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Text
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URL Address
<a href="http://doi.org/10.1016/0196-9781(91)90219-f" target="_blank" rel="noreferrer">http://doi.org/10.1016/0196-9781(91)90219-f</a>
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Title
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Age-related changes of beta-endorphin and cholecystokinin in human and rat mononuclear cells
Publisher
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Peptides
Date
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1991
Subject
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Humans; Male; Adult; Aged; Middle Aged; Animals; Rats; 80 and over; beta-Endorphin/blood; Lymphocyte Activation; Aging/blood/immunology; Cholecystokinin/blood; In Vitro; Interleukin-2/biosynthesis; Leukocytes; Mononuclear/immunology/metabolism
Creator
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Sacerdote P; Breda M; Barcellini W; Meroni PL; Panerai AE
Description
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Beta-endorphin (BE) and cholecystokinin (CCK) were measured in fresh PBMC isolated from human subjects and rats. The BE and CCK PBMC contents increased significantly with age both in human and rat models. Moreover, polyclonal stimulation induced a significant decrease of BE but not CCK contents in mononuclear cells from human aged subjects. The time course of changes in BE and CCK concentrations observed in fresh and cultured cells from subjects of different ages did not directly correlate to the time course of age-associated impairment of lectin-induced lymphocyte proliferative response and interleukin-2 synthesis. In fact, the lymphocyte functional defects were significantly observed only in the 71-99 year age group, whereas the neuropeptide changes were already evident in the 31-50 age group. Since BE has been shown to participate in the modulation of the immune system, the age-related modifications of PBMC BE could play a role in the immunodepression observed during aging.
1991
Identifier
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<a href="http://doi.org/10.1016/0196-9781(91)90219-f" target="_blank" rel="noreferrer">10.1016/0196-9781(91)90219-f</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1991
80 And Over
Adult
Aged
Aging/blood/immunology
Animals
Backlog
Barcellini W
beta-Endorphin/blood
Breda M
Cholecystokinin/blood
Humans
In Vitro
Interleukin-2/biosynthesis
Journal Article
Leukocytes
Lymphocyte Activation
Male
Meroni PL
Middle Aged
Mononuclear/immunology/metabolism
Panerai AE
Peptides
Rats
Sacerdote P