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40
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ptj/68.5.664" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ptj/68.5.664</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Effect of hand splints on stereotypic hand behavior of three girls with Rett syndrome
Publisher
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Physical Therapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
Subject
The topic of the resource
Child; Humans; Adolescent; Female; Syndrome; Splints; Stereotyped Behavior; Autistic Disorder; Hand; Intellectual Disability; Neuromuscular Diseases/rehabilitation; tone and motor problems; Rett syndrome; physical intervention; Thumb abduction splints; stereotypic hand behavior; finger-feeding skills; hand splints
Creator
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Naganuma G M; Billingsley F F
Description
An account of the resource
The purpose of this multiple baseline study was to examine the effect of bilateral hand splints on the persistent stereotypic hand movements of three adolescent girls with Rett syndrome. Among the most characteristic features of Rett syndrome are stereotypic hand-writing and hand-biting behavior and loss of previously acquired functional hand skills. The hand splints used in this study consisted of cuffs encircling the palm that positioned the subjects' thumbs in abduction. Duration percentages of subjects' stereotypic hand behavior and functional hand use were calculated from five-minute videotaped segments recorded during a finger-feeding condition and a free-time condition. All three subjects demonstrated a decrease in the amount of time spent in stereotypic hand behavior after application of hand splints, and one subject showed an increase in finger-feeding skills while wearing hand splints. Limitations of the study are discussed, and suggestions for clinical application and future research are offered.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ptj/68.5.664" target="_blank" rel="noreferrer noopener">10.1093/ptj/68.5.664</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Adolescent
Autistic disorder
Billingsley F F
Child
Female
finger-feeding skills
Hand
hand splints
Humans
Intellectual Disability
Naganuma G M
Neuromuscular Diseases/rehabilitation
physical intervention
Physical Therapy
Rett syndrome
splints
Stereotyped Behavior
stereotypic hand behavior
Syndrome
Thumb abduction splints
tone and motor problems
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1089/cap.1990.1.237" target="_blank" rel="noreferrer">http://doi.org/10.1089/cap.1990.1.237</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The opiate hypothesis in autism and self-injury
Publisher
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Journal Of Child And Adolescent Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
Subject
The topic of the resource
Pain Measurement; Analgesics; Pain; Pain Threshold; Naloxone; Naltrexone; Autistic disorder; Self-Injurious behavior; Opioid; Autism; Self Mutiliation
Creator
An entity primarily responsible for making the resource
Sandman CA
Description
An account of the resource
The opiate hypothesis maintains that patients engage in self-injurious behavior (SIB) either because they are partially analgesic (pathologically altered pain threshold) or because SIB supplies a "fix" for an addicted endogenous opiate system. The finding that opiate antogonists attenuate SIB is the strongest evidence for the opiate hypothesis. Most of the patients who had been administered opiate receptor antagonists for treatment of self-injurious behavior also had autistic disorder. Initial studies with naloxone, an injectable opiate blocker, reported positive effects in 8 (with robust effects in 6) of the 10 patients treated. Positive results were reported in studies with orally administered naltrexone in 38 of 45 autistic patients, including 24 of those 28 with SIB. Generally, the effective dose range for naltrexone is 0.5-1.5 mg/kg, but patients with high-frequency SIB typically responded best to the higher doses. Although the findings suggest a role of opiates in SIB, the database is very small and the studies vary widely in dimensions of dose, duration and method of observation, experimental controls, duration of treatment, and the age, gender, and diagnosis of patients treated. At this time, opiate blockers appear to be the only treatment option for some SIB patients who fail to respond to other treatments. It is unclear whether these treatments would help autistic patients who do not exhibit SIB or whether they would help nonautistic patients who demonstrate SIB, including individuals with Lesch-Nyhan disease, phenylketonuria, border-line personality, or major depression.
1990
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/cap.1990.1.237" target="_blank" rel="noreferrer">10.1089/cap.1990.1.237</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1990
Analgesics
Autism
Autistic disorder
Backlog
Journal Article
Journal Of Child And Adolescent Psychopharmacology
Naloxone
Naltrexone
Opioid
Pain
Pain Measurement
Pain Threshold
Sandman CA
Self Mutiliation
Self-Injurious behavior
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/(sici)1098-2779(1999)5:4%3C314::aid-mrdd9%3E3.0.co" target="_blank" rel="noreferrer">http://doi.org/10.1002/(sici)1098-2779(1999)5:4%3C314::aid-mrdd9%3E3.0.co</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Proopiomelanocortin (POMC) disregulation and response to opiate blockers
Publisher
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Mental Retardation And Developmental Disabilities Research Reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Adult; Naltrexone; Autistic disorder; Pro-Opiomelanocortin; Self-Injurious behavior
Creator
An entity primarily responsible for making the resource
Sandman CA; Spence MA; Smith M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1098-2779(1999)5:4%3C314::aid-mrdd9%3E3.0.co" target="_blank" rel="noreferrer">10.1002/(sici)1098-2779(1999)5:4%3C314::aid-mrdd9%3E3.0.co</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
Autism is a collection of disorders or subtypes with distinctive or prominent phenotypes and genotypes. The study of adults with autism offers a unique opportunity to examine its phenotypic diversity. Recent evidence has identified disturbances in specific neurochemical systems that are associated with primary autistic symptoms. Establishing biological markers, such as specific neurochemical disturbances, not only confers greater precision in phenotyping individuals but also provides the basis for rational intervention. Our initial studies in adult individuals exhibiting self-injurious behavior (SIB) generated evidence that the proopiomelanocortin disregulated in subgroups of autistic patients. These findings, corroborated in at least 15 other laboratories, indicated that treatment with an opiate blocker, naltrexone (NTX), reduced SIB in 30-70% of individuals observed. However, the effects of NTX on SIB were not simple. We and others have found that concentration of plasma POMC fragments, specifically opioid fragments, contributed to the symptoms of autism and to the response to treatment. Uncoupling of the release of POMC products predicted the efficacy of NTX treatment on the expression of SIB. Uncoupling of POMC fragments among autistic and SIB patients suggested a basic, underlying defect, perhaps in the POMC gene. The findings of a maternal influence on the C-terminal BE fragment among individuals with autism (Leboyer et al. [1999] Soc Biol Psychiatry 45:158-163) and our preliminary findings, reported here, of a mutation in the opioid region of the POMC gene in an autistic individual were consistent with the prospect that a subgroup of patients will be identified who share a POMC genetic defect.
1999
Adult
Autistic disorder
Backlog
Journal Article
Mental Retardation And Developmental Disabilities Research Reviews
Naltrexone
Pro-Opiomelanocortin
Sandman CA
Self-Injurious behavior
Smith M
Spence MA