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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1042/bse0390105" target="_blank" rel="noreferrer">http://doi.org/10.1042/bse0390105</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The final step in programmed cell death: phagocytes carry apoptotic cells to the grave.
Publisher
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Essays In Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Animals; Models; Receptors; Signal Transduction; Molecular; Inflammation/metabolism; Apoptosis; Phagocytosis; Biological; Caenorhabditis elegans/genetics; Cell Surface/me [Metabolism]; Drosophila melanogaster/genetics; Evolution; Mice/genetics; Phagocytes/physiology
Creator
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deCathelineau AM; Henson PM
Description
An account of the resource
As cells undergo apoptosis, they are recognized and removed from the body by phagocytes. This oft-overlooked yet critical final step in the cell-death programme protects tissues from exposure to the toxic contents of dying cells and also serves to prevent further tissue damage by stimulating production of anti-inflammatory cytokines and chemokines. The clearance of apoptotic-cell corpses occurs throughout the lifespan of multicellular organisms and is important for normal development during embryogenesis, the maintenance of normal tissue integrity and function, and the resolution of inflammation. Many of the signal-transduction molecules implicated in the phagocytosis of apoptotic cells appear to have a high degree of evolutionary conservation, and therefore the engulfment of apoptotic cells is likely to represent one of the most primitive forms of phagocytosis. With the realization that the signals that govern apoptotic-cell removal also serve to attenuate inflammation and the immune response, as well as initiate signals for tissue repair and remodelling in response to cell death, the study of apoptotic cell clearance is a field experiencing a dynamic increase in interest and momentum.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1042/bse0390105" target="_blank" rel="noreferrer">10.1042/bse0390105</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Animals
Apoptosis
Backlog
Biological
Caenorhabditis elegans/genetics
Cell Surface/me [Metabolism]
deCathelineau AM
Drosophila melanogaster/genetics
Essays In Biochemistry
Evolution
Henson PM
Inflammation/metabolism
Journal Article
Mice/genetics
Models
Molecular
Phagocytes/physiology
Phagocytosis
Receptors
Signal Transduction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1164/rccm.2205023" target="_blank" rel="noreferrer">http://doi.org/10.1164/rccm.2205023</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Apoptosis as a potential mechanism of muscle cachexia in chronic obstructive pulmonary disease
Publisher
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American Journal Of Respiratory And Critical Care Medicine : An Official Journal Of The American Thoracic Society, Medical Section Of The American Lung Association
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Biopsy; Morbidity; Pulmonary Disease; Apoptosis; Cachexia/etiology/pathology/physiopathology; Cell Nucleus/pathology; Chronic Obstructive/complications; Exercise Tolerance; Inflammation; Mitochondria; Muscle Fibers/pathology; Muscle/pathology; Muscular Atrophy/etiology/pathology/physiopathology; Sarcomeres/pathology
Creator
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Lewis MI
Identifier
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<a href="http://doi.org/10.1164/rccm.2205023" target="_blank" rel="noreferrer">10.1164/rccm.2205023</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
American Journal Of Respiratory And Critical Care Medicine : An Official Journal Of The American Thoracic Society, Medical Section Of The American Lung Association
Apoptosis
Backlog
Biopsy
Cachexia/etiology/pathology/physiopathology
Cell Nucleus/pathology
Chronic Obstructive/complications
Exercise Tolerance
Humans
Inflammation
Journal Article
Lewis MI
Mitochondria
Morbidity
Muscle Fibers/pathology
Muscle/pathology
Muscular Atrophy/etiology/pathology/physiopathology
Pulmonary Disease
Sarcomeres/pathology
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/s11926-003-0085-6" target="_blank" rel="noreferrer">http://doi.org/10.1007/s11926-003-0085-6</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonate mechanism of action
Publisher
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Current Rheumatology Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Clodronate; Apoptosis; Bone Resorption/metabolism; Diphosphonates/chemistry/metabolism/pharmacology; Mevalonic Acid/antagonists & inhibitors; Osteoclasts/drug effects/metabolism/physiology; Osteoporosis/metabolism
Creator
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Reszka AA; Rodan GA
Description
An account of the resource
The nitrogen-containing bisphosphonates (N-BPs), alendronate and risedronate, are the only pharmacologic agents shown to prevent spine and nonvertebral fractures associated with postmenopausal and glucocorticoid-induced osteoporosis. At the tissue level, this is achieved through osteoclast inhibition, which leads to reduced bone turnover, increased bone mass, and improved mineralization. The molecular targets of bisphosphonates (BPs) have recently been identified. This review will discuss the mechanism of action of BPs, focusing on alendronate and risedronate, which are the two agents most widely studied. They act on the cholesterol biosynthesis pathway enzyme, farnesyl diphosphate synthase. By inhibiting this enzyme in the osteoclast, they interfere with geranylgeranylation (attachment of the lipid to regulatory proteins), which causes osteoclast inactivation. This mechanism is responsible for N-BP suppression of osteoclastic bone resorption and reduction of bone turnover, which leads to fracture prevention.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11926-003-0085-6" target="_blank" rel="noreferrer">10.1007/s11926-003-0085-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Apoptosis
Backlog
Bone Resorption/metabolism
Clodronate
Current Rheumatology Reports
Diphosphonates/chemistry/metabolism/pharmacology
Humans
Journal Article
Mevalonic Acid/antagonists & inhibitors
Osteoclasts/drug effects/metabolism/physiology
Osteoporosis/metabolism
Reszka AA
Rodan GA