1 40 1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/0270-3092(80)90014-4" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1016/0270-3092(80)90014-4</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Serotonergic approaches to the modification of behavior in the Lesch-Nyhan syndrome Publisher An entity responsible for making the resource available Applied Research in Mental Retardation Date A point or period of time associated with an event in the lifecycle of the resource 1980 Subject The topic of the resource behavioral problems; Lesch-Nyhan syndrome; pharmacologic intervention; 5-hydroxy-tryptophan; self-injurious behavior Creator An entity primarily responsible for making the resource Nyhan W L; Johnson H G; Kaufman I A; Jones K L Description An account of the resource In a series of patients with the Lesch-Nyhan syndrome a pharmacologic attempt was made to alter the balance of biogenic amines in the central nervous system by increasing the level of serotin. Patients were treated with 5-hydroxytryptophan in combination with a peripheral decarboxylase inhibitor carbidopa and with imipramine. Most patients had a striking alteration in self-mutilative behavior. However, within 1–3 months each became tolerant and this pharmacologic effect could not be produced again even a year later. These observations suggest that the characteristic behavior of the patient with the Lesch-Nyhan syndrome is related to neurotransmitter balance, and that there may be ways to modify it. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/0270-3092(80)90014-4" target="_blank" rel="noreferrer noopener">10.1016/0270-3092(80)90014-4</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 1980 5-hydroxy-tryptophan Applied Research in Mental Retardation behavioral problems Johnson H G Jones K L Kaufman I A Lesch-Nyhan syndrome Nyhan W L pharmacologic intervention Self-Injurious behavior