Browse Items · Pediatric Palliative Care Library

Analysis of proopiomelanocortin (POMC) messenger ribonucleic acid and POMC-derived peptides in human peripheral blood mononuclear cells: no evidence for a lymphocyte-derived POMC system

A number of recent studies suggest that cells of the immune system, e.g. peripheral blood mononuclear cells (PBMC), can synthesize and process POMC and secrete POMC-derived peptides, such as ACTH and endorphins, upon immune and hormonal challenges.…

Beta-endorphin levels of children in acute stress

In this study aiming to clarify the relationships between beta-endorphin and glucose levels, beta-endorphin levels were determined in children in acute stress. The study was carried out on 32 critically ill children between 5 days and 12 years…

Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction

Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of…

Endogenous opioids in wound-site neutrophils of sternotomy patients

Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception

Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid…

Hormonal response to surgical stress in schoolchildren

PURPOSE: To determine hormone concentrations (ACTH, cortisol, beta-endorphin) in children before and after surgery, to assess the correlation between any hormonal changes and to study the influence exercised on them by the severity of surgical stress…

Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats

Localized inflammation of a rat's hindpaw elicits an accumulation of beta-endorphin-(END) containing immune cells. We investigated the production, release, and antinociceptive effects of lymphocyte-derived END in relation to cell trafficking. In…

Leukocytes in the regulation of pain and analgesia

When tissue is destroyed or invaded by leukocytes in inflammation, numerous mediators are delivered by the circulation and/or liberated from resident and immigrated cells at the site. Proalgesic mediators include proinflammatory cytokines,…

Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain

We have previously shown that beta-endorphin (END) is contained and released from memory-type T-cells within inflamed tissue and that it is capable to control pain (J Clin Invest 100(1) (1997) 142). Methionine-enkephalin (MET) and Dynorphin-A (DYN)…

Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain

BACKGROUND: Inflammatory pain can be effectively controlled by an interaction of opioid receptors on peripheral sensory nerve terminals with opioid peptides released from immune cells upon stressful stimulation. To define the source of opioid peptide…

Pain reactivity and plasma beta-endorphin in children and adolescents with autistic disorder

BACKGROUND: Reports of reduced pain sensitivity in autism have prompted opioid theories of autism and have practical care ramifications. Our objective was to examine behavioral and physiological pain responses, plasma beta-endorphin levels and their…

Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis

This study investigated the involvement of endogenous opioid peptides in mediating cold water swim (CWS) stress-induced antinociception (SIA) in rats with unilateral hind paw inflammation induced by Freund's complete adjuvant (FCA). Following 0.5, 1…

Physiology of beta-endorphins. A close-up view and a review of the literature

When an endogenous morphine, beta-endorphin was discovered ten years ago, the fact that this morphine is present in the brain and many other tissues suggested to neurobiologists that these peptide opiates play a role which goes beyond that of a…

Tags: 1993, Backlog, Behavior/physiology, Bergal S, beta-Endorphin/physiology, Biomarkers of Pain, Biomarkers Reference List, Biomedicine & Pharmacotherapy, Dalayeun JF, Humans, Ion Channels/physiology, Journal Article, Neurotransmitter Agents, Nores JM, Pain/physiopathology

Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic

A prospective observational study was performed to evaluate whether the plasma concentration of heat shock protein 72 (HSP72) or β-endorphin is related to clinical signs, blood chemistry, or severity of pain of colic. Seventy-seven horses with colic…

Tags: 2010, Backlog, Biomarkers of Pain, Biomarkers Reference List, Journal Article, Koho NM, Korolainen RV, Leppaluoto J, Mykkanen AK, Niinisto KE, Poso AR, Raekallio MR, Ruohoniemi MO, The Veterinary Journal

Proopiomelanocortin and the immune-neuroendocrine connection

This presentation will cover the history, recent developments in, and implications of the ability of both the immune and neuroendocrine systems to produce POMC. The discovery of POMC in immune cells was one of the events that heralded a molecular…

Tags: 1999, Amino Acid Sequence, Animals, Annals Of The New York Academy Of Sciences, Backlog, Base Sequence, Biomarkers of Pain, Biomarkers Reference List, Blalock JE, Humans, Immune System/physiology, Interleukin-1/physiology, Journal Article, Molecular Sequence Data, Neuroimmunomodulation/physiology, Neurosecretory Systems/physiology, Pro-Opiomelanocortin/genetics/physiology

Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma

PURPOSE: To determine the levels of beta-endorphin and cortisol in children with multiple injuries and to determine whether there is any difference between and compare the severity of trauma and beta-endorphin and cortisol release as calculated using…

The Faces Pain Scale-Revised: toward a common metric in pediatric pain measurement

The Faces Pain Scale (FPS; Bieri et al., Pain 41 (1990) 139) is a self-report measure used to assess the intensity of children's pain. Three studies were carried out to revise the original scale and validate the adapted version. In the first phase,…

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