1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/s0167-5273(02)00239-5" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0167-5273(02)00239-5</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Neurohormonal factors in the development of catabolic/anabolic imbalance and cachexia Publisher An entity responsible for making the resource available International Journal Of Cardiology Date A point or period of time associated with an event in the lifecycle of the resource 2002 Subject The topic of the resource Humans; Animals; Heart Failure; Cachexia/etiology/metabolism; Neurotransmitter Agents/metabolism; Biological Markers/blood; Congestive/complications/metabolism; Cytokines/metabolism; Glucocorticoids/metabolism; Insulin-Like Growth Factor I/metabolism; Renin-Angiotensin System/physiology Creator An entity primarily responsible for making the resource Brink M; Anwar A; Delafontaine P Description An account of the resource Mechanisms that lead to cachexia are still poorly understood. The neurohormonal changes that occur in severe disease states may cause an imbalance between protein synthesis and degradation at the cellular level, followed by muscle wasting. Here, we review actions of angiotensin II, TNF-alpha, corticosteroids, insulin-like growth factor-I (IGF-I), and the IGF binding proteins, factors that may each contribute to the metabolic imbalance. The complex endocrine, autocrine and intracellular interactions between these factors will be described with examples from patient, rat and cell culture studies. Moreover, some of the data supporting that each of these hormones may directly affect cellular protein degradation mechanisms will be reviewed. Knowledge on these regulatory mechanisms will facilitate the development of new pharmaceutical strategies to treat cachexia. 2002 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0167-5273(02)00239-5" target="_blank" rel="noreferrer">10.1016/s0167-5273(02)00239-5</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2002 Animals Anwar A Backlog Biological Markers/blood Brink M Cachexia/etiology/metabolism Congestive/complications/metabolism Cytokines/metabolism Delafontaine P Glucocorticoids/metabolism Heart Failure Humans Insulin-Like Growth Factor I/metabolism International Journal Of Cardiology Journal Article Neurotransmitter Agents/metabolism Renin-Angiotensin System/physiology