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Text
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<a href="http://doi.org/10.1046/j.1460-9592.1999.00384.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1460-9592.1999.00384.x</a>
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Title
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Efficacy and complications of morphine infusions in postoperative paediatric patients
Publisher
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Paediatric Anaesthesia
Date
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1999
Subject
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Child; Female; Humans; Male; Pain; Analgesics; Follow-Up Studies; Confidence Intervals; Incidence; Acute Disease; adolescent; Preschool; infant; retrospective studies; Infusions; Intravenous; Opioid/administration & dosage/adverse effects/therapeutic use; Morphine/administration & dosage/adverse effects/therapeutic use; Postoperative/prevention & control; Respiration/drug effects; Akathisia; Analgesia/nursing; Anesthesia Recovery Period; Anoxemia/chemically induced; Arousal/drug effects; Drug-Induced/etiology; Postoperative Nausea and Vomiting/chemically induced; Pruritus/chemically induced; Urinary Retention/chemically induced
Creator
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Esmail Z; Montgomery C; Courtrn C; Hamilton D; Kestle J
Description
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The aim of the study was to evaluate the efficacy and the incidence of clinically significant adverse drug reactions (ADRs) in paediatric patients receiving continuous intravenous morphine infusions for acute postoperative pain. Definitions were established for ADRs and data were collected in an immediately retrospective fashion for a maximum of 72 h in 110 patients >/=5 three months of age (0.3-16.7 years) receiving morphine infusions and admitted to a general ward over a three month convenience sampling period. Inadequate analgesia occurred in 65.5% of patients during the first 24 h of therapy and occurred most frequently in patients with infusion rates of 20 microg.kg-1.h-1 or less. Nausea/vomiting was the most commonly experienced ADR (42.5%). The incidence of respiratory depression was 0% (95% CI=0-3.3%). Other ADRs included: urinary retention (13.5%), pruritus (12.7%), dysphoria (7.3%), hypoxaemia (4.5%), discontinuation of morphine for treatment of an ADR (3.6%), and difficulty in arousal (0.9%). The most common ADRs associated with morphine infusions were inadequate analgesia (in the first 24 h) and nausea/vomiting. There were no cases of respiratory depression. Methods of avoiding initial inadequate analgesia and treating nausea and vomiting associated with morphine infusions are needed.
1999
Identifier
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<a href="http://doi.org/10.1046/j.1460-9592.1999.00384.x" target="_blank" rel="noreferrer">10.1046/j.1460-9592.1999.00384.x</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Acute Disease
Adolescent
Akathisia
Analgesia/nursing
Analgesics
Anesthesia Recovery Period
Anoxemia/chemically induced
Arousal/drug effects
Backlog
Child
Confidence Intervals
Courtrn C
Drug-Induced/etiology
Esmail Z
Female
Follow-up Studies
Hamilton D
Humans
Incidence
Infant
Infusions
Intravenous
Journal Article
Kestle J
Male
Montgomery C
Morphine/administration & dosage/adverse effects/therapeutic use
Opioid/administration & dosage/adverse effects/therapeutic use
Paediatric Anaesthesia
Pain
Postoperative Nausea and Vomiting/chemically induced
Postoperative/prevention & control
Preschool
Pruritus/chemically induced
Respiration/drug effects
Retrospective Studies
Urinary Retention/chemically induced