Outcome of children treated for relapsed acute myeloid leukemia in Central America
adolescent; Child; Female; Humans; Male; retrospective studies; Survival Rate; Time Factors; Leukemia; Preschool; Acute; Central America; Disease-Free Survival; Promyelocytic; Recurrence
BACKGROUND: Relapsed childhood acute myeloid leukemia (AML) outcomes have not been documented in resource-limited settings. We examined survival after relapse for children with AML (non-APML) and acute promyelocytic leukemia (APML) in Central America. PROCEDURE: We retrospectively evaluated outcomes of children with first relapse of AML (non-APML) and APML in Guatemala, Honduras, or El Salvador diagnosed between 1997 and 2011. Predictors of subsequent event-free survival (EFS) and overall survival (OS) were examined. RESULTS: We identified 140 children with relapsed AML (non-APML), and 24 with relapsed APML. Two-year subsequent EFS and OS (±SE) were 7.0 ± 2.5% and 9.1 ± 2.8%, respectively. Worse outcomes were associated with Hispanic or Indigenous heritage, white blood cell count at diagnosis ≥50 × 10(9) /L, and time to relapse <18 months. For those with relapsed APML, subsequent 2-year EFS and OS were 36.7 ± 10.8% and 43.4 ± 12.1%, although few patients survived beyond 3 years. 15.2% of all patients were managed solely with palliative intent following first relapse. CONCLUSIONS: Children with relapsed AML in Central America rarely survive, so palliative strategies should be considered following relapse in this population. However, children with late relapse or with APML may have a prolonged period of remission with second treatment, and consideration of re-treatment may be appropriate.
2014-07
Marjerrison S; Antillon F; Bonilla M; Fu L; Martinez R; Valverde P; Vasquez R; Howard SC; Ribeiro RC; Sung L
Pediatric Blood & Cancer
2014
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1002/pbc.24942" target="_blank" rel="noreferrer">10.1002/pbc.24942</a>
Description and adequacy of parental coping behaviours in childhood leukaemia
PedPal Lit; Acute; Lymphocytic; Adaptation; L1/psychology/therapy Life Change Events Male Middle Aged Nursing Methodology Research Parents/education/psychology Professional-Family Relations Questionnaires Self Concept Sex Factors Social Support; Pediatric HumansLeukemia; Preschool Communication Family Health Fear Female Greece Hospitals; Psychological Adolescent Adult Analysis of VarianceAttitude to Health Child Child
This investigation explored how parents perceived the child's leukaemia and how well coped with it. Forty-one mothers and 30 fathers recruited from the largest Hellenic paediatric hospital were asked to answer closed and open-ended questions and to complete the Coping Health Inventory for Parents [CHIP]. Most of the participants perceived the child's disease as a serious and threatening situation. The strategies aimed at maintaining family strength and an optimistic outlook were ranked as being the most helpful. Using specific criteria, it became evident that, overall, the subjects coped well. Neither gender nor spousal differences were found in the variables examined. Implications for health-related research, theory and practitioners are addressed.
2005
Patistea E
International Journal Of Nursing Studies
2005
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/j.ijnurstu.2004.06.010" target="_blank" rel="noreferrer">10.1016/j.ijnurstu.2004.06.010</a>
A difference in perception of quality of life in chronically ill children was found between parents and pediatricians
Pediatrics; Psychology; quality of life; PedPal Lit; Acute; Lymphocytic; physiopathology; [95% CI 2.00-11.22]); [95% CI 2.88-18.97]; Adolescent Arthritis; and asthma (2.3; juvenile idiopathic arthritis (4.7; Juvenile Rheumatoid/physiopathology/psychology/rehabilitation Asthma/physiopathology/psychology/rehabilitation Child Child; physiology Male Pain; physiopathology Parents; Preschool Chronic Disease/psychology/; rehabilitation Cognition Cross-Sectional Studies Cystic Fibrosis; rehabilitation Emotions Female Health Status Indicators Humans Infant Leukemia; rehabilitation Locomotion; Social Perception Speech/physiology
2005
Janse AJ; Uiterwaal CS; Gemke RJ; Kimpen JL; Sinnema G
Journal Of Clinical Epidemiology
2005
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/j.jclinepi.2004.09.010" target="_blank" rel="noreferrer">10.1016/j.jclinepi.2004.09.010</a>
A framework for integrated pediatric palliative care: being with dying
Child; Female; Humans; Male; Palliative Care; patient care team; decision making; Parents; Cooperative Behavior; Goals; Nurse's Role; Pediatric Nursing; Interprofessional Relations; Conflict (Psychology); Holistic Health; Self Care; Self-Assessment; Benchmarking; Leukemia; Philosophy; Uncertainty; Myeloid; quality of life; PedPal Lit; Models; PEDI Study; Acute; Nursing; Organizational
Recent studies highlight the need for an integrated model for palliative and end-of-life pediatric care. About 55,000 children die each year in the United States and, on any given day, about 8,600 children could benefit from care that acknowledges their limited life expectancy and severity of illness. Two case studies of children illustrate different approaches-one that aggressively applies all possible technologies to maximize chances of survival and another that focuses on the patient's overall quality of life and on healing rather than curing. The cases highlight characteristics of an integrated model of palliative care to address clinical, moral, and ethical uncertainties. This model integrates being with doing, provides for developing attunement and presence as capacities for being with children and their parents, and addresses challenges in the healthcare environment. Strategies for integrating palliative care into pediatric practice include listening, fostering respect for the child and parents across the organization, nurturing collaborative connections, managing uncertainty, tolerating ambiguity, making peace with conflict, and committing to self-care. Every pediatric nurse can play a role in making the vision of palliative care a reality integrated into the fabric of pediatric practice.
2005-10
Rushton CH
Journal Of Pediatric Nursing
2005
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/j.pedn.2005.03.003" target="_blank" rel="noreferrer">10.1016/j.pedn.2005.03.003</a>
Osteoporosis at presentation of childhood ALL: management with pamidronate
Child; Female; Humans; Male; Leukemia; Preschool; Clodronate; Acute; Lymphocytic; Bone Density/drug effects; Diphosphonates/administration & dosage; Fractures; Bone Density Conservation Agents/administration & dosage; L1/complications/radiography/therapy; Osteoporosis/drug therapy/etiology/radiography; Spinal Fractures/drug therapy/etiology/radiography; Spontaneous/drug therapy/etiology/radiography
Vertebral fractures at diagnosis of childhood acute lymphoblastic leukemia (ALL) are an uncommon but recognized problem. Clinical issues associated with pathological fractures in these children include pain control and the potential for further treatment-associated fractures and long-term bony morbidity. The authors report the successful use of pamidronate in two children who presented with vertebral compression fractures at diagnosis of ALL. Both patients had pain and low bone mineral density at baseline. In addition to standard chemotherapy, pamidronate (1 mg/kg, IV) was given bimonthly. Initial rapid symptom relief and gradual improvement of bone mineral density was demonstrated in both patients.
2005
Goldbloom EB; Cummings EA; Yhap M
Pediatric Hematology And Oncology
2005
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1080/08880010500198285" target="_blank" rel="noreferrer">10.1080/08880010500198285</a>
Clinical application of family management styles to families of children with cancer
PedPal Lit; Acute; Lymphocytic; Adaptation; L1/nursing/psychology Male Models; Psychological Adolescent Adult Child Female Hodgkin Disease/nursing/psychology Humans Leukemia; Psychological Neoplasms/nursing/psychology Nuclear Family/psychology Nursing Assessment/methods
The potential clinical application of family management styles for working with families who have children with cancer is discussed. Case studies are used to illustrate the usefulness and clinical application of the model.
2006
Ogle SK
Journal Of Pediatric Oncology Nursing
2006
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1177/1043454205283586" target="_blank" rel="noreferrer">10.1177/1043454205283586</a>
Osteopenia in children with acute lymphoblastic leukemia: a pilot study of amelioration with Pamidronate
Child; Female; Humans; Male; Pilot Projects; Leukemia; Drug Administration Schedule; Bone Diseases; adolescent; Preschool; P.H.S.; Research Support; U.S. Gov't; Clodronate; Acute; Anti-Inflammatory Agents/administration & dosage/therapeutic use; Antineoplastic Agents/administration & dosage/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Asparaginase/therapeutic use; Dexamethasone/therapeutic use; Diphosphonates/administration & dosage/therapeutic use; Doxorubicin/therapeutic use; L1/complications/drug therapy; Lymphocytic; Metabolic/drug therapy/etiology
2002
Barr RD; Guo CY; Wiernikowski J; Webber C; Wright M; Atkinson S
Medical & Pediatric Oncology
2002
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1002/mpo.10057" target="_blank" rel="noreferrer">10.1002/mpo.10057</a>
The reactions to research participation questionnaires for children and for parents (RRPQ-C and RRPQ-P)
Child; Female; Humans; Male; Adult; Parents; Pilot Projects; Attitude; Patient Participation; Risk Assessment; Research; Wounds and Injuries; Statistical; Stress Disorders; Acute; Factor Analysis; Traumatic; Surveys and Questionnaires; Patient Selection
Systematic assessment of the effect of clinical research studies on child and parent participants has been limited. Such assessment could provide an empirical basis for the ethical conduct of research, assisting investigators and institutional review boards in balancing the need for sound research with the need to protect study participants. The Reactions to Research Participation Questionnaire for Children (RRPQ-C) and the RRPQ for Parents (RRPQ-P) are brief measures designed to assess child or parent views of clinical research studies. Both measures were piloted and then administered as part of an interview-based study of traumatically injured children and their parents, to assess their psychometric properties and potential usefulness as addenda to future study protocols. The RRPQ-C and RRPQ-P each demonstrated acceptable internal consistency. Exploratory factor analyses provided general support for their conceptual basis. Both were easily administered and well-accepted by respondents. There is evidence that children and adults were willing to answer honestly, even about negative responses. Brief measures such as the RRPQ-C and RRPQ-P may provide a practical and empirically informed method for assessing children's and parents' responses to research participation. Investigators should consider including systematic standardized assessment of participant reactions in child clinical research studies.
2002-10
Kassam-Adams N; Newman E
General Hospital Psychiatry
2002
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Journal Article
<a href="http://doi.org/10.1016/s0163-8343(02)00200-1" target="_blank" rel="noreferrer">10.1016/s0163-8343(02)00200-1</a>
The pain experience of children with leukemia during the first year after diagnosis
U.S. Gov't; PedPal Lit; Acute; Lymphocytic; respectively; Adaptation; 0-100). The most common location of pain was the legs (26.5%) in all seven interviews. Other frequently noted sites were the abdomen (16.6%); 0-4). For the children 8 to 17 years old; ages 4 to 17 years; and back (14.(TRUNCATED); and from their English- and Spanish-speaking parents. Age-appropriate instruments were used to examine the variables of pain intensity; and functional status. RESULTS: All the children reported pain over the course of the year. Pain intensity scores incorporated the full range of possible responses. For the children 4 to 7 years old; and outcomes during the first year after the diagnosis of acute leukemia. METHODS: A longitudinal descriptive approach was used to collect data at seven data points from 95 English- and Spanish-speaking children; and quality; and the associated procedures. For children with leukemia; as well as strategies for managing pain; head/neck (16.6%); L1/complications Longitudinal Studies Male Models; location; management strategies; P.H.S. Treatment Outcome%X BACKGROUND: Children with cancer experience pain related to the disease process; pattern over time; perceived effectiveness of management strategies; Preschool European Continental Ancestry Group/psychology Female Hispanic Americans/psychology Humans Leukemia; Psychological Adolescent African Americans/psychology Age Factors Analysis of Variance Asian Americans/psychologyAttitude to Health California ChildChild Psychology Child; Psychological Nursing Assessment Nursing Methodology Research Pain/etiology/prevention & control/psychology Pain Measurement Questionnaires Research Support; receiving care in one of three southern California hospitals; the highest and lowest mean scores; the pain experienced after diagnosis has received scant attention. OBJECTIVE: To examine the pain experience; the treatment; were 2 and 1.6 (scale; were 50.1 and 39.5 (scale
2004
Van Cleve L; Bossert E; Beecroft P; Adlard K; Alvarez O; Savedra MC
Nursing Research
2004
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1097/00006199-200401000-00001" target="_blank" rel="noreferrer">10.1097/00006199-200401000-00001</a>
Bisphosphonates for treatment of childhood hypercalcemia
Child; Female; Humans; Leukemia; adolescent; Preschool; Clodronate; Diphosphonates/therapeutic use; Acute; Lymphocytic; Calcium/blood; Hypercalcemia/drug therapy/etiology; Immobilization/adverse effects; L1/complications
Most clinicians only have a limited experience in treating childhood hypercalcemia with bisphosphonates. We report our experience in the use of intravenous and oral bisphosphonates in a 5-year-old with hypercalcemia secondary to acute lymphocytic leukemia, a 16-year-old with immobilization hypercalcemia, and a 14-year-old with chronic hypercalcemia of unknown cause. Single infusions of 0.5 mg/kg and 1 mg/kg of intravenous pamidronate were administered over 4 hours. No adverse reactions were observed except for hypocalcemia. A dose between 10 and 20 mg of oral alendronate was successfully used to maintain normocalcemia in the patient with chronic hypercalcemia. In our experience, the administration of bisphosphonates has enabled us to achieve normocalcemia in all cases, and in all cases there were no significant side effects. Long-term potential side effects from their use in children during the active phase of growth remain unknown.
1998
Lteif AN; Zimmerman D
Pediatrics
1998
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Journal Article
<a href="http://doi.org/10.1203/00006450-199804001-00475" target="_blank" rel="noreferrer">10.1203/00006450-199804001-00475</a>