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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0024-3205(02)02415-3" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0024-3205(02)02415-3</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Cytokine and hormone profiles in mice subjected to handling combined with rectal temperature measurement stress and handling only stress
Publisher
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Life Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Animals; Mice; Stress; beta-Endorphin/blood; Biomarkers of Pain; RNA; Killer Cells; Body Temperature/physiology; Adrenocorticotropic Hormone/blood; Cytokines/blood/metabolism; Handling (Psychology); Hormones/blood/metabolism; Inbred BALB C; Messenger/biosynthesis; Natural/physiology; Psychological/metabolism; Spleen/cytology/metabolism
Creator
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Hale KD; Weigent DA; Gauthier DK; Hiramoto RN; Ghanta VK
Description
An account of the resource
Stress is known to either up or down regulate immunity. In this study, mice were subjected to handling combined with rectal temperature measurement (RTM) stress or handling only stress. We investigated whether there were any significant differences in the effect of handling combined with RTM and handling only on NK cell activity, serum cytokine (IL-1beta, IL-6, and TNF-alpha) and ACTH and beta-endorphin levels, and splenic cytokine (IL-1beta, IL-6, TNF-alpha, IFN-alpha, and IFN-beta) levels. Circulating cytokines and hormones and splenic cytokine mRNA levels were measured in individual mice. NK cell activity was significantly increased in both stress groups when compared to the control group. Handling combined with RTM produced significantly increased serum levels of IL-1beta, IL-6, and beta-endorphin. Serum IL-1beta, ACTH, and beta-endorphin were elevated significantly in the handling only group. Splenic TNFalpha mRNA in both of the stress groups and IL-6 mRNA in handling only group decreased significantly. Our observations are supported by existing literature demonstrating that various stressors have differential effects on immune functions and the neuroendocrine hormones and cytokines, which regulate them.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0024-3205(02)02415-3" target="_blank" rel="noreferrer">10.1016/s0024-3205(02)02415-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adrenocorticotropic Hormone/blood
Animals
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Body Temperature/physiology
Cytokines/blood/metabolism
Female
Gauthier DK
Ghanta VK
Hale KD
Handling (Psychology)
Hiramoto RN
Hormones/blood/metabolism
Inbred BALB C
Journal Article
Killer Cells
Life Sciences
Messenger/biosynthesis
Mice
Natural/physiology
Psychological/metabolism
RNA
Spleen/cytology/metabolism
Stress
Weigent DA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1055/s-2001-12195" target="_blank" rel="noreferrer">http://doi.org/10.1055/s-2001-12195</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Hormonal response to surgical stress in schoolchildren
Publisher
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European Journal Of Pediatric Surgery
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Child; Humans; Prospective Studies; Time Factors; adolescent; beta-Endorphin/blood; Biomarkers of Pain; Biomarkers Reference List; Adrenocorticotropic Hormone/blood; Hydrocortisone/blood; Stress/blood
Creator
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Castejon-Casado J; Moreno-Prieto M; Valladares-Mendias JC; Alaminos-Mingorance M; Lopez-Candel E; Ramirez-Navarro A
Description
An account of the resource
PURPOSE: To determine hormone concentrations (ACTH, cortisol, beta-endorphin) in children before and after surgery, to assess the correlation between any hormonal changes and to study the influence exercised on them by the severity of surgical stress and the elective/emergency nature of the surgery. PATIENTS AND METHODS: Prospective cohort of 78 children (age= 10+/-2.6 years, range 6-13 years) undergoing elective or emergency surgery. Preoperative and postoperative (1 and 24 hours postoperation) plasma concentrations of ACTH, cortisol and beta-endorphin were determined in all children. The severity of surgical stress was evaluated as low ( 6) according to the Oxford scale. Student's t-test was used to analyse hormonal changes and the influence of degree of surgical stress and elective/emergency character of the surgery, and Pearson's coefficient for correlations between hormonal values. p < 0.05 was regarded as significant. RESULTS: We observed a significant increase in hormonal concentrations one hour after surgery. ACTH and cortisol values normalised 24 hours after surgery, but beta-endorphin concentrations remained increased. There was a correlation between ACTH and beta-endorphin values both before surgery and one hour after. Operations with high surgical stress significantly increased cortisol concentrations one hour after surgery and beta-endorphin concentrations 24 hours after surgery. Patients selected for emergency surgery showed significantly higher concentrations of cortisol and ACTH both before and after surgery. CONCLUSIONS: Postoperative hormonal response among children of school age is characterised by increases in ACTH, cortisol and beta-endorphin one hour after surgery, and by high concentrations of beta-endorphin 24 hours after surgery. Cortisol is an index of surgical stress. Emergency surgery is associated with significant increases in ACTH and cortisol.
2001
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1055/s-2001-12195" target="_blank" rel="noreferrer">10.1055/s-2001-12195</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
Adolescent
Adrenocorticotropic Hormone/blood
Alaminos-Mingorance M
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Biomarkers Reference List
Castejon-Casado J
Child
European Journal Of Pediatric Surgery
Humans
Hydrocortisone/blood
Journal Article
Lopez-Candel E
Moreno-Prieto M
Prospective Studies
Ramirez-Navarro A
Stress/blood
Time Factors
Valladares-Mendias JC