1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/nejmoa013171" target="_blank" rel="noreferrer">http://doi.org/10.1056/nejmoa013171</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Risperidone in children with autism and serious behavioral problems
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Adult; adolescent; Antipsychotic Agents/adverse effects; Autistic Disorder/drug therapy; Risperidone/adverse effects; Hyperprolactinemia/chemically induced; Hypogonadism/chemically induced; Osteoporosis/chemically induced
Creator
An entity primarily responsible for making the resource
Valiquette G
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/nejmoa013171" target="_blank" rel="noreferrer">10.1056/nejmoa013171</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Adolescent
Adult
Antipsychotic Agents/adverse effects
Autistic Disorder/drug therapy
Backlog
Humans
Hyperprolactinemia/chemically induced
Hypogonadism/chemically induced
Journal Article
Osteoporosis/chemically induced
Risperidone/adverse effects
The New England Journal Of Medicine
Valiquette G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1542/peds.2003-0264-F" target="_blank" rel="noreferrer">http://doi.org/10.1542/peds.2003-0264-F</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Humans; Male; Treatment Outcome; Double-Blind Method; Preschool; Child Development Disorders; Autistic Disorder/drug therapy; Dopamine Antagonists/therapeutic use; Serotonin Antagonists/therapeutic use; Aggression/drug effects; Antipsychotic Agents/adverse effects/pharmacology/therapeutic use; Irritable Mood/drug effects; Pervasive/drug therapy; Risperidone/adverse effects/pharmacology/therapeutic use
Creator
An entity primarily responsible for making the resource
Shea S; Turgay A; Carroll A; Schulz M; Orlik H; Smith I; Dunbar F
Description
An account of the resource
OBJECTIVE: To investigate the efficacy and safety of risperidone for the treatment of disruptive behavioral symptoms in children with autism and other pervasive developmental disorders (PDD). METHODS: In this 8-week, randomized, double-blind, placebo-controlled trial, risperidone/placebo solution (0.01-0.06 mg/kg/day) was administered to 79 children who were aged 5 to 12 years and had PDD. Behavioral symptoms were assessed using the Aberrant Behavior Checklist (ABC), Nisonger Child Behavior Rating Form, and Clinical Global Impression-Change. Safety assessments included vital signs, electrocardiogram, extrapyramidal symptoms, adverse events, and laboratory tests. RESULTS: Subjects who were taking risperidone (mean dosage: 0.04 mg/kg/day; 1.17 mg/day) experienced a significantly greater mean decrease on the irritability subscale of the ABC (primary endpoint) compared with those who were taking placebo. By study endpoint, risperidone-treated subjects exhibited a 64% improvement over baseline in the irritability score almost double that of placebo-treated subjects (31%). Risperidone-treated subjects also exhibited significantly greater decreases on the other 4 subscales of the ABC; on the conduct problem, insecure/anxious, hyperactive, and overly sensitive subscales of the Nisonger Child Behavior Rating Form (parent version); and on the Visual Analog Scale of the most troublesome symptom. More risperidone-treated subjects (87%) showed global improvement in their condition compared with the placebo group (40%). Somnolence, the most frequently reported adverse event, was noted in 72.5% versus 7.7% of subjects (risperidone vs placebo) and seemed manageable with dose/dose-schedule modification. Risperidone-treated subjects experienced statistically significantly greater increases in weight (2.7 vs 1.0 kg), pulse rate, and systolic blood pressure. Extrapyramidal symptoms scores were comparable between groups. CONCLUSIONS: Risperidone was well tolerated and efficacious in treating behavioral symptoms associated with PDD in children.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1542/peds.2003-0264-F" target="_blank" rel="noreferrer">10.1542/peds.2003-0264-F</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Aggression/drug effects
Antipsychotic Agents/adverse effects/pharmacology/therapeutic use
Autistic Disorder/drug therapy
Backlog
Carroll A
Child
Child Development Disorders
Dopamine Antagonists/therapeutic use
Double-Blind Method
Dunbar F
Female
Humans
Irritable Mood/drug effects
Journal Article
Male
Orlik H
Pediatrics
Pervasive/drug therapy
Preschool
Risperidone/adverse effects/pharmacology/therapeutic use
Schulz M
Serotonin Antagonists/therapeutic use
Shea S
Smith I
Treatment Outcome
Turgay A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/nejmoa013171" target="_blank" rel="noreferrer">http://doi.org/10.1056/nejmoa013171</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Risperidone in children with autism and serious behavioral problems
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Humans; Male; Antipsychotic Agents/adverse effects; Autistic Disorder/drug therapy; Bipolar Disorder/drug therapy; Priapism/chemically induced; Psychotic Disorders/drug therapy; Risperidone/adverse effects
Creator
An entity primarily responsible for making the resource
Munarriz R; Bennett L; Goldstein I
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/nejmoa013171" target="_blank" rel="noreferrer">10.1056/nejmoa013171</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Antipsychotic Agents/adverse effects
Autistic Disorder/drug therapy
Backlog
Bennett L
Bipolar Disorder/drug therapy
Child
Goldstein I
Humans
Journal Article
Male
Munarriz R
Priapism/chemically induced
Psychotic Disorders/drug therapy
Risperidone/adverse effects
The New England Journal Of Medicine