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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
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URL Address
<a href="http://doi.org/10.3164/jcbn.16-52" target="_blank" rel="noreferrer noopener">http://doi.org/10.3164/jcbn.16-52</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Supplementation with carnitine reduces the severity of constipation: A retrospective study of patients with severe motor and intellectual disabilities
Publisher
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Journal of Clinical Biochemistry and Nutrition
Date
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2017
Subject
The topic of the resource
cerebral palsy; enteric feeding; clinical trial; endogenous compound; sex difference; human tissue; intellectual impairment; school child; preschool child; gene expression; medical record review; human; article; child; female; male; controlled study; adult; clinical article; young adult; hospital; middle aged; disease severity; retrospective study; body mass; cholesterol/ec [Endogenous Compound]; infantile spasm; neuronal ceroid lipofuscinosis; clobazam/dt [Drug Therapy]; clonazepam/dt [Drug Therapy]; carnitine; carnitine deficiency/dt [Drug Therapy]; carnitine/dt [Drug Therapy]; constipation; constipation/dt [Drug Therapy]; constipation/pc [Prevention]; diet supplementation; motor dysfunction; 102767-28-2 (levetiracetam); 1069-66-5 (valproic acid); 1309-48-4 (magnesium oxide); 1317-74-4 (magnesium oxide); 14093-02-8 (iron); 14378-32-6 (zinc); 146-22-5 (nitrazepam); 1622-61-3 (clonazepam); 22316-47-8 (clobazam); 298-46-4 (carbamazepine); 461-06-3 (carnitine); 50-06-6 (phenobarbital); 53858-86-9 (iron); 541-15-1 (carnitine); 56-99-5 (carnitine); 57-30-7 (phenobarbital); 57-88-5 (cholesterol); 59-30-3 (folic acid); 6484-89-5 (folic acid); 68291-97-4 (zonisamide); 7439-89-6 (iron); 7440-66-6 (zinc); 7782-49-2 (selenium); 8028-68-0 (phenobarbital); 8047-84-5 (carbamazepine); 84057-84-1 (lamotrigine); 99-66-1 (valproic acid); acute brain disease; albumin; albumin blood level; anticonvulsant therapy; bacterial meningitis; bed rest; brain infarction; carbamazepine/dt [Drug Therapy]; carnitine deficiency; carnitine deficiency/dt [Drug Therapy]; cholesterol blood level; constipation/dt [Drug Therapy]; copper blood level; cupric ion/ec [Endogenous Compound]; enema/dt [Drug Therapy]; epilepsy/dt [Drug Therapy]; folic acid; folic acid blood level; folic acid/ec [Endogenous Compound]; groups by age; iron blood level; iron/ec [Endogenous Compound]; lamotrigine/dt [Drug Therapy]; levetiracetam/dt [Drug Therapy]; magnesium oxide/dt [Drug Therapy]; nitrazepam/dt [Drug Therapy]; Pelizaeus Merzbacher disease; periventricular leukomalacia; phenobarbital/dt [Drug Therapy]; prealbumin; prealbumin/ec [Endogenous Compound]; selenium blood level; selenium/ec [Endogenous Compound]; trace element; tuberous sclerosis; valproic acid; valproic acid/dt [Drug Therapy]; zinc/ec [Endogenous Compound]; zonisamide/dt [Drug Therapy]; constipation; NCL3; Pelizaeus- Merzbacher disease; tuberous sclerosis; West syndrome; pharmacologic intervention; Carnitine
Creator
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Murata S; Inoue K; Aomatsu T; Yoden A; Tamai H
Description
An account of the resource
Carnitine is an essential nutrient for the mitochondrial transport of fatty acids. Carnitine deficiency causes a variety of symptoms in multiple organs. Patients with severe motor and intellectual disabilities often have carnitine deficiency. This study aimed to determine the correlation between constipation and carnitine deficiency in them. Patients with severe motor and intellectual disabilities at our hospital were retrospectively reviewed. The correlation between level of free carnitine and severity of constipation was examined. Constipation and non-constipation groups were compared for age; sex; body mass index; bed rest period; use of anti-epileptic drugs, valproate sodium, or enteral nutrition; and serum levels of albumin, pre-albumin, totalcholesterol, free carnitine, folic acid, and trace elements. Moreover, severity of constipation before and after carnitine supplementation was assessed. Twenty-seven patients were enrolled. Of these, 14 were assigned to the constipation group and 13 to the non-constipation group. The free carnitine level was significantly correlated with severity of constipation (R = 0.7604, p<0.01). Free carnitine was significantly lower in the constipation compared with the non-constipation group (p<0.01). No other significant differences between the groups were found. The severity of constipation was significantly relieved after carnitine supplementation (p<0.001). In conclusion, carnitine supplementation could reduce the severity of constipation. Copyright © 2017 JCBN.
Identifier
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<a href="http://doi.org/10.3164/jcbn.16-52" target="_blank" rel="noreferrer noopener">10.3164/jcbn.16-52</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
102767-28-2 (levetiracetam)
1069-66-5 (valproic acid)
1309-48-4 (magnesium oxide)
1317-74-4 (magnesium oxide)
14093-02-8 (iron)
14378-32-6 (zinc)
146-22-5 (nitrazepam)
1622-61-3 (clonazepam)
2017
22316-47-8 (clobazam)
298-46-4 (carbamazepine)
461-06-3 (carnitine)
50-06-6 (phenobarbital)
53858-86-9 (iron)
541-15-1 (carnitine)
56-99-5 (carnitine)
57-30-7 (phenobarbital)
57-88-5 (cholesterol)
59-30-3 (folic acid)
6484-89-5 (folic acid)
68291-97-4 (zonisamide)
7439-89-6 (iron)
7440-66-6 (zinc)
7782-49-2 (selenium)
8028-68-0 (phenobarbital)
8047-84-5 (carbamazepine)
84057-84-1 (lamotrigine)
99-66-1 (valproic acid)
acute brain disease
Adult
albumin
albumin blood level
anticonvulsant therapy
Aomatsu T
Article
bacterial meningitis
bed rest
body mass
brain infarction
carbamazepine/dt [Drug Therapy]
carnitine
carnitine deficiency
carnitine deficiency/dt [Drug Therapy]
carnitine/dt [Drug Therapy]
Cerebral Palsy
Child
cholesterol blood level
cholesterol/ec [Endogenous Compound]
Clinical Article
Clinical Trial
clobazam/dt [Drug Therapy]
clonazepam/dt [Drug Therapy]
Constipation
constipation/dt [Drug Therapy]
constipation/pc [Prevention]
Controlled Study
copper blood level
cupric ion/ec [Endogenous Compound]
diet supplementation
Disease Severity
Endogenous Compound
enema/dt [Drug Therapy]
enteric feeding
epilepsy/dt [Drug Therapy]
Female
folic acid
folic acid blood level
folic acid/ec [Endogenous Compound]
Gene Expression
groups by age
Hospital
Human
Human Tissue
infantile spasm
Inoue K
Intellectual Impairment
iron blood level
iron/ec [Endogenous Compound]
Journal of Clinical Biochemistry and Nutrition
lamotrigine/dt [Drug Therapy]
levetiracetam/dt [Drug Therapy]
magnesium oxide/dt [Drug Therapy]
Male
Medical Record Review
Middle Aged
motor dysfunction
Murata S
NCL3
neuronal ceroid lipofuscinosis
nitrazepam/dt [Drug Therapy]
Pelizaeus Merzbacher disease
Pelizaeus- Merzbacher disease
periventricular leukomalacia
pharmacologic intervention
phenobarbital/dt [Drug Therapy]
prealbumin
prealbumin/ec [Endogenous Compound]
Preschool Child
Retrospective Study
School Child
selenium blood level
selenium/ec [Endogenous Compound]
sex difference
Tamai H
trace element
Tuberous Sclerosis
valproic acid
valproic acid/dt [Drug Therapy]
West syndrome
Yoden A
Young Adult
zinc/ec [Endogenous Compound]
zonisamide/dt [Drug Therapy]