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Text
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<a href="http://doi.org/10.1016/0196-9781(95)00030-n" target="_blank" rel="noreferrer">http://doi.org/10.1016/0196-9781(95)00030-n</a>
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Title
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Age-related changes in mitogen-induced beta-endorphin release from human peripheral blood mononuclear cells
Publisher
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Peptides
Date
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1995
Subject
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Humans; Adult; Middle Aged; Biomarkers of Pain; Leukocytes; Aging/blood; beta-Endorphin/metabolism; Calcium-Transporting ATPases/antagonists & inhibitors; Calcium/blood; Concanavalin A/pharmacology; Homeostasis/drug effects; Ionomycin/pharmacology; Mitogens/pharmacology; Mononuclear/cytology/drug effects; Phytohemagglutinins/pharmacology; Terpenes/pharmacology; Thapsigargin
Creator
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Manfredi B; Clementi E; Sacerdote P; Bassetti M; Panerai AE
Description
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beta-Endorphin is an opioid peptide synthesized in the pituitary, hypothalamus, and immunocytes, known to affect immune responses both when added in vitro and when its synthesis is increased in vivo (e.g., during stress). We show here that, similar to its concentrations in peripheral blood mononuclear cells, the release of the opioid peptide from these cells after stimulation with polyclonal mitogens such as PHA or Con-A is also age dependent. Moreover, the effect of both mitogens on Ca2+ homeostasis changes with age. Finally, the ionophore ionomycin and the Ca2+ ATPase blocker thapsigargin induce the same age related effect on beta-endorphin release. For these reasons, we suggest that calcium homeostasis might be important for the differences observed in the release of the opioid from cells obtained from younger ( or = 45 years) volunteers.
1995
Identifier
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<a href="http://doi.org/10.1016/0196-9781(95)00030-n" target="_blank" rel="noreferrer">10.1016/0196-9781(95)00030-n</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1995
Adult
Aging/blood
Backlog
Bassetti M
beta-Endorphin/metabolism
Biomarkers of Pain
Calcium-Transporting ATPases/antagonists & inhibitors
Calcium/blood
Clementi E
Concanavalin A/pharmacology
Homeostasis/drug effects
Humans
Ionomycin/pharmacology
Journal Article
Leukocytes
Manfredi B
Middle Aged
Mitogens/pharmacology
Mononuclear/cytology/drug effects
Panerai AE
Peptides
Phytohemagglutinins/pharmacology
Sacerdote P
Terpenes/pharmacology
Thapsigargin