Enteric nervous system and developmental abnormalities in childhood

Enteric nervous system and developmental abnormalities in childhood

Paran TS; Rolle U; Puri P

Pediatric Surgery International

2006

Child; Humans; Animals; Gastrointestinal Motility/physiology; Neurons/physiology; Chromosome Aberrations; Ganglion Cysts/embryology; Gastrointestinal Tract/innervation; Glial Cell Line-Derived Neurotrophic Factors/physiology; Hirschsprung Disease/physiopathology; Nervous System Malformations/embryology/physiopathology; Neural Crest/embryology; Neurotransmitter Agents/physiology

ENS consists of a complex network of neurons, organised in several plexuses, which interact by means of numerous neurotransmitters. It is capable of modulating the intestinal motility, exocrine and endocrine secretions, microcirculation and immune and inflammatory responses within the gastrointestinal tract, independent of the central nervous system. Though the embryological development of various plexuses are completed by mid-way of gestation, the maturation of neurons and nerve plexuses appear to continue well after birth. Therefore, any histological or functional abnormalities related to the gastrointestinal function must be investigated with the ongoing maturational processes in mind.

2006

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