. These effects occur without central untoward side effects such as depression of breathing, clouding of consciousness or addiction. Future aims include the selective targeting of opioid-containing leukocytes to sites of painful injury and the augmentation of opioid peptide and receptor synthesis.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.npep.2007.06.001" target="_blank" rel="noreferrer">10.1016/j.npep.2007.06.001</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Backlog
Biomarkers of Pain
Journal Article
Machelska H
Neuropeptides
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.tvjl.2009.01.011" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.tvjl.2009.01.011</a>
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Title
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Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic
Publisher
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The Veterinary Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Biomarkers of Pain; Biomarkers Reference List
Creator
An entity primarily responsible for making the resource
Niinisto KE; Korolainen RV; Raekallio MR; Mykkanen AK; Koho NM; Ruohoniemi MO; Leppaluoto J; Poso AR
Description
An account of the resource
A prospective observational study was performed to evaluate whether the plasma concentration of heat shock protein 72 (HSP72) or β-endorphin is related to clinical signs, blood chemistry, or severity of pain of colic. Seventy-seven horses with colic and 15 clinically healthy controls were studied. The horses were divided into four groups which reflected increasing severity of colic, from normal control horses to horses with mild, moderate and severe colic. Blood samples were collected before any treatment. Packed cell volume (PCV) and plasma HSP72, β-endorphin, cortisol, adrenocorticotropic hormone (ACTH) and lactate concentrations were measured. Plasma β-endorphin was related with severity of colic and survival, as well as with plasma cortisol, ACTH and lactate concentrations, heart rate, PCV and pain score. High plasma HSP72 concentration may indicate circulatory deficits, but was not associated with clinical signs of colic. Plasma lactate still seemed to be the most useful single prognostic parameter in horses with colic.
2010-04
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.tvjl.2009.01.011" target="_blank" rel="noreferrer">10.1016/j.tvjl.2009.01.011</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2010
Backlog
Biomarkers of Pain
Biomarkers Reference List
Journal Article
Koho NM
Korolainen RV
Leppaluoto J
Mykkanen AK
Niinisto KE
Poso AR
Raekallio MR
Ruohoniemi MO
The Veterinary Journal
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1038/sj.npp.1301393" target="_blank" rel="noreferrer">http://doi.org/10.1038/sj.npp.1301393</a>
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Title
A name given to the resource
Inhibition of inflammatory pain by CRF at peripheral, spinal and supraspinal sites: involvement of areas coexpressing CRF receptors and opioid peptides
Publisher
An entity responsible for making the resource available
Neuropsychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Male; Pain Measurement; Animals; Rats; Biomarkers of Pain; Dose-Response Relationship; Drug; Receptors; Freund's Adjuvant; Wistar; Animal; Disease Models; Analgesics/administration & dosage; Drug Administration Routes; Pain Threshold/drug effects; Brain/drug effects/metabolism; Spinal Cord/drug effects/metabolism; Corticotropin-Releasing Hormone/administration & dosage; Opioid Peptides/metabolism; Corticotropin-Releasing Hormone/metabolism; Ganglia; Hormone Antagonists/administration & dosage; Inflammation/chemically induced/complications; Pain/drug therapy/etiology/pathology; Sciatic Nerve/pathology; Spinal/drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Mousa SA; Bopaiah CP; Richter JF; Yamdeu RS; Schafer M
Description
An account of the resource
There is conflicting evidence on the antinociceptive effects of corticotropin-releasing factor (CRF) along the neuraxis of pain transmission and the responsible anatomical sites of CRF's action at the level of the brain, spinal cord and periphery. In an animal model of tonic pain, that is, Freunds complete adjuvant (FCA) hindpaw inflammation, we systematically investigated CRF's ability to modulate inflammatory pain at those three levels of pain transmission by algesiometry following the intracerebroventricular, intrathecal, and intraplantar application of low, systemically inactive doses of CRF. At each level, CRF elicits potent antinociceptive effects, which are dose dependent and antagonized by local, but not systemic CRF receptor antagonist alpha-helical CRF indicating CRF receptor specificity. Consistently, we have identified by immunohistochemistry multiple brain areas, inhibitory interneurons within the dorsal horn of the spinal cord as well as immune cells within subcutaneous tissue--but not peripheral sensory neurons--that coexpress both CRF receptors and opioid peptides. In line with these anatomical findings, local administration of CRF together with the opioid receptor antagonist naloxone dose-dependently reversed CRF's antinociceptive effects at each of these three levels of pain transmission. Therefore, local application of low, systemically inactive doses of CRF at the level of the brain, spinal cord and periphery inhibits tonic inflammatory pain most likely through an activation of CRF receptors on cells that coexpress opioid peptides which results in opioid-mediated pain inhibition. Future studies have to delineate whether endogenous CRF at these three levels contributes to the body's response to cope with the stressful stimulus pain in an opioid-mediated manner.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/sj.npp.1301393" target="_blank" rel="noreferrer">10.1038/sj.npp.1301393</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Analgesics/administration & dosage
Animal
Animals
Backlog
Biomarkers of Pain
Bopaiah CP
Brain/drug effects/metabolism
Corticotropin-Releasing Hormone/administration & dosage
Corticotropin-Releasing Hormone/metabolism
Disease Models
Dose-Response Relationship
Drug
Drug Administration Routes
Freund's Adjuvant
Ganglia
Hormone Antagonists/administration & dosage
Inflammation/chemically induced/complications
Journal Article
Male
Mousa SA
Neuropsychopharmacology
Opioid Peptides/metabolism
Pain Measurement
Pain Threshold/drug effects
Pain/drug therapy/etiology/pathology
Rats
Receptors
Richter JF
Schafer M
Sciatic Nerve/pathology
Spinal Cord/drug effects/metabolism
Spinal/drug effects/metabolism
Wistar
Yamdeu RS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1055/s-0029-1243620" target="_blank" rel="noreferrer">http://doi.org/10.1055/s-0029-1243620</a>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serum Beta-Endorphin Response to Stress Before and After Operation Under Fentanyl Anesthesia in Neonates, Infants and Preschool Children
Publisher
An entity responsible for making the resource available
European Journal Of Pediatric Surgery
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Biomarkers of Pain
Creator
An entity primarily responsible for making the resource
Mirilas P; Mentessidou A; Kontis E; Antypa E; Makedou A; Petropoulos AS
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1055/s-0029-1243620" target="_blank" rel="noreferrer">10.1055/s-0029-1243620</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2010-04
2010
Antypa E
Backlog
Biomarkers of Pain
European Journal Of Pediatric Surgery
Journal Article
Kontis E
Makedou A
Mentessidou A
Mirilas P
Petropoulos AS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1089/jpm.2009.0265" target="_blank" rel="noreferrer">http://doi.org/10.1089/jpm.2009.0265</a>
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Title
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Pediatricians' management practices for chronic pain
Publisher
An entity responsible for making the resource available
Journal Of Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Biomarkers of Pain
Creator
An entity primarily responsible for making the resource
Thompson LA; Knapp CA; Feeg V; Madden VL; Shenkman EA
Description
An account of the resource
OBJECTIVE: While research has established that pediatric pain is undertreated, it is unclear who should have primary responsibility for its management. This study asks pediatricians who they believe should treat pain and how pain should be assessed and managed. METHODS: We administered a mail and online survey about pediatric chronic pain and palliative care to a random sample of 800 U.S. pediatricians, and performed descriptive and multivariate analyses on 303 respondents. RESULTS: Most pediatrician responders were white, non-Hispanic (55.8%), and had been in practice 10 or more years (68.0%). Only one third of pediatricians (32.3%) felt it was their primary responsibility to treat chronic pain; most believed pain specialists (58.1%), other specialists, (39.6%), or hospice providers (26.1%) should be responsible. For pain assessments, most report using parent (87.1%) or patient (84.2%) verbal reports and one half (49.5%) use pain diaries, although multivariate analyses showed that inpatient pediatricians were significantly less likely to use these modalities. Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) were commonly cited medications to usually or always treat pain (61.7% and 66.9%, respectively) and 19.3% report never or rarely prescribing intermittent opiates in their practice. Multivariate analyses showed that there were no consistent physician qualities that predicted the use of opiate prescriptions. CONCLUSIONS: Our findings illustrate that pediatricians' theoretical approaches to chronic pain management are more collaborative than independent. Future research must test if pediatricians could benefit from supplemental pain education, increased emphasis on clinical guidance, and an increased awareness of hospice to be included in the pain management team for children.
2010
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/jpm.2009.0265" target="_blank" rel="noreferrer">10.1089/jpm.2009.0265</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2010
Backlog
Biomarkers of Pain
Feeg V
Journal Article
Journal of Palliative Medicine
Knapp CA
Madden VL
Shenkman EA
Thompson LA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1093/annonc/mdq155" target="_blank" rel="noreferrer">http://doi.org/10.1093/annonc/mdq155</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Impact of setting of care on pain management in patients with cancer: a multicentre cross-sectional study
Publisher
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Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Biomarkers of Pain
Creator
An entity primarily responsible for making the resource
Sichetti D; Bandieri E; Romero M; Di Biagio K; Luppi M; Belfiglio M; Tognoni G; Ripamonti CI; Working Group for ECAD
Description
An account of the resource
BACKGROUND: No study has so far addressed whether differences do exist in the management of cancer-related pain in patients admitted to oncology and non-oncology settings. PATIENTS AND METHODS: A multicentre cross-sectional study in 48 Italian hospitals has enrolled 819 patients receiving analgesic therapy for cancer-related pain. Demographics and clinical and analgesic therapy information have been prospectively collected by standardized forms. Adequacy of pain management has been evaluated by the Pain Management Index (PMI). RESULTS: Differences in the analgesic drug administration according to settings of care have been evident, non-opioids more frequently being administered in non-oncology units (19.6% versus 7.0%; P < 0.0001), while strong opioids are more frequently used in the oncology units (69.5% versus 51.9%; P < 0.0001). The number of patients receiving inadequate therapy (PMI < 0) has lowered in oncology compared with non-oncology units (11.3% versus 18.8%; P = 0.0024). Results of multiple logistic regression analysis have shown that the admission to non-oncology setting [odds ratio (OR) = 1.75, 95% confidence interval (CI) = 1.15-2.67; P = 0.0096] and the absence of metastatic disease (OR = 1.60, 95% CI = 1.04-2.44; P = 0.0317) were independent factors associated with an increased risk of receiving an inadequate analgesic therapy. CONCLUSION: Oncology wards provide the most adequate standard of analgesic therapy for cancer-related pain.
2010
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/annonc/mdq155" target="_blank" rel="noreferrer">10.1093/annonc/mdq155</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2010
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo
Backlog
Bandieri E
Belfiglio M
Biomarkers of Pain
Di Biagio K
Journal Article
Luppi M
Ripamonti CI
Romero M
Sichetti D
Tognoni G
Working Group for ECAD
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/01.ta.0000222714.91463.a3" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.ta.0000222714.91463.a3</a>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma
Publisher
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The Journal Of Trauma
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Child; Female; Humans; Male; adolescent; Preschool; infant; beta-Endorphin/blood; Biomarkers of Pain; Biomarkers Reference List; Biological Markers/blood; Wounds; Hydrocortisone/blood; Extremities/injuries; Nonpenetrating/metabolism/surgery; Thoracic Injuries/metabolism/surgery; Trauma Severity Indices
Creator
An entity primarily responsible for making the resource
Okur H; Kucukaydn M; Ozokutan BH; Muhtaroglu S; Kazez A; Turan C
Description
An account of the resource
PURPOSE: To determine the levels of beta-endorphin and cortisol in children with multiple injuries and to determine whether there is any difference between and compare the severity of trauma and beta-endorphin and cortisol release as calculated using Pediatric Trauma Score (PTS). METHODS: During a 10-month period, 80 children with multiple injuries admitted to a University Hospital's Pediatric Surgery Department were studied. Blood samples were obtained immediately at admission and a PTS of each patient was calculated. The correlation between PTS and hormonal values were searched. The children were classified into two groups according to their PTS. Group 1 had PTS >8 and group 2 had PTS 0.05). The mean PTS for group 1 patients was 11 +/- 0.8 and for group 2 patients was 7.4 +/- 1.2 (p < 0.001). The mean plasma beta-endorphin concentrations were 124.4 +/- 114.4 pg/mL in group 1 patients and 261.6 +/- 231.2 pg/mL in group 2 (p < 0.001). The respective plasma cortisol concentrations in the two groups were 22.5 +/- 10.3 microg/dL and 30.8 +/- 17.2 microg/dL (p < 0.05), respectively. CONCLUSIONS: The results of this study show that the plasma beta-endorphin and cortisol levels are elevated in children after blunt trauma and the degree of elevation is related to the injury severity.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.ta.0000222714.91463.a3" target="_blank" rel="noreferrer">10.1097/01.ta.0000222714.91463.a3</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Adolescent
Backlog
beta-Endorphin/blood
Biological Markers/blood
Biomarkers of Pain
Biomarkers Reference List
Child
Extremities/injuries
Female
Humans
Hydrocortisone/blood
Infant
Journal Article
Kazez A
Kucukaydn M
Male
Muhtaroglu S
Nonpenetrating/metabolism/surgery
Okur H
Ozokutan BH
Preschool
The Journal Of Trauma
Thoracic Injuries/metabolism/surgery
Trauma Severity Indices
Turan C
Wounds
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1136/ard.2006.067066" target="_blank" rel="noreferrer">http://doi.org/10.1136/ard.2006.067066</a>
Dublin Core
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Title
A name given to the resource
Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis
Publisher
An entity responsible for making the resource available
Annals Of The Rheumatic Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Female; Humans; Male; Adult; Aged; Middle Aged; 80 and over; Arthritis; Biomarkers of Pain; Opioid; Receptors; Biological Markers/analysis; beta-Endorphin/analysis; Enkephalin; Methionine/analysis; Immunohistochemistry/methods; Arthritis/immunology/metabolism; delta/analysis; Joints/immunology/injuries; Leukocytes/immunology; mu/analysis; Opioid/analysis; Osteoarthritis/immunology/metabolism; Rheumatoid/immunology/metabolism; Synovial Membrane/chemistry/immunology
Creator
An entity primarily responsible for making the resource
Mousa SA; Straub RH; Schafer M; Stein C
Description
An account of the resource
OBJECTIVE: Intra-articularly applied opioid agonists or antagonists modulate pain after knee surgery and in chronic arthritis. Therefore, the expression of beta-endorphin (END), Met-enkephalin (ENK), and mu and delta opioid receptors (ORs) within synovium of patients with joint trauma (JT), osteoarthritis (OA) and rheumatoid arthritis (RA) were examined. METHODS: Synovial samples were subjected to double immunohistochemical analysis of opioid peptides with immune cell markers, and of ORs with the neuronal markers calcitonin gene-related peptide (CGRP) and tyrosine hydroxylase (TH). RESULTS: END and ENK were expressed by macrophage-like (CD68(+)) and fibroblast-like (CD68(-)) cells within synovial lining layers of all disorders. In the sublining layers, END and ENK were mostly expressed by granulocytes in patients with JT, and by macrophages/monocytes, lymphocytes and plasma cells in those with OA and RA. Overall, END- and ENK-immunoreactive (IR) cells were more abundant in patients with RA than in those with OA and JT. ORs were found on nerve fibres and immune cells in all patients. OR-IR nerve fibres were significantly more abundant in patients with RA than in those with OA and JT. muORs and deltaORs were coexpressed with CGRP but not with TH. CONCLUSIONS: Parallel to the severity of inflammation, END and ENK in immune cells and their receptors on sensory nerve terminals are more abundant in patients with RA than in those with JT and OA. These findings are consistent with the notion that, with prolonged and enhanced inflammation, the immune and peripheral nervous systems upregulate sensory nerves expressing ORs and their ligands to counterbalance pain and inflammation.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/ard.2006.067066" target="_blank" rel="noreferrer">10.1136/ard.2006.067066</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
80 And Over
Adult
Aged
Annals Of The Rheumatic Diseases
Arthritis
Arthritis/immunology/metabolism
Backlog
beta-Endorphin/analysis
Biological Markers/analysis
Biomarkers of Pain
delta/analysis
Enkephalin
Female
Humans
Immunohistochemistry/methods
Joints/immunology/injuries
Journal Article
Leukocytes/immunology
Male
Methionine/analysis
Middle Aged
Mousa SA
mu/analysis
Opioid
Opioid/analysis
Osteoarthritis/immunology/metabolism
Receptors
Rheumatoid/immunology/metabolism
Schafer M
Stein C
Straub RH
Synovial Membrane/chemistry/immunology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1371/journal.pone.0005289" target="_blank" rel="noreferrer">http://doi.org/10.1371/journal.pone.0005289</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pain reactivity and plasma beta-endorphin in children and adolescents with autistic disorder
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
Subject
The topic of the resource
Child; Female; Humans; Male; Case-Control Studies; adolescent; beta-Endorphin/blood; Biomarkers of Pain; Pain/physiopathology; Biomarkers Reference List; Autistic Disorder/blood/physiopathology
Creator
An entity primarily responsible for making the resource
Tordjman S; Anderson GM; Botbol M; Brailly-Tabard S; Perez-Diaz F; Graignic R; Carlier M; Schmit G; Rolland AC; Bonnot O; Trabado S; Roubertoux P; Bronsard G
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0005289" target="_blank" rel="noreferrer">10.1371/journal.pone.0005289</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
BACKGROUND: Reports of reduced pain sensitivity in autism have prompted opioid theories of autism and have practical care ramifications. Our objective was to examine behavioral and physiological pain responses, plasma beta-endorphin levels and their relationship in a large group of individuals with autism. METHODOLOGY/PRINCIPAL FINDINGS: The study was conducted on 73 children and adolescents with autism and 115 normal individuals matched for age, sex and pubertal stage. Behavioral pain reactivity of individuals with autism was assessed in three observational situations (parents at home, two caregivers at day-care, a nurse and child psychiatrist during blood drawing), and compared to controls during venepuncture. Plasma beta-endorphin concentrations were measured by radioimmunoassay. A high proportion of individuals with autism displayed absent or reduced behavioral pain reactivity at home (68.6%), at day-care (34.2%) and during venepuncture (55.6%). Despite their high rate of absent behavioral pain reactivity during venepuncture (41.3 vs. 8.7% of controls, P<0.0001), individuals with autism displayed a significantly increased heart rate in response to venepuncture (P<0.05). Moreover, this response (Delta heart rate) was significantly greater than for controls (mean+/-SEM; 6.4+/-2.5 vs. 1.3+/-0.8 beats/min, P<0.05). Plasma beta-endorphin levels were higher in the autistic group (P<0.001) and were positively associated with autism severity (P<0.001) and heart rate before or after venepuncture (P<0.05), but not with behavioral pain reactivity. CONCLUSIONS/SIGNIFICANCE: The greater heart rate response to venepuncture and the elevated plasma beta-endorphin found in individuals with autism reflect enhanced physiological and biological stress responses that are dissociated from observable emotional and behavioral reactions. The results suggest strongly that prior reports of reduced pain sensitivity in autism are related to a different mode of pain expression rather than to an insensitivity or endogenous analgesia, and do not support opioid theories of autism. Clinical care practice and hypotheses regarding underlying mechanisms need to assume that children with autism are sensitive to pain.
2009
Adolescent
Anderson GM
Autistic Disorder/blood/physiopathology
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Biomarkers Reference List
Bonnot O
Botbol M
Brailly-Tabard S
Bronsard G
Carlier M
Case-Control Studies
Child
Female
Graignic R
Humans
Journal Article
Male
Pain/physiopathology
Perez-Diaz F
PLoS One
Rolland AC
Roubertoux P
Schmit G
Tordjman S
Trabado S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/s11926-007-0081-3" target="_blank" rel="noreferrer">http://doi.org/10.1007/s11926-007-0081-3</a>
<a href="http://dx.doi.org/10.1007/s11926-007-0081-3" target="_blank" rel="noreferrer">http://dx.doi.org/10.1007/s11926-007-0081-3</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Leukocytes as mediators of pain and analgesia
Publisher
An entity responsible for making the resource available
Current Rheumatology Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Biomarkers of Pain
Creator
An entity primarily responsible for making the resource
Rittner
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11926-007-0081-3" target="_blank" rel="noreferrer">10.1007/s11926-007-0081-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2007
2007
Backlog
Biomarkers of Pain
Current Rheumatology Reports
Journal Article
Rittner
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.ejpain.2004.05.009" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.ejpain.2004.05.009</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia
Publisher
An entity responsible for making the resource available
European Journal Of Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; Analgesia; Biomarkers of Pain; Receptors; Pain/physiopathology; Cytokines/physiology; Opioid/physiology; Chemokines/physiology; Opioid Peptides/physiology; Pain Threshold/physiology
Creator
An entity primarily responsible for making the resource
Rittner HL; Stein C
Description
An account of the resource
Tissue destruction is accompanied by an inflammatory reaction. The inflammatory reaction leads to activation of nociceptors and the sensation of pain. Several mediators are responsible for pain and hyperalgesia in inflammation including cytokines, chemokines, nerve growth factor as well as bradykinin, prostaglandins and ATP. Simulatenously however, analgesic mediators are secreted: opioid peptides, somatostatin, endocannabinoids and certain cytokines. Opioid peptides secreted from immune cells are so far the best studied peptides in peripheral inflammatory pain control. This system is hampered for example by anti-adhesion molecule treatment. Novel immunosuppressive drugs for treatment of autoimmune disease targetting cytokines, chemokines or adhesion molecules should therefore be evaluated for potential harmful effects on pain.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejpain.2004.05.009" target="_blank" rel="noreferrer">10.1016/j.ejpain.2004.05.009</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Analgesia
Backlog
Biomarkers of Pain
Chemokines/physiology
Cytokines/physiology
European Journal Of Pain
Humans
Journal Article
Opioid Peptides/physiology
Opioid/physiology
Pain Threshold/physiology
Pain/physiopathology
Receptors
Rittner HL
Stein C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1073/pnas.0409888102" target="_blank" rel="noreferrer">http://doi.org/10.1073/pnas.0409888102</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
Publisher
An entity responsible for making the resource available
Proceedings Of The National Academy Of Sciences Of The United States Of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; Male; Animals; Rats; Biomarkers of Pain; Cells; Cultured; Analgesics/pharmacology; Sprague-Dawley; beta-Endorphin/secretion; Cannabinoid; Cannabinoids; CB2/agonists/physiology; Endothelin B/physiology; Receptor
Creator
An entity primarily responsible for making the resource
Ibrahim MM; Porreca F; Lai J; Albrecht PJ; Rice FL; Khodorova A; Davar G; Makriyannis A; Vanderah TW; Mata HP; Malan TP
Description
An account of the resource
CB(2) cannabinoid receptor-selective agonists are promising candidates for the treatment of pain. CB(2) receptor activation inhibits acute, inflammatory, and neuropathic pain responses but does not cause central nervous system (CNS) effects, consistent with the lack of CB(2) receptors in the normal CNS. To date, there has been virtually no information regarding the mechanism of CB(2) receptor-mediated inhibition of pain responses. Here, we test the hypothesis that CB(2) receptor activation stimulates release from keratinocytes of the endogenous opioid beta-endorphin, which then acts at opioid receptors on primary afferent neurons to inhibit nociception. The antinociceptive effects of the CB(2) receptor-selective agonist AM1241 were prevented in rats when naloxone or antiserum to beta-endorphin was injected in the hindpaw where the noxious thermal stimulus was applied, suggesting that beta-endorphin is necessary for CB(2) receptor-mediated antinociception. Further, AM1241 did not inhibit nociception in mu-opioid receptor-deficient mice. Hindpaw injection of beta-endorphin was sufficient to produce antinociception. AM1241 stimulated beta-endorphin release from rat skin tissue and from cultured human keratinocytes. This stimulation was prevented by AM630, a CB(2) cannabinoid receptor-selective antagonist and was not observed in skin from CB(2) cannabinoid receptor-deficient mice. These data suggest that CB(2) receptor activation stimulates release from keratinocytes of beta-endorphin, which acts at local neuronal mu-opioid receptors to inhibit nociception. Supporting this possibility, CB(2) immunolabeling was detected on beta-endorphin-containing keratinocytes in stratum granulosum throughout the epidermis of the hindpaw. This mechanism allows for the local release of beta-endorphin, where CB(2) receptors are present, leading to anatomical specificity of opioid effects.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1073/pnas.0409888102" target="_blank" rel="noreferrer">10.1073/pnas.0409888102</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Albrecht PJ
Analgesics/pharmacology
Animals
Backlog
beta-Endorphin/secretion
Biomarkers of Pain
Cannabinoid
Cannabinoids
CB2/agonists/physiology
Cells
Cultured
Davar G
Endothelin B/physiology
Humans
Ibrahim MM
Journal Article
Khodorova A
Lai J
Makriyannis A
Malan TP
Male
Mata HP
Porreca F
Proceedings Of The National Academy Of Sciences Of The United States Of America
Rats
Receptor
Rice FL
Sprague-Dawley
Vanderah TW
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1189/jlb.0405223" target="_blank" rel="noreferrer">http://doi.org/10.1189/jlb.0405223</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Leukocytes in the regulation of pain and analgesia
Publisher
An entity responsible for making the resource available
Journal Of Leukocyte Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; Analgesia; Animals; Biomarkers of Pain; Receptors; Biomarkers Reference List; Pain/immunology/physiopathology; Inflammation Mediators/immunology; Leukocytes/immunology/secretion; Nervous System/immunology/physiopathology; Neuropeptides/immunology/pharmacology; Opioid Peptides/immunology/secretion; Opioid/immunology; Sensory/immunology/physiopathology; Signal Transduction/immunology
Creator
An entity primarily responsible for making the resource
Rittner HL; Machelska H; Stein C
Description
An account of the resource
When tissue is destroyed or invaded by leukocytes in inflammation, numerous mediators are delivered by the circulation and/or liberated from resident and immigrated cells at the site. Proalgesic mediators include proinflammatory cytokines, chemokines, protons, nerve growth factor, and prostaglandins, which are produced by invading leukocytes or by resident cells. Less well known is that analgesic mediators, which counteract pain, are also produced in inflamed tissues. These include anti-inflammatory cytokines and opioid peptides. Interactions between leukocyte-derived opioid peptides and opioid receptors can lead to potent, clinically relevant inhibition of pain (analgesia). Opioid receptors are present on peripheral endings of sensory neurons. Opioid peptides are synthesized in circulating leukocytes, which migrate to inflamed tissues directed by chemokines and adhesion molecules. Under stressful conditions or in response to releasing agents (e.g., corticotropin-releasing factor, cytokines, noradrenaline), leukocytes can secrete opioids. They activate peripheral opioid receptors and produce analgesia by inhibiting the excitability of sensory nerves and/or the release of excitatory neuropeptides. This review presents discoveries that led to the concepts of pain generation by mediators secreted from leukocytes and of analgesia by immune-derived opioids.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1189/jlb.0405223" target="_blank" rel="noreferrer">10.1189/jlb.0405223</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Analgesia
Animals
Backlog
Biomarkers of Pain
Biomarkers Reference List
Humans
Inflammation Mediators/immunology
Journal Article
Journal Of Leukocyte Biology
Leukocytes/immunology/secretion
Machelska H
Nervous System/immunology/physiopathology
Neuropeptides/immunology/pharmacology
Opioid Peptides/immunology/secretion
Opioid/immunology
Pain/immunology/physiopathology
Receptors
Rittner HL
Sensory/immunology/physiopathology
Signal Transduction/immunology
Stein C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1196/annals.1376.022" target="_blank" rel="noreferrer">http://doi.org/10.1196/annals.1376.022</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stress and the adolescent brain
Publisher
An entity responsible for making the resource available
Annals Of The New York Academy Of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Subject
The topic of the resource
Humans; Stress; adolescent; Biomarkers of Pain; Brain/physiology; Hypothalamo-Hypophyseal System/physiology; Pituitary-Adrenal System/physiology; Psychological/physiopathology; Puberty/physiology
Creator
An entity primarily responsible for making the resource
Romeo RD; McEwen BS
Description
An account of the resource
During adolescence the brain shows remarkable changes in both structure and function. The plasticity exhibited by the brain during this pubertal period may make individuals more vulnerable to perturbations, such as stress. Although much is known about how exposure to stress and stress hormones during perinatal development and adulthood affect the structure and function of the brain, relatively little is known about how the pubertal brain responds to stress. Furthermore, it is not clear whether stressors experienced during adolescence lead to altered physiological and behavioral potentials in adulthood, as has been shown for perinatal development. The purpose of this review is to present what is currently known about the pubertal maturation of the hypothalamic-pituitary-adrenal (HPA) axis, the neuroendocrine axis that mediates the stress response, and discuss what is currently known about how stressors affect the adolescent brain. Our dearth of knowledge regarding the effects of stress on the pubertal brain will be discussed in the context of our accumulating knowledge regarding stress-induced neuronal remodeling in the adult. Finally, as the adolescent brain is capable of such profound plasticity during this developmental stage, we will also explore the possibility of adolescence as a period of interventions and opportunities to mitigate negative consequences from earlier developmental insults.
2006
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1376.022" target="_blank" rel="noreferrer">10.1196/annals.1376.022</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2006
Adolescent
Annals Of The New York Academy Of Sciences
Backlog
Biomarkers of Pain
Brain/physiology
Humans
Hypothalamo-Hypophyseal System/physiology
Journal Article
McEwen BS
Pituitary-Adrenal System/physiology
Psychological/physiopathology
Puberty/physiology
Romeo RD
Stress
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1001/archpedi.157.11.1071" target="_blank" rel="noreferrer">http://doi.org/10.1001/archpedi.157.11.1071</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta-endorphin concentration after administration of sucrose in preterm infants
Publisher
An entity responsible for making the resource available
Archives Of Pediatrics & Adolescent Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; infant; Male; Pain Measurement; Prospective Studies; Intensive Care; Administration; beta-Endorphin/blood; Biomarkers of Pain; Newborn; Oral; Pain/drug therapy/etiology; Premature; Sucrose/administration & dosage
Creator
An entity primarily responsible for making the resource
Taddio A; Shah V; Shah P; Katz J
Description
An account of the resource
BACKGROUND: Sucrose is an effective analgesic for procedural pain in preterm infants. It has been hypothesized that its analgesic effects are mediated by the release of endogenous opioid neurotransmitters such as beta-endorphin. OBJECTIVE: To determine whether intraoral administration of sucrose was associated with an increase in serum beta-endorphin concentrations in preterm infants with a gestation period less than 29 weeks who were not exposed to a painful stimulus. METHODS: We performed a prospective open-label study in preterm infants admitted to 2 tertiary neonatal intensive care units. Each infant received a single dose of 30% sucrose intraorally during a 1- to 2-minute period. A blood sample was obtained using an indwelling arterial catheter to determine beta-endorphin concentration immediately before and 2 to 5 minutes after the commencement of sucrose administration. RESULTS: We enrolled 11 preterm infants with a mean +/- SD gestational age of 27.2 +/- 0.9 weeks and a mean +/- SD birth weight of 1018 +/- 238 g (1.02 +/- 0.24 kg) at a mean +/- SD postnatal age of 3.0 +/- 2.5 days. The mean +/- SD beta-endorphin concentration before and after sucrose administration was 60.4 +/- 30.5 pg/mL and 57.4 +/- 22.4 pg/mL, respectively (P =.45). No adverse events were observed during the study procedures. CONCLUSION: Intraoral administration of sucrose in preterm infants did not lead to an increase in serum beta-endorphin concentrations at a point in time when the analgesic effects of sucrose were presumed to be present.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/archpedi.157.11.1071" target="_blank" rel="noreferrer">10.1001/archpedi.157.11.1071</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Administration
Archives Of Pediatrics & Adolescent Medicine
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Female
Humans
Infant
Intensive Care
Journal Article
Katz J
Male
Newborn
Oral
Pain Measurement
Pain/drug therapy/etiology
Premature
Prospective Studies
Shah P
Shah V
Sucrose/administration & dosage
Taddio A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0024-3205(02)02415-3" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0024-3205(02)02415-3</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cytokine and hormone profiles in mice subjected to handling combined with rectal temperature measurement stress and handling only stress
Publisher
An entity responsible for making the resource available
Life Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Animals; Mice; Stress; beta-Endorphin/blood; Biomarkers of Pain; RNA; Killer Cells; Body Temperature/physiology; Adrenocorticotropic Hormone/blood; Cytokines/blood/metabolism; Handling (Psychology); Hormones/blood/metabolism; Inbred BALB C; Messenger/biosynthesis; Natural/physiology; Psychological/metabolism; Spleen/cytology/metabolism
Creator
An entity primarily responsible for making the resource
Hale KD; Weigent DA; Gauthier DK; Hiramoto RN; Ghanta VK
Description
An account of the resource
Stress is known to either up or down regulate immunity. In this study, mice were subjected to handling combined with rectal temperature measurement (RTM) stress or handling only stress. We investigated whether there were any significant differences in the effect of handling combined with RTM and handling only on NK cell activity, serum cytokine (IL-1beta, IL-6, and TNF-alpha) and ACTH and beta-endorphin levels, and splenic cytokine (IL-1beta, IL-6, TNF-alpha, IFN-alpha, and IFN-beta) levels. Circulating cytokines and hormones and splenic cytokine mRNA levels were measured in individual mice. NK cell activity was significantly increased in both stress groups when compared to the control group. Handling combined with RTM produced significantly increased serum levels of IL-1beta, IL-6, and beta-endorphin. Serum IL-1beta, ACTH, and beta-endorphin were elevated significantly in the handling only group. Splenic TNFalpha mRNA in both of the stress groups and IL-6 mRNA in handling only group decreased significantly. Our observations are supported by existing literature demonstrating that various stressors have differential effects on immune functions and the neuroendocrine hormones and cytokines, which regulate them.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0024-3205(02)02415-3" target="_blank" rel="noreferrer">10.1016/s0024-3205(02)02415-3</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adrenocorticotropic Hormone/blood
Animals
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Body Temperature/physiology
Cytokines/blood/metabolism
Female
Gauthier DK
Ghanta VK
Hale KD
Handling (Psychology)
Hiramoto RN
Hormones/blood/metabolism
Inbred BALB C
Journal Article
Killer Cells
Life Sciences
Messenger/biosynthesis
Mice
Natural/physiology
Psychological/metabolism
RNA
Spleen/cytology/metabolism
Stress
Weigent DA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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Backlog
URL Address
<a href="http://doi.org/10.1016/s0165-5728(02)00049-8" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0165-5728(02)00049-8</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain
Publisher
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Journal Of Neuroimmunology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Male; Animals; Rats; Biomarkers of Pain; Immunohistochemistry; Freund's Adjuvant; Hindlimb; Wistar; Lymph Nodes/cytology; Lymphocytes/chemistry; Macrophages/chemistry; Monocytes/chemistry; Oligopeptides/analysis; Pain/chemically induced/immunology; Posterior Horn Cells/chemistry; Skin/chemistry/immunology/innervation
Creator
An entity primarily responsible for making the resource
Mousa SA; Machelska H; Schafer M; Stein C
Description
An account of the resource
Recently, two novel highly selective mu-opioid receptor (MOR) agonists, endomorphin-1 and endomorphin-2, have been isolated from bovine as well as human brains and were proposed to be the endogenous ligand for MOR. Later, endomorphin-1 and endomorphin-2 have been detected in the immune system of rats and humans using radioimmunoassay in combination with reverse-high-phase-liquid chromatography. In the present study, we analyzed the expression of endomorphin-1, endomorphin-2 and MOR by immunohistochemistry in a model of Freund's complete adjuvant (FCA)-induced painful inflammation. While MOR was upregulated on peripheral and central nerve terminals, inflammation did not alter endomorphin-2 expression in nerve fibers either in the dorsal horn of the spinal cord or in subcutaneous tissue. Endomorphin-1 and endomorphin-2 were expressed in immune cells (macrophage/monocytes) in the medullary region of the popliteal lymph nodes. The proportion of immunocytes (macrophage/monocytes, lymphocytes) containing endomorphin-1 and endomorphin-2 was increased in inflamed lymph nodes and subcutaneous paw tissue of animals with local inflammatory pain. Taken together, the upregulation of MOR and of its endogenous ligands endomorphin-1 and endomorphin-2 in immunocytes suggests an involvement of these opioid peptides in the peripheral control of inflammatory pain.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-5728(02)00049-8" target="_blank" rel="noreferrer">10.1016/s0165-5728(02)00049-8</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Animals
Backlog
Biomarkers of Pain
Freund's Adjuvant
Hindlimb
Immunohistochemistry
Journal Article
Journal Of Neuroimmunology
Lymph Nodes/cytology
Lymphocytes/chemistry
Machelska H
Macrophages/chemistry
Male
Monocytes/chemistry
Mousa SA
Oligopeptides/analysis
Pain/chemically induced/immunology
Posterior Horn Cells/chemistry
Rats
Schafer M
Skin/chemistry/immunology/innervation
Stein C
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0165-5728(03)00213-3" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0165-5728(03)00213-3</a>
Dublin Core
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Title
A name given to the resource
Different mechanisms of intrinsic pain inhibition in early and late inflammation
Publisher
An entity responsible for making the resource available
Journal Of Neuroimmunology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Male; Time Factors; Pain Threshold; Animals; Rats; Biomarkers of Pain; Injections; Subcutaneous; Enkephalin; Hindlimb; Wistar; Corticotropin-Releasing Hormone/administration & dosage; Dynorphins/antagonists & inhibitors/biosynthesis/physiology; Edema/immunology/metabolism/physiopathology; Endorphins/antagonists & inhibitors/biosynthesis/physiology; Freund's Adjuvant/administration & dosage; Inflammation/immunology/metabolism/physiopathology; Leukocytes/drug effects/metabolism/physiology; Methionine/antagonists & inhibitors/biosynthesis/physiology; Naloxone/administration & dosage; Pain/immunology/pathology/prevention & control; Stress/immunology/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Machelska H; Schopohl JK; Mousa SA; Labuz D; Schafer M; Stein C
Description
An account of the resource
Neuroimmune interactions control pain through activation of opioid receptors on sensory nerves by immune-derived opioid peptides. Here we evaluate mechanisms of intrinsic pain inhibition at different stages of Freund's adjuvant-induced inflammation of the rat paw. We use immunohistochemistry and paw pressure testing. Our data show that in early (6 h) inflammation leukocyte-derived beta-endorphin, met-enkephalin and dynorphin A activate peripheral mu-, delta- and kappa-receptors to inhibit nociception. In addition, central opioid mechanisms seem to contribute significantly to this effect. At later stages (4 days), antinociception is exclusively produced by leukocyte-derived beta-endorphin acting at peripheral mu and delta receptors. Corticotropin-releasing hormone (CRH) is an endogenous trigger of these effects at both stages. These findings indicate that peripheral opioid mechanisms of pain inhibition gain functional relevance with the chronicity of inflammation.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-5728(03)00213-3" target="_blank" rel="noreferrer">10.1016/s0165-5728(03)00213-3</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Animals
Backlog
Biomarkers of Pain
Corticotropin-Releasing Hormone/administration & dosage
Dynorphins/antagonists & inhibitors/biosynthesis/physiology
Edema/immunology/metabolism/physiopathology
Endorphins/antagonists & inhibitors/biosynthesis/physiology
Enkephalin
Freund's Adjuvant/administration & dosage
Hindlimb
Inflammation/immunology/metabolism/physiopathology
Injections
Journal Article
Journal Of Neuroimmunology
Labuz D
Leukocytes/drug effects/metabolism/physiology
Machelska H
Male
Methionine/antagonists & inhibitors/biosynthesis/physiology
Mousa SA
Naloxone/administration & dosage
Pain Threshold
Pain/immunology/pathology/prevention & control
Rats
Schafer M
Schopohl JK
Stein C
Stress/immunology/metabolism/physiopathology
Subcutaneous
Time Factors
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/S1090-3801(02)00143-X" target="_blank" rel="noreferrer">http://doi.org/10.1016/S1090-3801(02)00143-X</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Recommendations for using opioids in chronic non-cancer pain
Publisher
An entity responsible for making the resource available
European Journal Of Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Analgesics; Drug Administration Schedule; Psychology; Chronic disease; Biomarkers of Pain; Pain/drug therapy; Quality of Life/psychology; Opioid/therapeutic use; Patient Education
Creator
An entity primarily responsible for making the resource
Kalso E; Allan L; Dellemijn PL; Faura CC; Ilias WK; Jensen TS; Perrot S; Plaghki LH; Zenz M
Description
An account of the resource
1. The management of chronic pain should be directed by the underlying cause of the pain. Whatever the cause, the primary goal of patient care should be symptom control. 2. Opioid treatment should be considered for both continuous neuropathic and nociceptive pain if other reasonable therapies fail to provide adequate analgesia within a reasonable timeframe. 3. The aim of opioid treatment is to relieve pain and improve the patient's quality of life. Both of these should be assessed during a trial period. 4. The prescribing physician should be familiar with the patient's psychosocial status. 5. The use of sustained-release opioids administered at regular intervals is recommended. 6. Treatment should be monitored. 7. A contract setting out the patient's rights and responsibilities may help to emphasize the importance of patient involvement. 8. Opioid treatment should not be considered a lifelong treatment.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/S1090-3801(02)00143-X" target="_blank" rel="noreferrer">10.1016/S1090-3801(02)00143-X</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Allan L
Analgesics
Backlog
Biomarkers of Pain
Chronic Disease
Dellemijn PL
Drug Administration Schedule
European Journal Of Pain
Faura CC
Humans
Ilias WK
Jensen TS
Journal Article
Kalso E
Opioid/therapeutic use
Pain/drug Therapy
Patient Education
Perrot S
Plaghki LH
Psychology
Quality Of Life/psychology
Zenz M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">http://doi.org/10.1021/bi0300635</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Human neutrophils as a source of nociceptin: a novel link between pain and inflammation
Publisher
An entity responsible for making the resource available
Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Molecular Sequence Data; Biomarkers of Pain; Receptors; Neutrophils/metabolism; Arthritis/metabolism; Cyclic AMP/metabolism; Inflammation/metabolism; Opioid Peptides/metabolism; Opioid/agonists/genetics/metabolism; Pain/metabolism; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins/metabolism; Synovial Fluid/chemistry/immunology
Creator
An entity primarily responsible for making the resource
Fiset ME; Gilbert C; Poubelle PE; Pouliot M
Description
An account of the resource
Nociceptin is a neuropeptide sharing sequence homology with classical opioid peptides but with a distinct pharmacological profile. Through activation of its receptor, NociR, nociceptin has been linked with several physiological functions in the central nervous system including memory, locomotion, and processing of pain signals. Recently, peripheral blood neutrophils (PMNs) were demonstrated to express a functional NociR, a result suggesting that additional functions of the neuropeptide remain to be elucidated. The present study investigated the possibility that PMNs may be a source of nociceptin and whether the neuropeptide elicits PMN early responses. We observed the presence of nociceptin in the synovial fluids from arthritic patients, an inflammatory milieu typically containing high numbers of PMNs. In addition, freshly isolated PMNs were found to express and secrete nociceptin following degranulation, identifying these inflammatory cells as a novel source of the neuropeptide. Incubation of PMNs with nociceptin elicited a specific pattern of cellular protein phosphorylation on tyrosine residues in a rapid and transient fashion. Moreover, nociceptin prevented intracellular accumulation of cAMP in fMLP-stimulated PMNs, an effect mimicked by the specific NociR synthetic agonist, Ro 64-6198. Taken together, these results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">10.1021/bi0300635</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Arthritis/metabolism
Backlog
Biochemistry
Biomarkers of Pain
Cyclic AMP/metabolism
Fiset ME
Gilbert C
Humans
Inflammation/metabolism
Journal Article
Molecular Sequence Data
Neutrophils/metabolism
Opioid Peptides/metabolism
Opioid/agonists/genetics/metabolism
Pain/metabolism
Phosphorylation
Poubelle PE
Pouliot M
Protein-Tyrosine Kinases/metabolism
Proto-Oncogene Proteins c-hck
Proto-Oncogene Proteins/metabolism
Receptors
Synovial Fluid/chemistry/immunology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1089/152308604773934378" target="_blank" rel="noreferrer">http://doi.org/10.1089/152308604773934378</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Nitric oxide as a prognostic marker for neurological diseases
Publisher
An entity responsible for making the resource available
Antioxidants & Redox Signaling
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Humans; Adult; Prognosis; Animals; Biomarkers of Pain; Brain/pathology; Children W/SNI; Brain Neoplasms/cerebrospinal fluid/diagnosis; Cerebrospinal Fluid; Craniocerebral Trauma/cerebrospinal fluid/diagnosis; Electron Spin Resonance Spectroscopy/methods; Meningitis/cerebrospinal fluid/diagnosis; Nervous System Diseases/cerebrospinal fluid/diagnosis/mortality; Nitric Oxide/cerebrospinal fluid/metabolism
Creator
An entity primarily responsible for making the resource
Bratasz A; Kuter I; Konior R; Goscinski I; Lukiewicz S
Description
An account of the resource
The potential value of the nitric oxide (NO) level as a prognostic marker in human brain diseases is investigated. Cerebrospinal fluid (CSF) collected from neurological patients was examined for NO content using electron paramagnetic resonance (EPR) spectroscopy. In adult patients with meningitis, the level of NO was higher than that in other groups of brain disorders, such as brain traumas and brain tumors. Very high levels of NO in the CSF appeared to be correlated with a high incidence of fatal outcomes. In children with meningitis, it was possible to differentiate between viral and bacterial origin of the disease as evidenced by the EPR analysis of the CSF. The results indicated that NO levels in the CSF can be a useful prognostic marker in neurological diseases.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/152308604773934378" target="_blank" rel="noreferrer">10.1089/152308604773934378</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adult
Animals
Antioxidants & Redox Signaling
Backlog
Biomarkers of Pain
Brain Neoplasms/cerebrospinal fluid/diagnosis
Brain/pathology
Bratasz A
Cerebrospinal Fluid
Child
Children W/SNI
Craniocerebral Trauma/cerebrospinal fluid/diagnosis
Electron Spin Resonance Spectroscopy/methods
Goscinski I
Humans
Journal Article
Konior R
Kuter I
Lukiewicz S
Meningitis/cerebrospinal fluid/diagnosis
Nervous System Diseases/cerebrospinal fluid/diagnosis/mortality
Nitric Oxide/cerebrospinal fluid/metabolism
Prognosis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1093/bja/aeh222" target="_blank" rel="noreferrer">http://doi.org/10.1093/bja/aeh222</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia
Publisher
An entity responsible for making the resource available
British Journal Of Anaesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Female; Humans; Male; Adult; Analgesics; Aged; Middle Aged; Drug Therapy; Double-Blind Method; Biomarkers of Pain; Injections; Dose-Response Relationship; Drug; Opioid/administration & dosage; Receptors; Arthroscopy; Intra-Articular; Morphine/administration & dosage; Pain Measurement/methods; Combination; Knee Joint/metabolism/surgery; Opioid/metabolism; Pirinitramide/administration & dosage; Synovitis/metabolism/pathology
Creator
An entity primarily responsible for making the resource
Likar R; Mousa SA; Philippitsch G; Steinkellner H; Koppert W; Stein C; Schafer M
Description
An account of the resource
BACKGROUND: Both locally expressed beta-endorphin (END) and low doses of morphine relieve pain within inflamed knee joints. Here we examined whether enhanced inflammation and END expression within the synovial tissue of patients undergoing arthroscopic knee surgery might shift the analgesic dose-response curve of intra-articular (i.a.) morphine. METHODS: Following IRB approval and informed consent, patients were randomly assigned to the following i.a. treatments at the end of surgery: group I (n=39), isotonic saline; group II (n=40), 1 mg morphine hydrochloride; group III (n=48), 2 mg morphine hydrochloride; group IV (n=39), 4 mg morphine hydrochloride. Postoperative pain intensity was assessed by the visual analogue scale (VAS), by the time to first analgesic request and by the supplemental piritramide consumption. Synovial specimens from each patient were stained for the presence of inflammatory cells and END and were discriminated into groups with low versus high numbers of these cells. Differences between groups were statistically analyzed by chi(2), anova and mancova where appropiate. RESULTS: Patient characteristics and VAS scores did not differ between groups. Total postoperative piritramide consumption decreased and the time to first analgesic request increased significantly with increasing doses of i.a. morphine (P0.05, mancova). CONCLUSIONS: The dose-response relationship of i.a. morphine analgesia is not shifted by enhanced inflammation and END expression within synovial tissue. Thus, the presence of END within inflamed synovial tissue does not seem to interfere with i.a. morphine analgesia.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/bja/aeh222" target="_blank" rel="noreferrer">10.1093/bja/aeh222</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adult
Aged
Analgesics
Arthroscopy
Backlog
Biomarkers of Pain
British Journal Of Anaesthesia
Combination
Dose-Response Relationship
Double-Blind Method
Drug
Drug Therapy
Female
Humans
Injections
Intra-Articular
Journal Article
Knee Joint/metabolism/surgery
Koppert W
Likar R
Male
Middle Aged
Morphine/administration & dosage
Mousa SA
Opioid/administration & dosage
Opioid/metabolism
Pain Measurement/methods
Philippitsch G
Pirinitramide/administration & dosage
Receptors
Schafer M
Stein C
Steinkellner H
Synovitis/metabolism/pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/00000542-200401000-00024" target="_blank" rel="noreferrer">http://doi.org/10.1097/00000542-200401000-00024</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain
Publisher
An entity responsible for making the resource available
Anesthesiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Male; Animals; Rats; Biomarkers of Pain; Inflammation/complications; RNA; Pain Measurement/drug effects; Radioimmunoassay; Pain/drug therapy/physiopathology; Wistar; Neutrophils/metabolism; Messenger/biosynthesis; DNA Primers; Reverse Transcriptase Polymerase Chain Reaction; Flow Cytometry; Cell Adhesion Molecules/pharmacology; Cell Separation; Chemokines/biosynthesis; Chemotaxis; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Hindlimb/physiology; Leukocyte/drug effects; Light; Narcotics/metabolism/pharmacology; Stem Cell Factor/pharmacology
Creator
An entity primarily responsible for making the resource
Brack A; Rittner HL; Machelska H; Beschmann K; Sitte N; Schafer M; Stein C
Description
An account of the resource
BACKGROUND: Leukocytes can control inflammatory pain by secretion of opioid peptides, stimulated by cold-water swimming or local injection of corticotropin-releasing factor, and subsequent activation of opioid receptors on peripheral sensory neurons. This study investigated whether mobilization of polymorphonuclear cells (PMN) by granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) enhances immigration of opioid-containing PMN and peripheral opioid analgesia in rats with Freund complete adjuvant-induced hind paw inflammation. METHODS: In circulating PMN of rats treated with G-CSF+SCF and sham-treated rats, opioid peptide content was measured by radioimmunoassay. Expression of adhesion molecules (CD62L, CD49d, CD18), in vitro migration in the Boyden chamber, and infiltrating leukocytes were analyzed by flow cytometry. Chemokine messenger RNA transcription was quantified by LightCycler polymerase chain reaction. Paw pressure threshold was measured at baseline, after cold-water swimming, and after injection of corticotropin-releasing factor. RESULTS: G-CSF+SCF treatment increased circulating PMN (11-fold, P 0.05). CONCLUSIONS: G-CSF+SCF mobilized circulating opioid-containing PMN but had a minor influence on cell migration and peripheral analgesia, probably because of the low expression of chemokines in the inflamed paw and one of the decreased beta-endorphin content in PMN.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00000542-200401000-00024" target="_blank" rel="noreferrer">10.1097/00000542-200401000-00024</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Anesthesiology
Animals
Backlog
Beschmann K
Biomarkers of Pain
Brack A
Cell Adhesion Molecules/pharmacology
Cell Separation
Chemokines/biosynthesis
Chemotaxis
DNA Primers
Flow Cytometry
Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
Hindlimb/physiology
Inflammation/complications
Journal Article
Leukocyte/drug effects
Light
Machelska H
Male
Messenger/biosynthesis
Narcotics/metabolism/pharmacology
Neutrophils/metabolism
Pain Measurement/drug effects
Pain/drug therapy/physiopathology
Radioimmunoassay
Rats
Reverse Transcriptase Polymerase Chain Reaction
Rittner HL
RNA
Schafer M
Sitte N
Stein C
Stem Cell Factor/pharmacology
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/00000542-200407000-00031" target="_blank" rel="noreferrer">http://doi.org/10.1097/00000542-200407000-00031</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception
Publisher
An entity responsible for making the resource available
Anesthesiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Male; Analgesics; Animals; Rats; Biomarkers of Pain; Injections; Pain Measurement/drug effects; Freund's Adjuvant; Wistar; Flow Cytometry; Foot/pathology; Opioid/administration & dosage/pharmacology; Clodronic Acid/pharmacokinetics/pharmacology; Fentanyl/administration & dosage/pharmacology; Heat; Hyperalgesia/chemically induced/pathology/psychology; Inflammation/chemically induced/pathology; Liposomes; Macrophages/pathology; Monocytes/pathology; Non-Narcotic/pharmacokinetics/pharmacology; Pressure
Creator
An entity primarily responsible for making the resource
Brack A; Labuz D; Schiltz A; Rittner HL; Machelska H; Schafer M; Reszka R; Stein C
Description
An account of the resource
BACKGROUND: Opioid-containing leukocytes migrate to peripheral sites of inflammation. On exposure to stress, opioid peptides are released, bind to opioid receptors on peripheral sensory neurons, and induce endogenous antinociception. In later stages of Freund's complete adjuvant-induced local inflammation, monocytes/macrophages are a major opioid-containing leukocyte subpopulation, but these cells also produce proalgesic cytokines. In this study, the role of tissue monocytes/macrophages in hyperalgesia and in peripheral opioid-mediated antinociception was investigated. METHODS: After intraplantar injection of Freund's adjuvant, leukocyte subpopulations and opioid-containing leukocytes were analyzed by flow cytometry in the inflamed paw in the presence or absence of monocyte/macrophage depletion by intraplantar injection of clodronate-containing liposomes (phosphate-buffered saline and empty liposomes served as controls). Paw volume was measured with a plethysmometer. Hyperalgesia was determined by measuring heat-induced paw withdrawal latency and paw pressure threshold. Paw pressure threshold was also measured after swim stress and injection of fentanyl. RESULTS: At 48 and 96 h of inflammation, it was found that (1). monocytes/macrophages were the largest leukocyte subpopulation (> 55% of all leukocytes) and the predominant producers of opioid peptides (71-77% of all opioid-containing leukocytes in the paw), (2). clodronate-containing liposomes depleted monocytes/macrophages by 30-35% (P 0.05), and (4) opioid-containing leukocytes and swim stress but not fentanyl-induced antinociception were significantly decreased by clodronate-containing liposomes (P 0.05, all by t test; opioid-containing cells and swim stress-induced increase of paw pressure threshold were reduced by 35-42% and 20%, respectively). CONCLUSION: Partial depletion of tissue monocytes/macrophages impairs peripheral endogenous opioid-mediated antinociception without affecting hyperalgesia.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00000542-200407000-00031" target="_blank" rel="noreferrer">10.1097/00000542-200407000-00031</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Analgesics
Anesthesiology
Animals
Backlog
Biomarkers of Pain
Brack A
Clodronic Acid/pharmacokinetics/pharmacology
Fentanyl/administration & dosage/pharmacology
Flow Cytometry
Foot/pathology
Freund's Adjuvant
Heat
Hyperalgesia/chemically induced/pathology/psychology
Inflammation/chemically induced/pathology
Injections
Journal Article
Labuz D
Liposomes
Machelska H
Macrophages/pathology
Male
Monocytes/pathology
Non-Narcotic/pharmacokinetics/pharmacology
Opioid/administration & dosage/pharmacology
Pain Measurement/drug effects
Pressure
Rats
Reszka R
Rittner HL
Schafer M
Schiltz A
Stein C
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/00002508-200207000-00008" target="_blank" rel="noreferrer">http://doi.org/10.1097/00002508-200207000-00008</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report
Publisher
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The Clinical Journal Of Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Female; Humans; Male; Adult; Sensitivity and Specificity; Reproducibility of Results; Biomarkers of Pain; Diagnosis; Differential; Leukocytes; Mononuclear/immunology/metabolism; Fatigue Syndrome; beta-Endorphin/blood/immunology/metabolism; Chronic/blood/diagnosis/immunology; Depression/blood/diagnosis; Fibromyalgia/blood/diagnosis/immunology
Creator
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Panerai AE; Vecchiet J; Panzeri P; Meroni P; Scarone S; Pizzigallo E; Giamberardino MA; Sacerdote P
Description
An account of the resource
OBJECTIVE: The aim of this study was to examine the possible role of the immune system in the pathophysiology of chronic fatigue syndrome and fibromyalgia syndrome and in the differential diagnosis of depression by investigating changes in peripheral blood mononuclear cell levels of beta-endorphin, an endogenous opioid known to be involved in regulation of the immune system function. DESIGN: Beta-endorphin concentrations were measured by radioimmunoassay in peripheral blood mononuclear cells from healthy controls (n = 8) and patients with chronic fatigue syndrome (n = 17), fibromyalgia syndrome (n = 5), or depression (n = 10). RESULTS: Beta-endorphin concentrations were significantly lower in patients with chronic fatigue syndrome or fibromyalgia syndrome than in normal subjects and depressed patients (p <0.001 and p <0.01, respectively). They were significantly higher in depressed patients than in controls (p <0.01). CONCLUSIONS: Evaluation of peripheral blood mononuclear cell beta-endorphin concentrations could represent a diagnostic tool for chronic fatigue syndrome and fibromyalgia and help with differential diagnosis of these syndromes versus depression. The results obtained are also consistent with the hypothesis that the immune system is activated in both chronic fatigue syndrome and fibromyalgia syndrome.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00002508-200207000-00008" target="_blank" rel="noreferrer">10.1097/00002508-200207000-00008</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adult
Backlog
beta-Endorphin/blood/immunology/metabolism
Biomarkers of Pain
Chronic/blood/diagnosis/immunology
Depression/blood/diagnosis
Diagnosis
Differential
Fatigue Syndrome
Female
Fibromyalgia/blood/diagnosis/immunology
Giamberardino MA
Humans
Journal Article
Leukocytes
Male
Meroni P
Mononuclear/immunology/metabolism
Panerai AE
Panzeri P
Pizzigallo E
Reproducibility of Results
Sacerdote P
Scarone S
Sensitivity and Specificity
The Clinical Journal Of Pain
Vecchiet J
-
Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/01.ALC.0000095636.44770.55" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.ALC.0000095636.44770.55</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Decreased proopiomelanocortin mRNA in lymphocytes of chronic alcoholics after intravenous human corticotropin releasing factor injection
Publisher
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Alcoholism, Clinical And Experimental Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; Male; Adult; Aged; Middle Aged; Biomarkers of Pain; Nonparametric; Statistics; RNA; Corticotropin-Releasing Hormone/pharmacology; Alcoholism/blood/metabolism; Lymphocytes/drug effects/metabolism; Messenger/biosynthesis/genetics; Pro-Opiomelanocortin/biosynthesis/genetics
Creator
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Rosenberger P; Muhlbauer E; Weissmuller T; Rommelspacher H; Sinha P; Wernecke KD; Finckh U; Rettig J; Kox WJ; Spies CD
Description
An account of the resource
BACKGROUND: Alcohol abuse may involve an altered neuroendocrine response that mediates lymphocyte-derived proopiomelanocortin (POMC) production and inflammation. We investigated POMC messenger RNA (mRNA) expression in human lymphocytes ex vivo and their relation to plasma ACTH and immunoreactive beta-endorphin (IR-beta-EP) after intravenous injection of human corticotropin releasing factor (hCRF) in chronic alcoholics (n = 12) and nonalcoholics (n = 12) before surgery. Lipopolysaccharide-stimulated interleukin (IL)-1 receptor antagonist (IL-1 Ra) as a marker for chronic inflammation was determined. METHODS: Chronic alcohol abuse was diagnosed according to DSM-IV criteria and alcohol consumption >60 g/day. A reverse transcription-polymerase chain reaction method with total RNA and subsequent solid phase minisequencing was used to quantify lymphocytic POMC mRNA after intravenous hCRF injection. Plasma ACTH, cortisol, and lipopolysaccharide-stimulated IL-1 Ra of monocytes were measured by enzyme-linked immunosorbent assay, and plasma IR-beta-EP was measured by using radioimmunoassay. RESULTS: Baseline values of POMC mRNA content in lymphocytes and IL-1 Ra of chronic alcoholics were significantly increased compared with nonalcoholics (p < 0.01). Thirty minutes after intravenous hCRF injection, a significant increase of lymphocytic POMC mRNA was measured (p < 0.05) in nonalcoholics, whereas in chronic alcoholics a significant decrease was observed (p < 0.05). CONCLUSIONS: Chronic alcoholic patients had an altered neuroendocrine immune axis before intravenous hCRF administration and were not able to adjust to intravenous CRF injection by increasing lymphocytic POMC mRNA expression.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.ALC.0000095636.44770.55" target="_blank" rel="noreferrer">10.1097/01.ALC.0000095636.44770.55</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adult
Aged
Alcoholism, Clinical And Experimental Research
Alcoholism/blood/metabolism
Backlog
Biomarkers of Pain
Corticotropin-Releasing Hormone/pharmacology
Female
Finckh U
Humans
Journal Article
Kox WJ
Lymphocytes/drug effects/metabolism
Male
Messenger/biosynthesis/genetics
Middle Aged
Muhlbauer E
Nonparametric
Pro-Opiomelanocortin/biosynthesis/genetics
Rettig J
RNA
Rommelspacher H
Rosenberger P
Sinha P
Spies CD
Statistics
Weissmuller T
Wernecke KD
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1136/jnnp.74.4.495" target="_blank" rel="noreferrer">http://doi.org/10.1136/jnnp.74.4.495</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis
Publisher
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Journal Of Neurology, Neurosurgery, And Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; Male; Adult; Middle Aged; Magnetic Resonance Imaging; Phenotype; Biomarkers of Pain; Brain/pathology; Leukocytes; Mononuclear/chemistry; beta-Endorphin/blood/genetics; Multiple Sclerosis/blood/genetics/pathology
Creator
An entity primarily responsible for making the resource
Gironi M; Furlan R; Rovaris M; Comi G; Filippi M; Panerai AE; Sacerdote P
Description
An account of the resource
The possible link between the opioid peptide beta endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of beta endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest beta endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest in patients with the progressive forms. Average beta endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that beta endorphin may have a role in the downregulation of the inflammatory process.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/jnnp.74.4.495" target="_blank" rel="noreferrer">10.1136/jnnp.74.4.495</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adult
Backlog
beta-Endorphin/blood/genetics
Biomarkers of Pain
Brain/pathology
Comi G
Female
Filippi M
Furlan R
Gironi M
Humans
Journal Article
Journal Of Neurology, Neurosurgery, And Psychiatry
Leukocytes
Magnetic Resonance Imaging
Male
Middle Aged
Mononuclear/chemistry
Multiple Sclerosis/blood/genetics/pathology
Panerai AE
Phenotype
Rovaris M
Sacerdote P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1196/annals.1296.001" target="_blank" rel="noreferrer">http://doi.org/10.1196/annals.1296.001</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Hormones and the stressed brain
Publisher
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Annals Of The New York Academy Of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Animals; Biomarkers of Pain; Receptors; Hormones/physiology; Stress/physiopathology; Brain/pathology/physiopathology; Glucocorticoid/physiology; Mineralocorticoid/physiology
Creator
An entity primarily responsible for making the resource
De Kloet ER
Description
An account of the resource
The stress system orchestrates brain and body responses to the environment. Cortisol (in humans) or corticosterone (in rodents) are important mediators of the stress system. Their action-in concert-is crucial for individual differences in coping with other individuals, which in turn depend on genetic- and experience-related factors. The actions exerted by cortisol and corticosterone have an enormous diversity. They include the regulation of rapid molecular aggregations, membrane processes, and gene transcription. In the latter transcriptional regulation, the corticosteroid hormones have two modes of operation. One mode is mediated by high-affinity mineralocorticoid receptors (MRs), which control gene networks underlying stabilization of neuronal activity as determinant for the sensitivity to trigger immediate responses to stress organized by corticotrophin-releasing hormone (CRH)-1 receptor. Whereas disturbance of homeostasis is prevented by MR-mediated processes, its recovery is facilitated via the low-affinity glucocorticoid receptors (GRs) that require stress levels of cortisol. GRs promote in coordination with CRH-2 receptors and the parasympathetic system behavioral adaptation and enhances storage of energy and information in preparation for future events. The balance in the two stress system modes is thought to be essential for cell homeostasis, mental performance, and health. Imbalance induced by genetic modification or stressors changes specific neural signaling pathways underlying cognition and emotion. This yin-yang concept in stress regulation is fundamental for genomic strategies to understand the mechanistic underpinning of corticosteroid-induced stress-related disorders such as severe forms of depression.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1296.001" target="_blank" rel="noreferrer">10.1196/annals.1296.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Animals
Annals Of The New York Academy Of Sciences
Backlog
Biomarkers of Pain
Brain/pathology/physiopathology
De Kloet ER
Glucocorticoid/physiology
Hormones/physiology
Journal Article
Mineralocorticoid/physiology
Receptors
Stress/physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1196/annals.1314.033" target="_blank" rel="noreferrer">http://doi.org/10.1196/annals.1314.033</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity?
Publisher
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Annals Of The New York Academy Of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Female; Humans; Male; Adult; Middle Aged; Social Environment; Predictive Value of Tests; Stress; Biomarkers of Pain; Chromatography; High Pressure Liquid; Kinetics; Circadian Rhythm/physiology; Adrenal Medulla/physiopathology; alpha-Amylase/metabolism; Norepinephrine/metabolism; Psychological/enzymology/physiopathology; Saliva/enzymology; Sympathetic Nervous System/physiopathology
Creator
An entity primarily responsible for making the resource
Rohleder N; Nater UM; Wolf JM; Ehlert U; Kirschbaum C
Description
An account of the resource
Assessment of sympathoadrenal medullary system (SAM) activity is only possible to date via measurement of catecholamines in blood plasma or via electrophysiological methods. Both ways of measurement are restricted to endocrinological or psychophysiological laboratories, as both require either immediate freezing of blood samples or complex recording devices. Efforts have therefore been undertaken to find a method comparable to salivary cortisol measurements, in which noninvasive samples can be taken at any place and stored at room temperature for sufficient time before later analysis in the laboratory. Salivary alpha-amylase (sAA) is a candidate that may prove useful in this context. We show here that sAA activity is increased by acute psychosocial stress (Trier Social Stress Test) and that increases in sAA correlate with increases in norepinephrine. We further report that sAA exhibits a stable circadian pattern that mirrors that of salivary cortisol. In conclusion, the current data show that salivary alpha-amylase may serve as an easy-to-use index for SAM activity. However, some questions remain to be answered; for example, what impact does salivary flow rate exert on stress-induced sAA activity?
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1314.033" target="_blank" rel="noreferrer">10.1196/annals.1314.033</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adrenal Medulla/physiopathology
Adult
alpha-Amylase/metabolism
Annals Of The New York Academy Of Sciences
Backlog
Biomarkers of Pain
Chromatography
Circadian Rhythm/physiology
Ehlert U
Female
High Pressure Liquid
Humans
Journal Article
Kinetics
Kirschbaum C
Male
Middle Aged
Nater UM
Norepinephrine/metabolism
Predictive Value of Tests
Psychological/enzymology/physiopathology
Rohleder N
Saliva/enzymology
Social Environment
Stress
Sympathetic Nervous System/physiopathology
Wolf JM
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1210/en.2003-1287" target="_blank" rel="noreferrer">http://doi.org/10.1210/en.2003-1287</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain
Publisher
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Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Male; Animals; Rats; Biomarkers of Pain; Microscopy; Immunohistochemistry; Wistar; beta-Endorphin/biosynthesis; Carboxypeptidase H/metabolism; Extremities; Immunoelectron; Inflammation/immunology/metabolism; Leukocytes/drug effects/metabolism/ultrastructure; Norepinephrine/pharmacology; Pain/immunology/metabolism; Pro-Opiomelanocortin/metabolism; Proprotein Convertase 1/metabolism; Proprotein Convertase 2/metabolism; Secretory Vesicles/metabolism/ultrastructure; Sympathomimetics/pharmacology
Creator
An entity primarily responsible for making the resource
Mousa SA; Shakibaei M; Sitte N; Schafer M; Stein C
Description
An account of the resource
The opioid peptide beta-endorphin (END) as well as mRNA for its precursor proopiomelanocortin (POMC) are found not only in the pituitary gland, but also within various types of immune cells infiltrating inflamed sc tissue. During stressful stimuli END is released and interacts with peripheral opioid receptors to inhibit pain. However, the subcellular pathways of POMC processing and END release have not yet been delineated in inflammatory cells. The aim of the present study was to examine the presence of POMC, carboxypeptidase E, the prohormone convertases 1 (PC1), and 2 (PC2), PC2-binding protein 7B2, and the release of END from inflammatory cells in rats. Using immunohistochemistry we detected END and POMC alone or colocalized with PC1, PC2, carboxypeptidase E, and 7B2 in macrophages/monocytes, granulocytes, and lymphocytes of the blood and within inflamed sc paw tissue. Immunoelectron microscopy revealed that END is localized within secretory granules packed in membranous structures in macrophages, monocytes, granulocytes, and lymphocytes. Finally, END is released by noradrenaline from immune cells in vitro. Taken together, our results indicate that immune cells express the entire machinery required for POMC processing into functionally active peptides such as END and are able to release these peptides from secretory granules.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/en.2003-1287" target="_blank" rel="noreferrer">10.1210/en.2003-1287</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Animals
Backlog
beta-Endorphin/biosynthesis
Biomarkers of Pain
Carboxypeptidase H/metabolism
Endocrinology
Extremities
Immunoelectron
Immunohistochemistry
Inflammation/immunology/metabolism
Journal Article
Leukocytes/drug effects/metabolism/ultrastructure
Male
Microscopy
Mousa SA
Norepinephrine/pharmacology
Pain/immunology/metabolism
Pro-Opiomelanocortin/metabolism
Proprotein Convertase 1/metabolism
Proprotein Convertase 2/metabolism
Rats
Schafer M
Secretory Vesicles/metabolism/ultrastructure
Shakibaei M
Sitte N
Stein C
Sympathomimetics/pharmacology
Wistar