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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
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URL Address
<a href="http://doi.org/10.1002/ajmg.a.31623" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajmg.a.31623</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Behavioral problems in relation to intelligence in children with 22q11.2 deletion syndrome: a matched control study
Publisher
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American Journal of Medical Genetics Part A
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
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Male; Case-Control Studies; Child; Humans; Child Behavior Disorders/psychology; Female; Reproducibility of Results; Syndrome; Psychometrics/methods; Chromosome Deletion; Chromosomes Human Pair 22; Intelligence; Abnormalities Multiple/genetics/pathology/psychology; Craniofacial Abnormalities/psychology; behavioral problems; 22q11.2 deletion syndrome; trajectory; characteristics
Creator
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Jansen P W; Duijff S N; Beemer F A; Vorstman J A; Klaassen P W; Morcus M E; Heineman-de B J A
Description
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The 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with palatal abnormalities, cardiac defects, a characteristic facial appearance, learning difficulties, and delays in speech and language development. Various behavioral disorders and psychiatric illnesses have also been reported. There is much debate as to whether the behavioral problems are caused by factors such as medical discomfort, facial abnormalities or a lower intelligence, or whether they are independently related to the genetic abnormality ("behavioral phenotype"). We examined the relationship between intelligence level and behavioral problems. A group of 69 children with 22q11DS was compared with 69 children with craniofacial anomalies (CFA) using the child behavior checklist (CBCL). The matches between individual children were based on their total IQ scores. Use of the CBCL norm scores covered the corrections for age and sex. The group of 22q11DS children showed significantly more behavioral problems than the CFA group: this was especially apparent on the CBCL subscales "withdrawn," "anxious/depressed," "delinquent behavior," "aggressive behavior," "somatic complaints," and "social problems." We found no correlation between IQ score and behavioral problems in the 22q11DS group, which was remarkable because, comparable with the general population, intellectual disabilities were a predictor of behavioral problems in the CFA group. 22q11DS children with relatively higher IQs showed more problems of an internalizing than an externalizing nature, whereas the 22q11DS children with lower IQs showed various behavioral problems. The absence of a statistically significant correlation between intelligence and behavior problems in the group of 22q11DS children is tentative evidence for a 22q11DS behavioral phenotype.
Identifier
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<a href="http://doi.org/10.1002/ajmg.a.31623" target="_blank" rel="noreferrer noopener">10.1002/ajmg.a.31623</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
22q11.2 Deletion Syndrome
Abnormalities Multiple/genetics/pathology/psychology
American Journal of Medical Genetics Part A
Beemer F A
behavioral problems
Case-Control Studies
characteristics
Child
Child Behavior Disorders/psychology
Chromosome Deletion
Chromosomes Human Pair 22
Craniofacial Abnormalities/psychology
Duijff S N
Female
Heineman-de B J A
Humans
Intelligence
Jansen P W
Klaassen P W
Male
Morcus M E
Psychometrics/methods
Reproducibility of Results
Syndrome
Trajectory
Vorstman J A
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ridd.2013.06.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ridd.2013.06.001</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Cognitive and behavioral trajectories in 22q11DS from childhood into adolescence: A prospective 6-year follow-up study
Publisher
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Research in Developmental Disabilities
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
Subject
The topic of the resource
behavioral problems; 22q11.2 deletion syndrome; trajectory; characteristics; internalizing behaviors
Creator
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Duijff S N; Klaassen P W J; de Veye H; Beemer F A; Sinnema G; Vorstman J A S
Description
An account of the resource
Patients with 22q11DS are at risk of behavioral problems and cognitive impairment. Recent studies suggest a possible intellectual decline in 22q11DS children. To date it is unknown if cognitive development is related to the behavioral problems in 22q11DS. We studied 53 children with 22q11DS who underwent cognitive and behavioral assessments at 9.5 years (T1) and 15.3 years (T2). In about one third, IQ data obtained at 7.5 years (T0) were also available. Results showed that internalizing behaviors intensified while externalizing behaviors decreased. Simultaneously, in about a third a significant decline in IQ was found, which, surprisingly, was unrelated to the behavioral changes. It can be concluded that children with 22q11DS follow a unique developmental trajectory. Cognitive deterioration is severe in some but does not appear to predict behavioral problems in early adolescence. (c) 2013 Elsevier Ltd. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/j.ridd.2013.06.001" target="_blank" rel="noreferrer noopener">10.1016/j.ridd.2013.06.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
22q11.2 Deletion Syndrome
Beemer F A
behavioral problems
characteristics
de Veye H
Duijff S N
internalizing behaviors
Klaassen P W J
Research in Developmental Disabilities
Sinnema G
Trajectory
Vorstman J A S